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da Rocha JEB, Othman H, Botha G, et al. The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations. Front Pharmacol. 2021;12:634016doi: 10.3389/fphar.2021.634016.
da Rocha, J. E. B., Othman, H., Botha, G., Cottino, L., Twesigomwe, D., Ahmed, S., Drögemöller, B. I., Fadlelmola, F. M., Machanick, P., Mbiyavanga, M., Panji, S., Wright, G. E. B., Adebamowo, C., Matshaba, M., Ramsay, M., Simo, G., Simuunza, M. C., Tiemessen, C. T., Baldwin, S., Chiano, M., Cox, C., Gross, A. S., Thomas, P., Gamo, F. J., & Hazelhurst, S. (2021). The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations. Frontiers in pharmacology, 12634016. https://doi.org/10.3389/fphar.2021.634016
da Rocha, Jorge E B, et al. "The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations." Frontiers in pharmacology vol. 12 (2021): 634016. doi: https://doi.org/10.3389/fphar.2021.634016
da Rocha JEB, Othman H, Botha G, Cottino L, Twesigomwe D, Ahmed S, Drögemöller BI, Fadlelmola FM, Machanick P, Mbiyavanga M, Panji S, Wright GEB, Adebamowo C, Matshaba M, Ramsay M, Simo G, Simuunza MC, Tiemessen CT, Baldwin S, Chiano M, Cox C, Gross AS, Thomas P, Gamo FJ, Hazelhurst S. The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations. Front Pharmacol. 2021 Apr 28;12:634016. doi: 10.3389/fphar.2021.634016. eCollection 2021. PMID: 34721006; PMCID: PMC8549571.
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Front Pharmacol. 2021 Apr 28;12:634016. doi: 10.3389/fphar.2021.634016. eCollection 2021.

The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations.

Frontiers in pharmacology

Jorge E B da Rocha, Houcemeddine Othman, Gerrit Botha, Laura Cottino, David Twesigomwe, Samah Ahmed, Britt I Drögemöller, Faisal M Fadlelmola, Philip Machanick, Mamana Mbiyavanga, Sumir Panji, Galen E B Wright, Clement Adebamowo, Mogomotsi Matshaba, Michéle Ramsay, Gustave Simo, Martin C Simuunza, Caroline T Tiemessen, Sandra Baldwin, Mathias Chiano, Charles Cox, Annette S Gross, Pamela Thomas, Francisco-Javier Gamo, Scott Hazelhurst

Affiliations

  1. Sydney Brenner Institute for Molecular Bioscience (SBIMB), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  2. Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  3. Computational Biology Division and H3ABioNet, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.
  4. Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.
  5. Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
  6. Department of Computer Science, Rhodes University, Makhanda, South Africa.
  7. Neuroscience Research Program, Winnipeg Health Sciences Centre and Max Rady College of Medicine, Kleysen for Advanced Medicine, University of Manitoba, Winnipeg, MB, Canada.
  8. Department of Pharmacology and Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  9. Institute for Human Virology, Abuja, Nigeria.
  10. Institute of Human Virology and Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, United States.
  11. Botswana-Baylor Children's Clinical Center of Excellence, Gaborone, Botswana.
  12. Baylor College of Medicine, Houston, TX, United States.
  13. Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  14. Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
  15. Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Services and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  16. Drug Metabolism and Pharmacokinetics, GlaxoSmithKline R&D, Ware, United Kingdom.
  17. Human Genetics, GlaxoSmithKline R&D, Stevenage, United Kingdom.
  18. Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline R&D, Sydney, NSW, Australia.
  19. Data and Computational Sciences, GlaxoSmithKline R&D, Stevenage, United Kingdom.
  20. Global Health, GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain.
  21. School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa.

PMID: 34721006 PMCID: PMC8549571 DOI: 10.3389/fphar.2021.634016

[No abstract available.]

Copyright © 2021 da Rocha, Othman, Botha, Cottino, Twesigomwe, Ahmed, Drögemöller, Fadlelmola, Machanick, Mbiyavanga, Panji, Wright, Adebamowo, Matshaba, Ramsay, Simo, Simuunza, Tiemessen, Baldwin, Chiano, Cox, Gross, Thomas, Gamo and Hazelhurst.

Keywords: ADME; Africa; CNV; genetic diversity; pharmacogenomics

Conflict of interest statement

GlaxoSmithKline provided funding for this project. The authors SB, MC, CC, ASG, PT and FJG are all employees of GlaxoSmithKline and participated in the analysis and writing of the paper. GlaxoSmithKli

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