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Val DD, Abdel-Wahab M, Mangner N, et al. Infective Endocarditis Caused by Staphylococcus Aureus after Transcatheter Aortic Valve Replacement. Can J Cardiol. 2021;doi: 10.1016/j.cjca.2021.10.004.
Val, D. D., Abdel-Wahab, M., Mangner, N., Durand, E., Ihlemann, N., Urena, M., Pellegrini, C., Giannini, F., Gasior, T., Wojakowski, W., Landt, M., Auffret, V., Sinning, J. M., Cheema, A. N., Nombela-Franco, L., Chamandi, C., Campelo-Parada, F., Munoz-Garcia, E., Herrmann, H. C., Testa, L., Won-Keun, K., Castillo, J. C., Alperi, A., Tchetche, D., Bartorelli, A. L., Kapadia, S., Stortecky, S., Amat-Santos, I., Wijeysundera, H. C., Lisko, J., Gutiérrez-Ibanes, E., Serra, V., Salido, L., Alkhodair, A., Vendramin, I., Chakravarty, T., Lerakis, S., Vilalta, V., Regueiro, A., Romaguera, R., Kappert, U., Barbanti, M., Masson, J. B., Maes, F., Fiorina, C., Miceli, A., Kodali, S., Ribeiro, H. B., Mangione, J. A., Sandoli de Brito, F., Actis Dato, G. M., Rosato, F., Ferreira, M. C., Corriea de Lima, V., Colafranceschi, A. S., Abizaid, A., Marino, M. A., Esteves, V., Andrea, J., Godinho, R. R., Alfonso, F., Eltchaninoff, H., Søndergaard, L., Himbert, D., Husser, O., Latib, A., Le Breton, H., Servoz, C., Pascual, I., Siddiqui, S., Olivares, P., Hernandez-Antolin, R., Webb, J. G., Sponga, S., Makkar, R., Kini, A. S., Boukhris, M., Gervais, P., Linke, A., Crusius, L., Holzhey, D., & Rodés-Cabau, J. (2021). Infective Endocarditis Caused by Staphylococcus Aureus after Transcatheter Aortic Valve Replacement. The Canadian journal of cardiology, . https://doi.org/10.1016/j.cjca.2021.10.004
Val, David Del, et al. "Infective Endocarditis Caused by Staphylococcus Aureus after Transcatheter Aortic Valve Replacement." The Canadian journal of cardiology vol. (2021). doi: https://doi.org/10.1016/j.cjca.2021.10.004
Val DD, Abdel-Wahab M, Mangner N, Durand E, Ihlemann N, Urena M, Pellegrini C, Giannini F, Gasior T, Wojakowski W, Landt M, Auffret V, Sinning JM, Cheema AN, Nombela-Franco L, Chamandi C, Campelo-Parada F, Munoz-Garcia E, Herrmann HC, Testa L, Won-Keun K, Castillo JC, Alperi A, Tchetche D, Bartorelli AL, Kapadia S, Stortecky S, Amat-Santos I, Wijeysundera HC, Lisko J, Gutiérrez-Ibanes E, Serra V, Salido L, Alkhodair A, Vendramin I, Chakravarty T, Lerakis S, Vilalta V, Regueiro A, Romaguera R, Kappert U, Barbanti M, Masson JB, Maes F, Fiorina C, Miceli A, Kodali S, Ribeiro HB, Mangione JA, Sandoli de Brito F, Actis Dato GM, Rosato F, Ferreira MC, Corriea de Lima V, Colafranceschi AS, Abizaid A, Marino MA, Esteves V, Andrea J, Godinho RR, Alfonso F, Eltchaninoff H, Søndergaard L, Himbert D, Husser O, Latib A, Le Breton H, Servoz C, Pascual I, Siddiqui S, Olivares P, Hernandez-Antolin R, Webb JG, Sponga S, Makkar R, Kini AS, Boukhris M, Gervais P, Linke A, Crusius L, Holzhey D, Rodés-Cabau J. Infective Endocarditis Caused by Staphylococcus Aureus after Transcatheter Aortic Valve Replacement. Can J Cardiol. 2021 Oct 21; doi: 10.1016/j.cjca.2021.10.004. Epub 2021 Oct 21. PMID: 34688853.
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Can J Cardiol. 2021 Oct 21; doi: 10.1016/j.cjca.2021.10.004. Epub 2021 Oct 21.

Infective Endocarditis Caused by Staphylococcus Aureus after Transcatheter Aortic Valve Replacement.

