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Biermann M, Reya T. Hematopoietic Stem Cells and Regeneration. Cold Spring Harb Perspect Biol. 2021;doi: 10.1101/cshperspect.a040774.
Biermann, M., & Reya, T. (2021). Hematopoietic Stem Cells and Regeneration. Cold Spring Harbor perspectives in biology, . https://doi.org/10.1101/cshperspect.a040774
Biermann, Mitch, and Reya, Tannishtha. "Hematopoietic Stem Cells and Regeneration." Cold Spring Harbor perspectives in biology vol. (2021). doi: https://doi.org/10.1101/cshperspect.a040774
Biermann M, Reya T. Hematopoietic Stem Cells and Regeneration. Cold Spring Harb Perspect Biol. 2021 Nov 08; doi: 10.1101/cshperspect.a040774. Epub 2021 Nov 08. PMID: 34750175.
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Cold Spring Harb Perspect Biol. 2021 Nov 08; doi: 10.1101/cshperspect.a040774. Epub 2021 Nov 08.

Hematopoietic Stem Cells and Regeneration.

Cold Spring Harbor perspectives in biology

Mitch Biermann, Tannishtha Reya

Affiliations

  1. Department of Medicine, University of California San Diego, La Jolla, California 92093.
  2. Department of Pharmacology, University of California San Diego, La Jolla, California 92093.

PMID: 34750175 DOI: 10.1101/cshperspect.a040774

Abstract

Hematopoietic stem cell (HSC) regeneration is the remarkable process by which extremely rare, normally inactive cells of the bone marrow can replace an entire organ if called to do so by injury or harnessed by transplantation. HSC research is arguably the first quantitative single-cell science and the foundation of adult stem cell biology. Bone marrow transplant is the oldest and most refined technique of regenerative medicine. Here we review the intertwined history of the discovery of HSCs and bone marrow transplant, the molecular and cellular mechanisms of HSC self-renewal, and the use of HSCs and their derivatives for cell therapy.

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