Cochrane Database Syst Rev. 2021 Nov 17;11:CD008521. doi: 10.1002/14651858.CD008521.pub6.
Vaccines for preventing rotavirus diarrhoea: vaccines in use.
The Cochrane database of systematic reviews
Hanna Bergman, Nicholas Henschke, Daniel Hungerford, Femi Pitan, Duduzile Ndwandwe, Nigel Cunliffe, Karla Soares-Weiser
Affiliations
Affiliations
- Cochrane Response, Cochrane, London, UK.
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
- NIHR Health Protection Research Unit in Gastrointestinal Infections, University of Liverpool, Liverpool, UK.
- Chevron Corporation, Lagos, Nigeria.
- Cochrane South Africa, South African Medical Research Council , Cape Town, South Africa.
- Editorial & Methods Department, Cochrane, London, UK.
PMID: 34788488
PMCID: PMC8597890 DOI: 10.1002/14651858.CD008521.pub6
Abstract
BACKGROUND: Rotavirus is a common cause of diarrhoea, diarrhoea-related hospital admissions, and diarrhoea-related deaths worldwide. Rotavirus vaccines prequalified by the World Health Organization (WHO) include Rotarix (GlaxoSmithKline), RotaTeq (Merck), and, more recently, Rotasiil (Serum Institute of India Ltd.), and Rotavac (Bharat Biotech Ltd.).
OBJECTIVES: To evaluate rotavirus vaccines prequalified by the WHO for their efficacy and safety in children.
SEARCH METHODS: On 30 November 2020, we searched PubMed, the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (published in the Cochrane Library), Embase, LILACS, Science Citation Index Expanded, Social Sciences Citation Index, Conference Proceedings Citation Index-Science, Conference Proceedings Citation Index-Social Science & Humanities. We also searched the WHO ICTRP, ClinicalTrials.gov, clinical trial reports from manufacturers' websites, and reference lists of included studies, and relevant systematic reviews.
SELECTION CRITERIA: We selected randomized controlled trials (RCTs) conducted in children that compared rotavirus vaccines prequalified for use by the WHO with either placebo or no intervention.
DATA COLLECTION AND ANALYSIS: Two authors independently assessed trial eligibility and assessed risk of bias. One author extracted data and a second author cross-checked them. We combined dichotomous data using the risk ratio (RR) and 95% confidence interval (CI). We stratified the analyses by under-five country mortality rate and used GRADE to evaluate evidence certainty.
MAIN RESULTS: Sixty trials met the inclusion criteria and enrolled a total of 228,233 participants. Thirty-six trials (119,114 participants) assessed Rotarix, 15 trials RotaTeq (88,934 participants), five trials Rotasiil (11,753 participants), and four trials Rotavac (8432 participants). Rotarix Infants vaccinated and followed up for the first year of life In low-mortality countries, Rotarix prevented 93% of severe rotavirus diarrhoea cases (14,976 participants, 4 trials; high-certainty evidence), and 52% of severe all-cause diarrhoea cases (3874 participants, 1 trial; moderate-certainty evidence). In medium-mortality countries, Rotarix prevented 79% of severe rotavirus diarrhoea cases (31,671 participants, 4 trials; high-certainty evidence), and 36% of severe all-cause diarrhoea cases (26,479 participants, 2 trials; high-certainty evidence). In high-mortality countries, Rotarix prevented 58% of severe rotavirus diarrhoea cases (15,882 participants, 4 trials; high-certainty evidence), and 27% of severe all-cause diarrhoea cases (5639 participants, 2 trials; high-certainty evidence). Children vaccinated and followed up for two years In low-mortality countries, Rotarix prevented 90% of severe rotavirus diarrhoea cases (18,145 participants, 6 trials; high-certainty evidence), and 51% of severe all-cause diarrhoea episodes (6269 participants, 2 trials; moderate-certainty evidence). In medium-mortality countries, Rotarix prevented 77% of severe rotavirus diarrhoea cases (28,834 participants, 3 trials; high-certainty evidence), and 26% of severe all-cause diarrhoea cases (23,317 participants, 2 trials; moderate-certainty evidence). In high-mortality countries, Rotarix prevented 35% of severe rotavirus diarrhoea cases (13,768 