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Boch K, Langan EA, Kridin K, et al. Lichen Planus. Front Med (Lausanne). 2021;8:737813doi: 10.3389/fmed.2021.737813.
Boch, K., Langan, E. A., Kridin, K., Zillikens, D., Ludwig, R. J., & Bieber, K. (2021). Lichen Planus. Frontiers in medicine, 8737813. https://doi.org/10.3389/fmed.2021.737813
Boch, Katharina, et al. "Lichen Planus." Frontiers in medicine vol. 8 (2021): 737813. doi: https://doi.org/10.3389/fmed.2021.737813
Boch K, Langan EA, Kridin K, Zillikens D, Ludwig RJ, Bieber K. Lichen Planus. Front Med (Lausanne). 2021 Nov 01;8:737813. doi: 10.3389/fmed.2021.737813. eCollection 2021. PMID: 34790675; PMCID: PMC8591129.
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Front Med (Lausanne). 2021 Nov 01;8:737813. doi: 10.3389/fmed.2021.737813. eCollection 2021.

Lichen Planus.

Frontiers in medicine

Katharina Boch, Ewan A Langan, Khalaf Kridin, Detlef Zillikens, Ralf J Ludwig, Katja Bieber

Affiliations

  1. Department of Dermatology, University of Lübeck, Lübeck, Germany.
  2. Dermatological Sciences, University of Manchester, Manchester, United Kingdom.
  3. Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
  4. Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

PMID: 34790675 PMCID: PMC8591129 DOI: 10.3389/fmed.2021.737813

Abstract

Lichen planus (LP) is a T cell-mediated disease affecting the stratified squamous epithelia of the skin and/or mucus membrane. Histologically, the disease is characterized by a lichenoid inflammatory infiltrate and vacuolar degeneration of the basal layer of the epidermis. LP has three major subtypes: Cutaneous, mucosal and appendageal LP. Rarely, it may affect the nails in the absence of skin and/or mucosal changes. LP may also be induced by several drugs, typically anti-hypertensive medication or be associated with infections, particularly viral hepatitis. The diagnosis is based on the clinical presentation and characteristic histological findings. Although the disease is often self-limiting, the intractable pruritus and painful mucosal erosions result in significant morbidity. The current first-line treatment are topical and/or systemic corticosteroids. In addition, immunosuppressants may be used as corticosteroid-sparing agents. These, however are often not sufficient to control disease. Janus kinase inhibitors and biologics (anti-IL-12/23, anti-IL17) have emerged as novel future treatment options. Thus, one may expect a dramatic change of the treatment landscape of LP in the near future.

Copyright © 2021 Boch, Langan, Kridin, Zillikens, Ludwig and Bieber.

Keywords: T-cell mediated; inflammation; lichen planus; skin disease; treatment

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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