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Zhang L, Zhou D, Li Q, et al. The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses. Front Microbiol. 2021;12:727236doi: 10.3389/fmicb.2021.727236.
Zhang, L., Zhou, D., Li, Q., Zhu, S., Imran, M., Duan, H., Cao, S., Ke, S., & Ye, J. (2021). The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses. Frontiers in microbiology, 12727236. https://doi.org/10.3389/fmicb.2021.727236
Zhang, Luping, et al. "The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses." Frontiers in microbiology vol. 12 (2021): 727236. doi: https://doi.org/10.3389/fmicb.2021.727236
Zhang L, Zhou D, Li Q, Zhu S, Imran M, Duan H, Cao S, Ke S, Ye J. The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses. Front Microbiol. 2021 Oct 06;12:727236. doi: 10.3389/fmicb.2021.727236. eCollection 2021. PMID: 34690968; PMCID: PMC8527100.
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Front Microbiol. 2021 Oct 06;12:727236. doi: 10.3389/fmicb.2021.727236. eCollection 2021.

The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses.

Frontiers in microbiology

Luping Zhang, Dengyuan Zhou, Qiuyan Li, Shuo Zhu, Muhammad Imran, Hongyu Duan, Shengbo Cao, Shaoyong Ke, Jing Ye

Affiliations

  1. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
  2. Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
  3. The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, China.
  4. National Biopesticide Engineering Research Center, Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan, China.

PMID: 34690968 PMCID: PMC8527100 DOI: 10.3389/fmicb.2021.727236

Abstract

Flaviviruses are the major emerging arthropod-borne pathogens globally. However, there is still no practical anti-flavivirus approach. Therefore, existing and emerging flaviviruses desperately need active broad-spectrum drugs. In the present study, the antiviral effect of steroidal dehydroepiandrosterone (DHEA) and 23 synthetic derivatives against flaviviruses such as Japanese encephalitis virus (JEV), Zika virus (ZIKV), and Dengue virus (DENV) were appraised by examining the characteristics of virus infection both

Copyright © 2021 Zhang, Zhou, Li, Zhu, Imran, Duan, Cao, Ke and Ye.

Keywords: DHEA derivatives; antiviral activity; flavivirus; steroids; therapy

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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