The Canadian journal of cardiology

David Del Val, Mohamed Abdel-Wahab, Norman Mangner, Eric Durand, Nikolaj Ihlemann, Marina Urena, Costanza Pellegrini, Francesco Giannini, Tomasz Gasior, Wojtek Wojakowski, Martin Landt, Vincent Auffret, Jan Malte Sinning, Asim N Cheema, Luis Nombela-Franco, Chekrallah Chamandi, Francisco Campelo-Parada, Erika Munoz-Garcia, Howard C Herrmann, Luca Testa, Kim Won-Keun, Juan Carlos Castillo, Alberto Alperi, Didier Tchetche, Antonio L Bartorelli, Samir Kapadia, Stefan Stortecky, Ignacio Amat-Santos, Harindra C Wijeysundera, John Lisko, Enrique Gutiérrez-Ibanes, Vicenç Serra, Luisa Salido, Abdullah Alkhodair, Igor Vendramin, Tarun Chakravarty, Stamatios Lerakis, Victoria Vilalta, Ander Regueiro, Rafael Romaguera, Utz Kappert, Marco Barbanti, Jean-Bernard Masson, Frédéric Maes, Claudia Fiorina, Antonio Miceli, Susheel Kodali, Henrique B Ribeiro, Jose Armando Mangione, Fabio Sandoli de Brito, Guglielmo Mario Actis Dato, Francesco Rosato, Maria-Cristina Ferreira, Valter Corriea de Lima, Alexandre Siciliano Colafranceschi, Alexandre Abizaid, Marcos Antonio Marino, Vinicius Esteves, Julio Andrea, Roger R Godinho, Fernando Alfonso, Helene Eltchaninoff, Lars Søndergaard, Dominique Himbert, Oliver Husser, Azeem Latib, Hervé Le Breton, Clement Servoz, Isaac Pascual, Saif Siddiqui, Paolo Olivares, Rosana Hernandez-Antolin, John G Webb, Sandro Sponga, Raj Makkar, Annapoorna S Kini, Marouane Boukhris, Philippe Gervais, Axel Linke, Lisa Crusius, David Holzhey, Josep Rodés-Cabau