participants, 2 trials; moderate-certainty evidence), and 17% of severe all-cause diarrhoea cases (2764 participants, 1 trial; high-certainty evidence). RotaTeq Infants vaccinated and followed up for the first year of life In low-mortality countries, RotaTeq prevented 97% of severe rotavirus diarrhoea cases (5442 participants, 2 trials; high-certainty evidence). In medium-mortality countries, RotaTeq prevented 79% of severe rotavirus diarrhoea cases (3863 participants, 1 trial; low-certainty evidence). In high-mortality countries, RotaTeq prevented 57% of severe rotavirus diarrhoea cases (6775 participants, 2 trials; high-certainty evidence), but there is probably little or no difference between vaccine and placebo for severe all-cause diarrhoea (1 trial, 4085 participants; moderate-certainty evidence). Children vaccinated and followed up for two years In low-mortality countries, RotaTeq prevented 96% of severe rotavirus diarrhoea cases (5442 participants, 2 trials; high-certainty evidence). In medium-mortality countries, RotaTeq prevented 79% of severe rotavirus diarrhoea cases (3863 participants, 1 trial; low-certainty evidence). In high-mortality countries, RotaTeq prevented 44% of severe rotavirus diarrhoea cases (6744 participants, 2 trials; high-certainty evidence), and 15% of severe all-cause diarrhoea cases (5977 participants, 2 trials; high-certainty evidence). We did not identify RotaTeq studies reporting on severe all-cause diarrhoea in low- or medium-mortality countries. Rotasiil Rotasiil has not been assessed in any RCT in countries with low or medium child mortality. Infants vaccinated and followed up for the first year of life In high-mortality countries, Rotasiil prevented 48% of severe rotavirus diarrhoea cases (11,008 participants, 2 trials; high-certainty evidence), and resulted in little to no difference in severe all-cause diarrhoea cases (11,008 participants, 2 trials; high-certainty evidence). Children vaccinated and followed up for two years In high-mortality countries, Rotasiil prevented 44% of severe rotavirus diarrhoea cases (11,008 participants, 2 trials; high-certainty evidence), and resulted in little to no difference in severe all-cause diarrhoea cases (11,008 participants, 2 trials; high-certainty evidence). Rotavac Rotavac has not been assessed in any RCT in countries with low or medium child mortality. Infants vaccinated and followed up for the first year of life In high-mortality countries, Rotavac prevented 57% of severe rotavirus diarrhoea cases (6799 participants, 1 trial; moderate-certainty evidence), and 16% of severe all-cause diarrhoea cases (6799 participants, 1 trial; moderate-certainty evidence). Children vaccinated and followed up for two years In high-mortality countries, Rotavac prevented 54% of severe rotavirus diarrhoea cases (6541 participants, 1 trial; moderate-certainty evidence); no Rotavac studies have reported on severe all-cause diarrhoea at two-years follow-up. Safety No increased risk of serious adverse events (SAEs) was detected with Rotarix (103,714 participants, 31 trials; high-certainty evidence), RotaTeq (82,502 participants, 14 trials; moderate to high-certainty evidence), Rotasiil (11,646 participants, 3 trials; high-certainty evidence), or Rotavac (8210 participants, 3 trials; moderate-certainty evidence). Deaths were infrequent and the analysis had insufficient evidence to show an effect on all-cause mortality. Intussusception was rare. AUTHORS' CONCLUSIONS: Rotarix, RotaTeq, Rotasiil, and Rotavac prevent episodes of rotavirus diarrhoea. The relative effect estimate is smaller in high-mortality than in low-mortality countries, but more episodes are prevented in high-mortality settings as the baseline risk is higher. In high-mortality countries some results suggest lower efficacy in the second year. We found no increased risk of serious adverse events, including intussusception, from any of the prequalified rotavirus vaccines.
Copyright © 2021 The Authors. Cochrane Database of Systematic Reviews published by John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration.
