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El Kharraz S, Dubois V, van Royen ME, et al. The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation. EMBO Rep. 2021;22(12):e52764doi: 10.15252/embr.202152764.
El Kharraz, S., Dubois, V., van Royen, M. E., Houtsmuller, A. B., Pavlova, E., Atanassova, N., Nguyen, T., Voet, A., Eerlings, R., Handle, F., Prekovic, S., Smeets, E., Moris, L., Devlies, W., Ohlsson, C., Poutanen, M., Verstrepen, K. J., Carmeliet, G., Launonen, K. M., Helminen, L., Palvimo, J. J., Libert, C., Vanderschueren, D., Helsen, C., & Claessens, F. (2021). The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation. EMBO reports, 22(12), e52764. https://doi.org/10.15252/embr.202152764
El Kharraz, Sarah, et al. "The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation." EMBO reports vol. 22,12 (2021): e52764. doi: https://doi.org/10.15252/embr.202152764
El Kharraz S, Dubois V, van Royen ME, Houtsmuller AB, Pavlova E, Atanassova N, Nguyen T, Voet A, Eerlings R, Handle F, Prekovic S, Smeets E, Moris L, Devlies W, Ohlsson C, Poutanen M, Verstrepen KJ, Carmeliet G, Launonen KM, Helminen L, Palvimo JJ, Libert C, Vanderschueren D, Helsen C, Claessens F. The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation. EMBO Rep. 2021 Dec 06;22(12):e52764. doi: 10.15252/embr.202152764. Epub 2021 Oct 18. PMID: 34661369.
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EMBO Rep. 2021 Dec 06;22(12):e52764. doi: 10.15252/embr.202152764. Epub 2021 Oct 18.

The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation.

EMBO reports

Sarah El Kharraz, Vanessa Dubois, Martin E van Royen, Adriaan B Houtsmuller, Ekatarina Pavlova, Nina Atanassova, Tien Nguyen, Arnout Voet, Roy Eerlings, Florian Handle, Stefan Prekovic, Elien Smeets, Lisa Moris, Wout Devlies, Claes Ohlsson, Matti Poutanen, Kevin J Verstrepen, Geert Carmeliet, Kaisa-Mari Launonen, Laura Helminen, Jorma J Palvimo, Claude Libert, Dirk Vanderschueren, Christine Helsen, Frank Claessens

Affiliations

  1. Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
  2. Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
  3. Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
  4. Institute of Experimental Morphology Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria.
  5. Department of Chemistry, KU Leuven, Leuven, Belgium.
  6. Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  7. Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden.
  8. Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland.
  9. VIB Laboratory for Systems Biology and KU Leuven Laboratory for Genetics and Genomics, VIB - KU Leuven Center for Microbiology, Leuven, Belgium.
  10. Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
  11. VIB Center for Inflammation Research, VIB, Ghent, Belgium.
  12. Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

PMID: 34661369 DOI: 10.15252/embr.202152764

Abstract

Whereas dimerization of the DNA-binding domain of the androgen receptor (AR) plays an evident role in recognizing bipartite response elements, the contribution of the dimerization of the ligand-binding domain (LBD) to the correct functioning of the AR remains unclear. Here, we describe a mouse model with disrupted dimerization of the AR LBD (AR

© 2021 The Authors.

Keywords: androgen receptor; chromatin binding; dimerization; ligand-binding domain; transcriptional activation

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