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McQuilten ZK, Flint AW, Green L, et al. Epidemiology of Massive Transfusion - A Common Intervention in Need of a Definition. Transfus Med Rev. 2021;35(4):73-79doi: 10.1016/j.tmrv.2021.08.006.
McQuilten, Z. K., Flint, A. W., Green, L., Sanderson, B., Winearls, J., & Wood, E. M. (2021). Epidemiology of Massive Transfusion - A Common Intervention in Need of a Definition. Transfusion medicine reviews, 35(4), 73-79. https://doi.org/10.1016/j.tmrv.2021.08.006
McQuilten, Zoe K, et al. "Epidemiology of Massive Transfusion - A Common Intervention in Need of a Definition." Transfusion medicine reviews vol. 35,4 (2021): 73-79. doi: https://doi.org/10.1016/j.tmrv.2021.08.006
McQuilten ZK, Flint AW, Green L, Sanderson B, Winearls J, Wood EM. Epidemiology of Massive Transfusion - A Common Intervention in Need of a Definition. Transfus Med Rev. 2021 Oct;35(4):73-79. doi: 10.1016/j.tmrv.2021.08.006. Epub 2021 Oct 21. PMID: 34690031.
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Transfus Med Rev. 2021 Oct;35(4):73-79. doi: 10.1016/j.tmrv.2021.08.006. Epub 2021 Oct 21.

Epidemiology of Massive Transfusion - A Common Intervention in Need of a Definition.

Transfusion medicine reviews

Zoe K McQuilten, Andrew Wj Flint, Laura Green, Brenton Sanderson, James Winearls, Erica M Wood

Affiliations

  1. Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Clinical Haematology, Monash Health, Melbourne, Australia; The Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: [email protected].
  2. Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; The Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Intensive Care Unit, Royal Darwin Hospital, Northern Territory, Australia.
  3. Blizard Institute, Queen Mary University of London, London, UK; NHS Blood and Transplant, London, UK; Barts Health NHS Trust, London, UK.
  4. Department of Anaesthesia and Perioperative Medicine, Westmead Hospital, Sydney, Australia; Centre for Health Informatics, Australian Institute of Health Innovation, Macquarie University, Sydney, Australia.
  5. Department of Intensive Care Unit, Gold Coast University Hospital, Gold Coast, Australia; School of Medicine, University of Queensland, Brisbane, Australia; School of Medical Sciences, Griffith University, Gold Coast, Australia; Department of Intensive Care Unit, St Andrew's War Memorial Hospital, Brisbane, Australia.
  6. Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Clinical Haematology, Monash Health, Melbourne, Australia.

PMID: 34690031 DOI: 10.1016/j.tmrv.2021.08.006

Abstract

While massive transfusion (MT) recipients account for a small proportion of all transfused patients, they account for approximately 10% of blood products issued. Furthermore, MT events pose organizational and logistical challenges for health care providers, laboratory and transfusion services. Overall, the majority of MT events are to support major bleeding in surgical patients, trauma and gastrointestinal hemorrhage. The clinical context in which the bleeding event occurred, the number of blood products required, patient age and comorbidities are the most important predictors of outcomes for short- and long-term survival. These data are important to inform blood services, clinicians and health care providers in order to improve care and outcomes for patients with major bleeding. There is no standard accepted definition of MT, with most definitions based on number of blood components administered within a certain time-period or activation of MT protocol. The type of definition used has implications for the clinical characteristics of MT recipients included in epidemiological and interventional studies. In order to understand trends in incidence of MT, variation in blood utilization and patient outcomes, and to harmonize research outcomes, a standard and universally accepted definition of MT is urgently required.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Epidemiology; Major bleeding; Massive transfusion; Red cell transfusion

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