References
- Vaccine. 2012 Apr 27;30 Suppl 1:A36-43 - PubMed
- Hum Vaccin. 2010 Mar 26;6(3): - PubMed
- Hum Vaccin Immunother. 2021 Apr 3;17(4):1223-1234 - PubMed
- Eur J Pediatr. 2010 Nov;169(11):1379-86 - PubMed
- Cochrane Database Syst Rev. 2010 May 12;(5):CD008521 - PubMed
- J Infect Dis. 2014 Dec 1;210(11):1772-9 - PubMed
- J Infect Dis. 2010 Sep 1;202 Suppl:S93-100 - PubMed
- Lancet. 2010 Aug 21;376(9741):615-23 - PubMed
- BMC Pediatr. 2017 Jan 13;17(1):14 - PubMed
- N Engl J Med. 2006 Jan 5;354(1):23-33 - PubMed
- Ann Acad Med Singap. 2006 Jan;35(1):38-44 - PubMed
- Ann Acad Med Singap. 2008 Jul;37(7):546-53 - PubMed
- N Engl J Med. 2018 Feb 22;378(8):719-730 - PubMed
- N Engl J Med. 2010 Jan 28;362(4):289-98 - PubMed
- Lancet. 2007 Nov 24;370(9601):1757-63 - PubMed
- Lancet. 2014 Jun 21;383(9935):2136-43 - PubMed
- Vaccine. 2019 May 1;37(19):2554-2560 - PubMed
- Vaccine. 2014 Aug 11;32 Suppl 1:A134-9 - PubMed
- Pediatr Infect Dis J. 2009 Mar;28(3):177-81 - PubMed
- Vaccine. 2014 Aug 11;32 Suppl 1:A110-6 - PubMed
- Cochrane Database Syst Rev. 2012 Nov 14;11:CD008521 - PubMed
- Vaccine. 2014 Aug 11;32 Suppl 1:A117-23 - PubMed
- J Pediatr. 2006 Jul;149(1):143 - PubMed
- Vaccine. 2010 Sep 7;28(39):6542-8 - PubMed
- MMWR Recomm Rep. 2006 Aug 11;55(RR-12):1-13 - PubMed
- Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671): - PubMed
- Pediatrics. 2008 Nov;122(5):e1062-6 - PubMed
- Vaccine. 2015 Jan 1;33(1):52-61 - PubMed
- Heliyon. 2017 May 16;3(5):e00302 - PubMed
- Hum Vaccin. 2009 Jun;5(6):414-9 - PubMed
- J Infect Dis. 2013 Aug 1;208(3):423-31 - PubMed
- BMC Pediatr. 2010 Jun 11;10:42 - PubMed
- N Engl J Med. 2010 Jan 28;362(4):299-305 - PubMed
- Lancet. 2008 Apr 5;371(9619):1181-9 - PubMed
- Pediatr Infect Dis J. 2004 Oct;23(10):937-43 - PubMed
- Hum Vaccin Immunother. 2013 Aug;9(8):1638-42 - PubMed
- J Infect Dis. 2009 Aug 1;200(3):421-9 - PubMed
- Scand J Infect Dis. 1990;22(3):259-67 - PubMed
- J Infect Dis. 2007 Aug 15;196(4):537-40 - PubMed
- Rev Gastroenterol Peru. 2012 Jan-Mar;32(1):11-5 - PubMed
- Pediatr Infect Dis J. 2017 Apr;36(4):417-422 - PubMed
- Ann Acad Med Singap. 2016 Feb;45(2):44-50 - PubMed
- AIDS. 2017 Jan 2;31(1):49-59 - PubMed
- Vaccine. 2006 May 1;24(18):3784-5 - PubMed
- Nat Rev Dis Primers. 2017 Nov 09;3:17083 - PubMed
- Lancet. 1997 Nov 22;350(9090):1538-41 - PubMed
- Sci Transl Med. 2019 Aug 14;11(505): - PubMed
- Lancet Infect Dis. 2015 Dec;15(12):1389-97 - PubMed
- Pediatr Infect Dis J. 2016 Sep;35(9):992-8 - PubMed
- Hum Vaccin Immunother. 2016 Mar 3;12(3):785-93 - PubMed
- PLoS One. 2015 Dec 16;10(12):e0145568 - PubMed
- PLoS Med. 2017 Apr 18;14(4):e1002282 - PubMed
- Cochrane Database Syst Rev. 2019 Mar 25;3:CD008521 - PubMed
- Pediatr Infect Dis J. 2007 Dec;26(12):1099-104 - PubMed
- J Formos Med Assoc. 2009 Apr;108(4):280-5 - PubMed
