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Mirahmadi Y, Nabavi R, Taheri F, et al. MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer. J Oncol. 2021;2021:3408937doi: 10.1155/2021/3408937.
Mirahmadi, Y., Nabavi, R., Taheri, F., Samadian, M. M., Ghale-Noie, Z. N., Farjami, M., Samadi-Khouzani, A., Yousefi, M., Azhdari, S., Salmaninejad, A., & Sahebkar, A. (2021). MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer. Journal of oncology, 20213408937. https://doi.org/10.1155/2021/3408937
Mirahmadi, Yegane, et al. "MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer." Journal of oncology vol. 2021 (2021): 3408937. doi: https://doi.org/10.1155/2021/3408937
Mirahmadi Y, Nabavi R, Taheri F, Samadian MM, Ghale-Noie ZN, Farjami M, Samadi-Khouzani A, Yousefi M, Azhdari S, Salmaninejad A, Sahebkar A. MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer. J Oncol. 2021 Oct 21;2021:3408937. doi: 10.1155/2021/3408937. eCollection 2021. PMID: 34721577; PMCID: PMC8553480.
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J Oncol. 2021 Oct 21;2021:3408937. doi: 10.1155/2021/3408937. eCollection 2021.

MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer.

Journal of oncology

Yegane Mirahmadi, Reza Nabavi, Fourough Taheri, Mohammad Mahdi Samadian, Zari Naderi Ghale-Noie, Mahsa Farjami, Abbas Samadi-Khouzani, Meysam Yousefi, Sara Azhdari, Arash Salmaninejad, Amirhossein Sahebkar

Affiliations

  1. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  2. Medical Genetics Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. University of Nebraska, Lincoln, NE, USA.
  4. Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
  5. Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  6. Department of Anatomy and Embryology, School of Medicine, Bam University of Medical Sciences, Bam, Iran.
  7. Department of Medical Genetics, Faculty of Medicine, Guilan University of Medical Sciences, Guilan, Iran.
  8. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
  10. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 34721577 PMCID: PMC8553480 DOI: 10.1155/2021/3408937

Abstract

Ovarian cancer is the major cause of gynecologic cancer-related mortality. Regardless of outstanding advances, which have been made for improving the prognosis, diagnosis, and treatment of ovarian cancer, the majority of the patients will die of the disease. Late-stage diagnosis and the occurrence of recurrent cancer after treatment are the most important causes of the high mortality rate observed in ovarian cancer patients. Unraveling the molecular mechanisms involved in the pathogenesis of ovarian cancer may help find new biomarkers and therapeutic targets for ovarian cancer. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression, mostly at the posttranscriptional stage, through binding to mRNA targets and inducing translational repression or degradation of target via the RNA-induced silencing complex. Over the last two decades, the role of miRNAs in the pathogenesis of various human cancers, including ovarian cancer, has been documented in multiple studies. Consequently, these small RNAs could be considered as reliable markers for prognosis and early diagnosis. Furthermore, given the function of miRNAs in various cellular pathways, including cell survival and differentiation, targeting miRNAs could be an interesting approach for the treatment of human cancers. Here, we review our current understanding of the most updated role of the important dysregulation of miRNAs and their roles in the progression and metastasis of ovarian cancer. Furthermore, we meticulously discuss the significance of miRNAs as prognostic and diagnostic markers. Lastly, we mention the opportunities and the efforts made for targeting ovarian cancer through inhibition and/or stimulation of the miRNAs.

Copyright © 2021 Yegane Mirahmadi et al.

Conflict of interest statement

The authors declare no conflicts of interest.

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