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Front Cardiovasc Med. 2021 Sep 29;8:722693. doi: 10.3389/fcvm.2021.722693. eCollection 2021.

How Transcatheter Aortic Valve Implantation (TAVI) Was Born: The Struggle for a New Invention.

Frontiers in cardiovascular medicine

Henning Rud Andersen

Affiliations

  1. Department of Cardiology, Research Unit, Aarhus University Hospital, Aarhus, Denmark.

PMID: 34660724 PMCID: PMC8511628 DOI: 10.3389/fcvm.2021.722693

Abstract

This story is about the invention of transcatheter aortic valve implantation (TAVI), and the people who transformed it from a concept and primitive device to a breakthrough lifesaving treatment for hundreds of thousands of patients with aortic valve stenosis. It is an inspirational example of a new disruptive technology that began with an idea most dismissed. The story describes the ups and downs from idea, design, construction, animal testing, proof-of-concept, scientific publication hurdles, a patent, license agreement, cooperation with several companies, fighting in patent courts in Europe and USA and finally how multinational companies financially bypassed the inventor. It is also a story about the struggles and battles the inventor experienced when injected into a world of lawyers and patent fights. I hope my personal story and journey can provide an inspiration and word of caution for new inventors.

Copyright © 2021 Andersen.

Keywords: TAVI; TAVR; aortic stenosis; development; history; invention; patent; transcatheter

Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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