- J Infect. 2016 Jul 5;72 Suppl:S13-22 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A24-9 - PubMed
- Sci Rep. 2015 Oct 06;5:14658 - PubMed
- N Engl J Med. 2017 Jul 20;377(3):302 - PubMed
- Viral Immunol. 2007 Summer;20(2):300-11 - PubMed
- BMC Med. 2018 Jan 29;16(1):10 - PubMed
- J Infect Dis. 2016 Jun 1;213(11):1678-85 - PubMed
- Vaccine. 2021 Mar 5;39(10):1534-1543 - PubMed
- Pediatrics. 2007 Aug;120(2):e253-61 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A101-5 - PubMed
- Cochrane Database Syst Rev. 2004;(1):CD002848 - PubMed
- Lancet Glob Health. 2018 Sep;6(9):e1036-e1044 - PubMed
- Pediatr Infect Dis J. 2012 May;31(5):509-13 - PubMed
- J Pediatr (Rio J). 2007 May-Jun;83(3):217-24 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A61-70 - PubMed
- Hum Vaccin Immunother. 2017 Aug 3;13(8):1916-1920 - PubMed
- Pediatrics. 2010 Dec;126(6):e1499-506 - PubMed
- J Infect Dis. 2017 Mar 15;215(6):928-932 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A44-51 - PubMed
- Vaccine. 2009 Feb 25;27(9):1333-9 - PubMed
- Vaccine. 2017 Jun 16;35(28):3575-3581 - PubMed
- Pediatr Infect Dis J. 2005 Jun;24(6):481-8 - PubMed
- Pediatr Infect Dis J. 2010 Mar;29(3):263-5 - PubMed
- J Infect Dis. 2020 May 04;: - PubMed
- Vaccine. 2019 Jul 18;37(31):4407-4413 - PubMed
- Wkly Epidemiol Rec. 2012 May 25;87(21):201-16 - PubMed
- Pediatr Infect Dis J. 2008 Oct;27(10):874-80 - PubMed
- N Engl J Med. 2006 Jan 5;354(1):11-22 - PubMed
- Vaccine. 2015 Jun 9;33(25):2939-43 - PubMed
- Vaccine. 1998 Feb;16(4):381-7 - PubMed
- Vaccine. 2009 Oct 9;27(43):5936-41 - PubMed
- Hum Vaccin Immunother. 2014;10(1):19-24 - PubMed
- Vaccine. 2006 May 1;24(18):3782-3 - PubMed
- Hum Vaccin Immunother. 2017 May 4;13(5):1136-1140 - PubMed
- Vaccine. 2018 Jun 14;36(25):3674-3680 - PubMed
- J Infect Dis. 2018 Jul 13;218(4):606-613 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A86-93 - PubMed
- Clin Infect Dis. 2018 Jul 2;67(2):186-192 - PubMed
- J Infect Dis. 2016 Jun 1;213(11):1673-5 - PubMed
- Pediatr Infect Dis J. 2015 Jun;34(6):635-43 - PubMed
- N Engl J Med. 2018 Apr 19;378(16):1521-1528 - PubMed
- Hum Vaccin Immunother. 2012 Jun;8(6):806-12 - PubMed
- J Infect Dis. 2016 Jun 1;213(11):1686-93 - PubMed
- Vaccine. 2018 Jan 4;36(2):273-279 - PubMed
- Front Immunol. 2018 Jan 19;8:2002 - PubMed
- Lancet Infect Dis. 2020 Jul;20(7):851-863 - PubMed
- MMWR Recomm Rep. 1999 Mar 19;48(RR-2):1-20 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A52-60 - PubMed
- J Infect Dis. 2005 Sep 1;192 Suppl 1:S36-43 - PubMed
- Vaccine. 2006 May 29;24(22):4821-9 - PubMed
- JAMA. 2012 Feb 8;307(6):598-604 - PubMed
- Vaccine. 2018 Jan 4;36(2):264-272 - PubMed
- N Engl J Med. 2014 Feb 6;370(6):513-9 - PubMed
- N Engl J Med. 2011 Dec 1;365(22):2139 - PubMed
- Vaccine. 2018 Dec 18;36(52):7943-7949 - PubMed
