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Voglhuber J, Ljubojevic-Holzer S, Abdellatif M, et al. Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics. Front Nutr. 2021;8:758058doi: 10.3389/fnut.2021.758058.
Voglhuber, J., Ljubojevic-Holzer, S., Abdellatif, M., & Sedej, S. (2021). Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics. Frontiers in nutrition, 8758058. https://doi.org/10.3389/fnut.2021.758058
Voglhuber, Julia, et al. "Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics." Frontiers in nutrition vol. 8 (2021): 758058. doi: https://doi.org/10.3389/fnut.2021.758058
Voglhuber J, Ljubojevic-Holzer S, Abdellatif M, Sedej S. Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics. Front Nutr. 2021 Sep 30;8:758058. doi: 10.3389/fnut.2021.758058. eCollection 2021. PMID: 34660673; PMCID: PMC8514725.
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Front Nutr. 2021 Sep 30;8:758058. doi: 10.3389/fnut.2021.758058. eCollection 2021.

Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics.

Frontiers in nutrition

Julia Voglhuber, Senka Ljubojevic-Holzer, Mahmoud Abdellatif, Simon Sedej

Affiliations

  1. Department of Cardiology, Medical University of Graz, Graz, Austria.
  2. BioTechMed Graz, Graz, Austria.
  3. Centre de Recherche des Cordeliers, Equipe labellisée par La Ligue Contre le Cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institute Universitaire de France, Paris, France.
  4. Faculty of Medicine, Institute of Physiology, University of Maribor, Maribor, Slovenia.

PMID: 34660673 PMCID: PMC8514725 DOI: 10.3389/fnut.2021.758058

Abstract

The average human life expectancy continues to rise globally and so does the prevalence and absolute burden of cardiovascular disease. Dietary restriction promotes longevity and improves various cardiovascular risk factors, including hypertension, obesity, diabetes mellitus, and metabolic syndrome. However, low adherence to caloric restriction renders this stringent dietary intervention challenging to adopt as a standard practice for cardiovascular disease prevention. Hence, alternative eating patterns and strategies that recapitulate the salutary benefits of caloric restriction are under intense investigation. Here, we first provide an overview of alternative interventions, including intermittent fasting, alternate-day fasting and the Mediterranean diet, along with their cardiometabolic effects in animal models and humans. We then present emerging pharmacological alternatives, including spermidine, NAD

Copyright © 2021 Voglhuber, Ljubojevic-Holzer, Abdellatif and Sedej.

Keywords: autophagy; caloric restriction; caloric restriction mimetics; cardiovascular risk factors; dietary regimens; hypertension; intermittent fasting; obesity

Conflict of interest statement

MA and SS are involved in a patent application related to the cardiometabolic effects of caloric restriction mimetics. The remaining authors declare that the research was conducted in the absence of a

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