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Goo H, Mo S, Park HJ, et al. Treatment with LEDs at a wavelength of 642 nm enhances skin tumor proliferation in a mouse model. Biomed Opt Express. 2021;12(9):5583-5596doi: 10.1364/BOE.427205.
Goo, H., Mo, S., Park, H. J., Lee, M. Y., & Ahn, J. C. (2021). Treatment with LEDs at a wavelength of 642 nm enhances skin tumor proliferation in a mouse model. Biomedical optics express, 12(9), 5583-5596. https://doi.org/10.1364/BOE.427205
Goo, Hyeyoon, et al. "Treatment with LEDs at a wavelength of 642 nm enhances skin tumor proliferation in a mouse model." Biomedical optics express vol. 12,9 (2021): 5583-5596. doi: https://doi.org/10.1364/BOE.427205
Goo H, Mo S, Park HJ, Lee MY, Ahn JC. Treatment with LEDs at a wavelength of 642 nm enhances skin tumor proliferation in a mouse model. Biomed Opt Express. 2021 Aug 13;12(9):5583-5596. doi: 10.1364/BOE.427205. eCollection 2021 Sep 01. PMID: 34692202; PMCID: PMC8515971.
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Biomed Opt Express. 2021 Aug 13;12(9):5583-5596. doi: 10.1364/BOE.427205. eCollection 2021 Sep 01.

Treatment with LEDs at a wavelength of 642 nm enhances skin tumor proliferation in a mouse model.

Biomedical optics express

Hyeyoon Goo, SangJoon Mo, Hyeong Ju Park, Min Young Lee, Jin-Chul Ahn

Affiliations

  1. Department of Medical Laser, Graduate School of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
  2. Medical Laser Research Center, Dankook University, Cheonan 31116, Republic of Korea.
  3. Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
  4. Beckman Laser Institute Korea, Dankook University, Cheonan 31116, Republic of Korea.
  5. Contributed equally.

PMID: 34692202 PMCID: PMC8515971 DOI: 10.1364/BOE.427205

Abstract

Photobiomodulation (PBM) is attracting increased attention in the fields of dermatology and cosmetics. PBM with a variety of light parameters has been used widely in skin care, but can cause certain types of unwanted cells to proliferate in the skin; this can lead to skin tumors, such as papillomas and cancers. We constructed a mouse model of human skin tumors using DMBA as an initiator and TPA as a promoter, and confirmed that LEDs with a wavelength of 642 nm (red light) increased tumor size, epidermal thickness, and systemic proinflammatory cytokine levels. These results indicated that skin tumor cell proliferation may result from the use of 642 nm LEDs, suggesting the need for regulation of skin care based on LED light therapy.

© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.

Conflict of interest statement

All Authors of this manuscript declare that there are no conflicts of interest regarding this study.

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