- Hum Vaccin Immunother. 2017 Aug 3;13(8):1908-1915 - PubMed
- Pediatr Infect Dis J. 2012 May;31(5):487-93 - PubMed
- Pediatr Infect Dis J. 2005 Sep;24(9):807-16 - PubMed
- J Infect Dis. 2018 Mar 5;217(6):861-868 - PubMed
- N Engl J Med. 2017 Mar 23;376(12):1121-1130 - PubMed
- Hum Vaccin Immunother. 2013 Aug;9(8):1626-33 - PubMed
- Vaccine. 2020 Feb 24;38(9):2190-2197 - PubMed
- PLoS Med. 2012;9(10):e1001330 - PubMed
- Vaccine. 2019 Mar 22;37(13):1836-1843 - PubMed
- Vaccine. 2015 Feb 18;33(8):1017-20 - PubMed
- Vaccine. 2006 Jul 26;24(31-32):5817-23 - PubMed
- Vaccine. 2020 Oct 27;38(46):7393-7400 - PubMed
- N Engl J Med. 2001 Feb 22;344(8):564-72 - PubMed
- Pediatr Infect Dis J. 2019 May;38(5):539-541 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A122-30 - PubMed
- J Infect Dis. 2020 Oct 13;222(10):1731-1739 - PubMed
- Pediatr Infect Dis J. 2003 Oct;22(10):914-20 - PubMed
- Pediatr Infect Dis J. 2010 Oct;29(10):957-63 - PubMed
- BMC Infect Dis. 2017 Aug 15;17(1):569 - PubMed
- Pediatr Infect Dis J. 2007 Mar;26(3):221-7 - PubMed
- PLoS Med. 2011 Apr;8(4):e1001024 - PubMed
- Vaccine. 2011 Nov 28;29(51):9508-13 - PubMed
- Vaccine. 2004 Jul 29;22(21-22):2836-42 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A79-85 - PubMed
- BMC Biol. 2010 Oct 04;8:129 - PubMed
- Pediatrics. 2016 Feb;137(2):e20152603 - PubMed
- Trials. 2014 Jun 28;15:256 - PubMed
- J Infect Dis. 2004 Jun 15;189(12):2290-3 - PubMed
- Pediatrics. 2007 Jan;119(1):11-8 - PubMed
- Am J Trop Med Hyg. 2015 Apr;92(4):744-51 - PubMed
- Hum Vaccin. 2011 Jan 1;7(1):74-80 - PubMed
- Int J Infect Dis. 2007 Nov;11 Suppl 2:S29-35 - PubMed
- Clin Infect Dis. 2006 Aug 1;43(3):312-4 - PubMed
- Future Microbiol. 2018 Jan;13:97-118 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A71-8 - PubMed
- Cochrane Database Syst Rev. 2012 Feb 15;(2):CD008521 - PubMed
- Hum Vaccin Immunother. 2014;10(6):1436-48 - PubMed
- Vaccine. 2016 Jul 12;34(32):3684-9 - PubMed
- Hum Vaccin Immunother. 2019;15(4):800-808 - PubMed
- N Engl J Med. 2014 Feb 6;370(6):503-12 - PubMed
- Vaccine. 2009 Dec 11;28(2):345-51 - PubMed
- N Engl J Med. 2020 Nov 12;383(20):1932-1940 - PubMed
- J Infect Dis. 1996 Sep;174 Suppl 1:S73-80 - PubMed
- Lancet Infect Dis. 2019 Jul;19(7):717-727 - PubMed
- BMC Infect Dis. 2012 Sep 13;12:213 - PubMed
- J Infect Dis. 2006 Dec 15;194(12):1729-36 - PubMed
- J Infect Dis. 2021 Oct 13;224(7):1147-1151 - PubMed
- Pediatr Infect Dis J. 2017 Jan;36(1):72-78 - PubMed
- Wkly Epidemiol Rec. 2009 Jun 5;84(23):220-36 - PubMed
- Hum Vaccin Immunother. 2020 Mar 3;16(3):693-702 - PubMed
- Vaccine. 2011 Mar 3;29(11):2079-84 - PubMed
- Int J Infect Dis. 2007 Nov;11 Suppl 2:S36-42 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A114-21 - PubMed
- Lancet. 1999 Jul 24;354(9175):287-90 - PubMed
