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Madhavan A, Palappallil DS, Balakrishnapanicker J, et al. Immune response to hepatitis B vaccine: An evaluation. Perspect Clin Res. 2020;12(4):209-215doi: 10.4103/picr.PICR_119_19.
Madhavan, A., Palappallil, D. S., Balakrishnapanicker, J., & Asokan, A. (2021). Immune response to hepatitis B vaccine: An evaluation. Perspectives in clinical research, 12(4), 209-215. https://doi.org/10.4103/picr.PICR_119_19
Madhavan, Anitha, et al. "Immune response to hepatitis B vaccine: An evaluation." Perspectives in clinical research vol. 12,4 (2021): 209-215. doi: https://doi.org/10.4103/picr.PICR_119_19
Madhavan A, Palappallil DS, Balakrishnapanicker J, Asokan A. Immune response to hepatitis B vaccine: An evaluation. Perspect Clin Res. 2021 Oct-Dec;12(4):209-215. doi: 10.4103/picr.PICR_119_19. Epub 2020 May 07. PMID: 34760649; PMCID: PMC8525787.
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Perspect Clin Res. 2021 Oct-Dec;12(4):209-215. doi: 10.4103/picr.PICR_119_19. Epub 2020 May 07.

Immune response to hepatitis B vaccine: An evaluation.

Perspectives in clinical research

Anitha Madhavan, Dhanya Sasidharan Palappallil, Jayalakshmy Balakrishnapanicker, Anjana Asokan

Affiliations

  1. Department of Microbiology, Government TD Medical College, Alappuzha, Kerala, India.
  2. Department of Pharmacology, Government Medical College, Kottayam, Kerala, India.
  3. Department of Microbiology, Government Medical College, Idukki, Kerala, India.

PMID: 34760649 PMCID: PMC8525787 DOI: 10.4103/picr.PICR_119_19

Abstract

BACKGROUND: Hepatitis B virus infection is a major public health problem in India, and all health-care workers (HCWs) need to be immunized to prevent occupational exposure. This study was done to find the hepatitis B vaccination rates, immune response, and predictors of titer <10 mIU/ml among students and HCWs of a tertiary care institution in the state of Kerala.

MATERIALS AND METHODS: This was a cross-sectional study conducted in the Department of Microbiology, Government TD Medical College, Alappuzha, Kerala, India, for a period of 1½ years between January 1, 2016, and June 30, 2017. Vaccination rates were collected through a screening proforma. Of the 1321 participants who filled the screening proforma, 5 ml of blood was collected aseptically from 579 participants who were fully vaccinated (all the three doses of vaccine) and stored at -20°C until antibody to hepatitis B surface antigen (anti-HBs) assay was done using Microlisa (Biorad). Data were analyzed using SPSS for Windows, version 16.0. (SPSS Inc., Chicago, IL, USA) (trial version).

STATISTICAL ANALYSIS: Descriptive data were expressed using frequencies and percentages, and Chi-square test was applied to find the association between antibody titer <10 mIU/ml and independent variables.

RESULTS: Of the 1321 participants who filled up the screening proforma, the vaccination rate was 72.6%. Majority of the participants, i.e. 83.5% of doctors, 81.1% of nurses, 69.7% of students, and 21.4% of technicians, had taken all the three doses of hepatitis B vaccine. Of the fully vaccinated (

CONCLUSION: More than a quarter of the study population who were at high risk of exposure were unvaccinated or partially vaccinated. Even after taking the full course of hepatitis B vaccine, 12.3% had titer <10 mIU/ml. Nonprotective titer was found to be associated with age >35 years, last dose taken >10 years ago, no boosters/revaccination, and BMI ≥25.

Copyright: © 2020 Perspectives in Clinical Research.

Keywords: Antibody titer; health-care workers; hepatitis B; immune response; occupational exposure; vaccine

Conflict of interest statement

There are no conflicts of interest.

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