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Vega-García S, Saucedo-García R, Basurto-Acevedo ML, et al. Polimorfismos del receptor de estrógenos alfa y su asociación con la densidad mamaria. Alpha estrogen receptor polymorphisms and their association with breast density. Rev Med Inst Mex Seguro Soc. 2020;58:S13-S20doi: 10.24875/RMIMSS.M20000111.
Vega-García, S., Saucedo-García, R., Basurto-Acevedo, M. L., Vargas-Gutiérrez, C., Galván-Duarte, R. E., Reyes-Maldonado, E., Aguilar-Gallegos, U. I., Avelar-Garnica, F., & Galván-Plata, M. E. (2020). Polimorfismos del receptor de estrógenos alfa y su asociación con la densidad mamaria. Alpha estrogen receptor polymorphisms and their association with breast density. Revista medica del Instituto Mexicano del Seguro Social, 58S13-S20. https://doi.org/10.24875/RMIMSS.M20000111
Vega-García, Sara, et al. "Polimorfismos del receptor de estrógenos alfa y su asociación con la densidad mamaria." Alpha estrogen receptor polymorphisms and their association with breast density. Revista medica del Instituto Mexicano del Seguro Social vol. 58 (2020): S13-S20. doi: https://doi.org/10.24875/RMIMSS.M20000111
Vega-García S, Saucedo-García R, Basurto-Acevedo ML, Vargas-Gutiérrez C, Galván-Duarte RE, Reyes-Maldonado E, Aguilar-Gallegos UI, Avelar-Garnica F, Galván-Plata ME. Polimorfismos del receptor de estrógenos alfa y su asociación con la densidad mamaria. Alpha estrogen receptor polymorphisms and their association with breast density. Rev Med Inst Mex Seguro Soc. 2020 Apr 27;58:S13-S20. doi: 10.24875/RMIMSS.M20000111. Spanish. PMID: 34695312.
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Rev Med Inst Mex Seguro Soc. 2020 Apr 27;58:S13-S20. doi: 10.24875/RMIMSS.M20000111.

Alpha estrogen receptor polymorphisms and their association with breast density.

Revista medica del Instituto Mexicano del Seguro Social

[Article in Spanish]
Sara Vega-García, Renata Saucedo-García, María de Lourdes Basurto-Acevedo, Columba Vargas-Gutiérrez, Rosa Elva Galván-Duarte, Elba Reyes-Maldonado, Uriban Israel Aguilar-Gallegos, Francisco Avelar-Garnica, María Eugenia Galván-Plata

Affiliations

  1. Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Unidad de Investigación Médica en Enfermedades Endocrinas.
  2. Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Radiología e Imagen.
  3. Instituto Politécnico Nacional, Campus Zacatenco, Escuela Nacional de Ciencias Biológicas, Departamento de Morfología.
  4. Instituto Mexicano del Seguro Social, Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", Servicio de Oncología Mamaria.
  5. Instituto Mexicano del Seguro Social, Coordinación de Investigación en Salud, División de Desarrollo de la Investigación, Investigadora Jubilada. Ciudad de México, México.

PMID: 34695312 DOI: 10.24875/RMIMSS.M20000111

Abstract

BACKGROUND: In the development of breast cancer (BC), estrogen exposure and the increase in breast density (BD) are two determinant factors for BC risk.

OBJECTIVE: To identify the relationship between the XbaI and PvuII polymorphisms in the estrogen receptor (ER-alpha) with BD.

MATERIAL AND METHODS: Cross-sectional study which included 225 women, aged 40-65 years, without evident cancer data, who underwent routine mammography for early BC diagnosis in a radiology department. Two groups were formed: women with increased and with normal BD. Participants were genotyped for the XbaI and PvuII polymorphisms.

RESULTS: 19.1% had normal weight, 37.7% overweight, and 43.2% were obese women. In relation to high-risk patterns, 105 women had increased BD and 120 had normal BD (53.3%). The frequency of women with increased BD was also lower in postmenopausal women. Regarding the type of BD, there was no statistically significant difference between frequencies of PvuII and XbaI genotypes. Logistic regression showed that only age and body mass index (BMI) were associated with BD.

CONCLUSION: PvuII and XbaI ER-alpha genotypes were similar among women with dense and non-dense breasts; differently, other factors were associated with BD (age, BMI and menopausal status). Therefore, emphasis should be placed on clinical practice in the relationship between BMI and BD.

Copyright: © 2020 Revista Medica del Instituto Mexicano del Seguro Social.

Keywords: Breast Density; Menopause; Obesity; Receptors, Estrogen

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