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Iftakhar-E-Khuda I, Pessia A, Zheng S, et al. Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation. Cell Mol Life Sci. 2021;78(23):7851-7872doi: 10.1007/s00018-021-03977-6.
Iftakhar-E-Khuda, I., Pessia, A., Zheng, S., Kankainen, M., Kontro, M., Karikoski, M., Laurila, J., Gerke, H., Tadayon, S., Hollmén, M., Tang, J., Imhof, B. A., Salmi, M., & Jalkanen, S. (2021). Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation. Cellular and molecular life sciences : CMLS, 78(23), 7851-7872. https://doi.org/10.1007/s00018-021-03977-6
Iftakhar-E-Khuda, Imtiaz, et al. "Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation." Cellular and molecular life sciences : CMLS vol. 78,23 (2021): 7851-7872. doi: https://doi.org/10.1007/s00018-021-03977-6
Iftakhar-E-Khuda I, Pessia A, Zheng S, Kankainen M, Kontro M, Karikoski M, Laurila J, Gerke H, Tadayon S, Hollmén M, Tang J, Imhof BA, Salmi M, Jalkanen S. Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation. Cell Mol Life Sci. 2021 Dec;78(23):7851-7872. doi: 10.1007/s00018-021-03977-6. Epub 2021 Nov 01. PMID: 34719737.
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Cell Mol Life Sci. 2021 Dec;78(23):7851-7872. doi: 10.1007/s00018-021-03977-6. Epub 2021 Nov 01.

Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation.

Cellular and molecular life sciences : CMLS

Imtiaz Iftakhar-E-Khuda, Alberto Pessia, Shuyu Zheng, Matti Kankainen, Mika Kontro, Marika Karikoski, Juha Laurila, Heidi Gerke, Sina Tadayon, Maija Hollmén, Jing Tang, Beat A Imhof, Marko Salmi, Sirpa Jalkanen

Affiliations

  1. Medicity Research Laboratory, University of Turku, 20520, Turku, Finland.
  2. Research Program in Systems Oncology (ONCOSYS), Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  3. Department of Hematology, Helsinki University Hospital, Helsinki, Finland.
  4. Department of Pathology and Immunology, Centre Médical Universitaire (CMU), University of Geneva, Rue Michel-Servet 1, CH-1211, Geneva, Switzerland.
  5. Medicity Research Laboratory, University of Turku, 20520, Turku, Finland. [email protected].

PMID: 34719737 DOI: 10.1007/s00018-021-03977-6

Abstract

Although the development of hematopoietic stem cells (HSC) has been studied in great detail, their heterogeneity and relationships to different cell lineages remain incompletely understood. Moreover, the role of Vascular Adhesion Protein-1 in bone marrow hematopoiesis has remained unknown. Here we show that VAP-1, an adhesin and a primary amine oxidase producing hydrogen peroxide, is expressed on a subset of human HSC and bone marrow vasculature forming a hematogenic niche. Bulk and single-cell RNAseq analyses reveal that VAP-1

© 2021. The Author(s).

Keywords: Amine oxidase; Hematopoiesis; Oxygen radicals; Stem cells; Transplantation

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