Affiliations

  1. Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada.
  2. Heart Center, Leipzig University, Leipzig, Germany; Heart Center, Segeberger Kliniken, Bad Segeberg, Germany.
  3. Heart Center, Leipzig University, Leipzig, Germany; Herzzentrum Dresden, Technische Universität Dresden, Germany.
  4. Normandie Univ, UNIROUEN, U1096, CHU Rouen, Department of Cardiology, FHU CARNAVAL, F-76000 Rouen, France.
  5. Righospitalet, Copenhagen, Denmark.
  6. Bichat Hôpital, Paris, France.
  7. Deutsches Herzzentrum München, Munich, Germany.
  8. Ospedale San Raffaele, Milan, Italy; Maria Cecilia Hospital, GVM Care and Research, Cotignola RA, Italy.
  9. Herzzentrum Dresden, Technische Universität Dresden, Germany.
  10. Medical University of Silesia, Katowice, Poland.
  11. Heart Center, Segeberger Kliniken, Bad Segeberg, Germany.
  12. Univ Rennes, CHU Rennes, Inserm, LTSI - UMR1099, F 35000 Rennes, France.
  13. Heart Center Bonn, Bonn, Germany.
  14. St Michaels Hospital, Toronto, Canada; Southlake Hospital, Newmarket, Ontario, Canada.
  15. Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
  16. Hôpital Européen Georges-Pompidou, Paris, France.
  17. Hôpital Rangueil, Toulouse, France.
  18. Hospital Universitario Virgen de la Victoria, Malaga, Spain.
  19. Hospital of the University of Pennsilvania, Philadelphia, USA.
  20. IRCCS Pol. San Donato, Milan, Italy.
  21. Kerckhoff Heart and Thorax Centre, Bad Nauheim, Germany.
  22. Hospital Universitario Reina Sofia, Cordoba, Spain.
  23. Hospital Universitario Central de Asturias, Oviedo, Spain.
  24. Clinique Pasteur, Toulouse, France.
  25. Centro Cardiologico Monzino, IRCCS and Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy.
  26. Cleveland Clinic, Cleveland, USA.
  27. Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (on behalf of Swiss TAVI).
  28. CIBERCV, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.
  29. Sunnybrook Health Science Center, Toronto, Canada.
  30. Emory University School of Medicine, Atlanta, USA.
  31. Instituto de Investigación Universitaria Gregorio Marañon, Hospital Gregorio Marañón, Madrid, Spain.
  32. Hospital Vall d'Hebron, Barcelona, Spain.
  33. Hospital Universitario Ramón y Cajal, Madrid, Spain.
  34. St Paul's Hospital, Vancouver, Canada.
  35. University Hospital of Udine, Udine, Italy.
  36. Cedars-Sinai Heart Institute, Los Angeles, USA.
  37. Emory University School of Medicine, Atlanta, USA; Mount Sinai Hospital, New York, NY, USA.
  38. Hospital Germans Trias i Pujol, Badalona, Spain.
  39. Hospital Clinic, Barcelona, Spain.
  40. Hospital de Bellvitge; L'Hospitalet de Llobregat, Spain.
  41. A.O.U. Policlinico Vittorio Emanuele, University of Catania, Catania, Italy.
  42. Centre Hospitalier de l'Université de Montreal, Montreal, Canada.
  43. Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  44. ASST-Spedali Civili di Brescia, Brescia, Italy.
  45. Istituto Clinico Sant'Ambrogio, Milan, Italy; University Hospital Galway, Galway, Ireland.
  46. Columbia University Medical Center, New York, USA.
  47. InCor, Heart Institute, University of São Paulo Medical School, Sao Paulo, Brazil; Hospital Samaritano Paulista, Sao Paulo, Brazil.
  48. Hospital Beneficencia Portuguesa, Sao Paulo, Brazil.
  49. InCor, Heart Institute, University of São Paulo Medical School, Sao Paulo, Brazil.
  50. Ospedali Mauriziano, Torino, Italy.
  51. Azienda Ospedaliera S. Cocre e Carle Cuneo, Cuneo, Italy.
  52. Hospital Naval Marcilio Dias, Rio de Janeiro, Brazil.
  53. Hospital São Francisco-Santa Casa de Porto Alegre, Porto Alegre, Brazil.
  54. Hospital Pró-cardíaco, Rio de Janeiro, Brazil.
  55. Hospital Madre Teresa, Belo Horizonte, Brazil.
  56. Hospital Sao Luiz, Sao Paulo, Brazil.
  57. Clínica Sao Vicente, Rio de Janeiro, Brazil.
  58. Hospital Samaritano Paulista, Sao Paulo, Brazil.
  59. Hospital Universitario La Princesa, Madrid, Spain.
  60. Deutsches Herzzentrum München, Munich, Germany; St.-Johannes-Hospital, Dortmund, Germany.
  61. Ospedale San Raffaele, Milan, Italy; Montefiore Medical Center, New York, NY, USA.
  62. Mount Sinai Hospital, New York, NY, USA.
  63. Heart Center, Leipzig University, Leipzig, Germany.
  64. Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address: [email protected].

PMID: 34688853 DOI: 10.1016/j.cjca.2021.10.004

Abstract

BACKGROUND: Staphylococcus aureus (S aureus) has been extensively studied as causative microorganism of surgical prosthetic-valve infective endocarditis (IE). However, scarce evidence exists on S aureus IE after transcatheter aortic valve replacement (TAVR).

METHODS: Data was obtained from the Infectious Endocarditis after TAVR International Registry including patients with definite IE following TAVR from 59 centers in 11 countries. Patients were divided into two groups according to microbiological etiology (non-S aureus-IE, non-SA-IE vs. S aureus-IE, SA-IE).

RESULTS: SA-IE was identified in 141 out of 573 (24.6%) patients, methicillin-sensitive S aureus in most cases (115/141, 81.6%). SEV were more common than BEV in patients with early SA-IE. Major bleeding and sepsis complicating TAVR, neurological symptoms or systemic embolism at admission and IE with cardiac device involvement other than the TAVR prosthesis were associated with SA-IE (p<0.05 for all). Among IE post-TAVR patients, the likelihood of SA-IE increased from 19% in the absence of those risk factors to 84.6% if ≥3 risk factors were present. In-hospital (47.8% vs. 26.9%, p<0.001) and 2-year mortality (71.5% vs. 49.6%, p<0.001) rates were higher among SA-IE (vs. non-SA-IE) patients. Surgery at the time of index SA-IE was associated with a lower mortality rate at follow-up (HR

CONCLUSIONS: SA-IE represented ∼ 25% of IE cases after TAVR and was associated with a very high in-hospital and late mortality. The presence of some features determined a higher likelihood of SA-IE and could help to orientate early antibiotic regimen selection. Surgery at index SA-IE was associated with improved outcomes, and its role should be evaluated in future studies.

Copyright © 2021. Published by Elsevier Inc.

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