- Vaccine. 2011 Apr 5;29(16):3061-6 - PubMed
- Vaccine. 2013 Apr 26;31(18):2253-9 - PubMed
- Clin Infect Dis. 2016 Jan 15;62(2):150-6 - PubMed
- Vaccine. 2014 Aug 11;32 Suppl 1:A129-33 - PubMed
- Lancet. 2010 Aug 21;376(9741):606-14 - PubMed
- Pediatr Infect Dis J. 2004 Oct;23(10 Suppl):S179-82 - PubMed
- Vaccine. 2011 Aug 26;29(37):6335-41 - PubMed
- Lancet Infect Dis. 2017 Aug;17(8):843-853 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A94-100 - PubMed
- Pediatr Infect Dis J. 2011 Jun;30(6):e103-8 - PubMed
- Hum Vaccin Immunother. 2016 Oct 2;12(10):2580-2589 - PubMed
- Clin Infect Dis. 2017 Sep 1;65(5):840-850 - PubMed
- Lancet Glob Health. 2020 Sep;8(9):e1195-e1202 - PubMed
- J Pediatr. 2004 Feb;144(2):184-90 - PubMed
- J Infect Dis. 2018 Apr 11;217(9):1399-1407 - PubMed
- BMC Public Health. 2011 Apr 13;11 Suppl 3:S16 - PubMed
- Vaccine. 2017 Oct 27;35(45):6228-6237 - PubMed
- Pediatr Infect Dis J. 2008 Feb;27(2):177-8 - PubMed
- Pediatr Infect Dis J. 2013 Apr;32(4):e134-47 - PubMed
- Pediatr Infect Dis J. 2016 Oct;35(10):1137-9 - PubMed
- N Engl J Med. 2011 Jul 28;365(4):337-46 - PubMed
- J Infect Dis. 2005 Sep 1;192 Suppl 1:S6-S16 - PubMed
- Vaccine. 2017 Oct 13;35(43):5897-5904 - PubMed
- Vaccine. 2012 Jun 22;30(30):4552-7 - PubMed
- Vaccine. 2012 Apr 27;30 Suppl 1:A106-13 - PubMed
- J Infect Dis. 2017 Mar 1;215(5):786-789 - PubMed
- Clin Infect Dis. 2016 Sep 1;63(5):634-41 - PubMed
- Clin Infect Dis. 2013 Nov;57(10):1427-34 - PubMed
- Lancet Infect Dis. 2012 Feb;12(2):136-41 - PubMed
- Vaccine. 2020 Dec 3;38(51):8161-8166 - PubMed
- Pediatr Infect Dis J. 2012 Feb;31(2):184-8 - PubMed
- Science. 2006 May 12;312(5775):851-2 - PubMed
- Vaccine. 2018 Sep 5;36(37):5519-5523 - PubMed
- J Pediatr Gastroenterol Nutr. 2013 Jun;56(6):635-40 - PubMed
- Indian Pediatr. 2015 Oct;52(10):906 - PubMed
- Vaccine. 2011 Mar 3;29(11):2029-36 - PubMed
- Mem Inst Oswaldo Cruz. 2012 Nov;107(7):846-53 - PubMed
- Clin Vaccine Immunol. 2011 May;18(5):878-84 - PubMed
- Pediatr Infect Dis J. 2011 Feb;30(2):125-30 - PubMed
- N Engl J Med. 2011 Jun 16;364(24):2283-92 - PubMed
- JAMA Netw Open. 2019 Oct 2;2(10):e1912458 - PubMed
- Vaccine. 2006 May 1;24(18):3780-1 - PubMed
- Hum Vaccin Immunother. 2014;10(1):11-8 - PubMed
- Vaccine. 2014 Aug 11;32 Suppl 1:A104-9 - PubMed
- Pediatr Infect Dis J. 2008 Jul;27(7):656-8 - PubMed
- Vaccine. 2019 Nov 20;37(49):7233-7239 - PubMed
- J Infect Dis. 2002 Nov 15;186(10):1487-9 - PubMed
- Vaccine. 2014 Aug 11;32 Suppl 1:A124-8 - PubMed
- N Engl J Med. 1996 Oct 3;335(14):1022-8 - PubMed
- Vaccine. 2010 Jul 19;28(32):5272-9 - PubMed
- J Pediatric Infect Dis Soc. 2018 Feb 19;7(1):82-85 - PubMed
- Clin Infect Dis. 2020 Apr 10;70(8):1606-1612 - PubMed
- BMJ. 2003 Sep 6;327(7414):557-60 - PubMed
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