Display options
Cite
Papadopoulos GE, Evaggelou TI, Moulias EK, et al. Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome. J Cardiovasc Dev Dis. 2021;8(11)doi: 10.3390/jcdd8110152.
Papadopoulos, G. E., Evaggelou, T. I., Moulias, E. K., Tsonis, O., Zekios, K. C., Nikas, D. N., Tzimas, P., Paschopoulos, M., & Kolettis, T. M. (2021). Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome. Journal of cardiovascular development and disease, 8(11), . https://doi.org/10.3390/jcdd8110152
Papadopoulos, Georgios E, et al. "Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome." Journal of cardiovascular development and disease vol. 8,11 (2021). doi: https://doi.org/10.3390/jcdd8110152
Papadopoulos GE, Evaggelou TI, Moulias EK, Tsonis O, Zekios KC, Nikas DN, Tzimas P, Paschopoulos M, Kolettis TM. Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome. J Cardiovasc Dev Dis. 2021 Nov 07;8(11). doi: 10.3390/jcdd8110152. PMID: 34821705; PMCID: PMC8620927.
Copy Download .nbib Format: NLM
Share it on

J Cardiovasc Dev Dis. 2021 Nov 07;8(11). doi: 10.3390/jcdd8110152.

Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome.

Journal of cardiovascular development and disease

Georgios E Papadopoulos, Theoxaris I Evaggelou, Errikos K Moulias, Orestis Tsonis, Konstantinos C Zekios, Dimitrios N Nikas, Petros Tzimas, Minas Paschopoulos, Theofilos M Kolettis

Affiliations

  1. 1st Cardiology Department, University Hospital of Ioannina, 45500 Ioannina, Greece.
  2. Department of Obstetrics & Gynecology, University Hospital of Ioannina, 45500 Ioannina, Greece.
  3. Anesthesiology Department, University Hospital of Ioannina, 45500 Ioannina, Greece.

PMID: 34821705 PMCID: PMC8620927 DOI: 10.3390/jcdd8110152

Abstract

Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of delivery. Here, we explored the hypothesis that the different management of cesarean and vaginal delivery may elicit diverse responses affecting both autonomic arms. For this aim, continuous electrocardiographic recording was performed in 20 women during labor, and non-invasive indices of sympathetic and vagal activity were compared between the two modes of delivery. We report sympathetic prevalence during cesarean delivery, caused by marked vagal withdrawal, whereas autonomic activity was rather stable during vaginal delivery. These differences may be attributed to the effects of anesthesia during cesarean delivery, along with the protective effects of oxytocin administration during vaginal delivery. Our results provide further insights on autonomic responses during labor that may prove useful in the prevention of complications, such as takotsubo syndrome.

Keywords: cesarean delivery; sympathetic responses; vagal responses; vaginal delivery

References

  1. Br J Anaesth. 1997 Jun;78(6):642-51 - PubMed
  2. J Matern Fetal Neonatal Med. 2021 Oct 15;:1-6 - PubMed
  3. Eur Heart J. 1996 Mar;17(3):354-81 - PubMed
  4. Birth. 2018 Mar;45(1):19-27 - PubMed
  5. Am J Cardiol. 2016 Jan 15;117(2):206-13 - PubMed
  6. Anesth Analg. 1988 Sep;67(9):906-7 - PubMed
  7. Biol Psychiatry. 2003 Dec 15;54(12):1389-98 - PubMed
  8. Anesthesiology. 1992 May;76(5):725-33 - PubMed
  9. Pacing Clin Electrophysiol. 2010 Nov;33(11):1407-17 - PubMed
  10. QJM. 2007 Jun;100(6):335-43 - PubMed
  11. Circulation. 2017 Jun 13;135(24):2426-2441 - PubMed
  12. Am J Physiol. 1999 Dec;277(6):H2233-9 - PubMed
  13. Gynecol Obstet Invest. 2012;74(1):35-40 - PubMed
  14. Obstet Med. 2009 Mar;2(1):6-10 - PubMed
  15. J Am Coll Cardiol. 2018 Apr 24;71(16):1838-1839 - PubMed
  16. Midwifery. 2007 Sep;23(3):235-47 - PubMed
  17. Life Sci. 2006 Jan 18;78(8):882-7 - PubMed
  18. Br J Anaesth. 2003 Jun;90(6):766-73 - PubMed
  19. BMC Pregnancy Childbirth. 2019 Mar 12;19(1):89 - PubMed
  20. Am J Obstet Gynecol. 1977 Sep 1;129(1):5-8 - PubMed
  21. Front Psychol. 2020 Aug 05;11:1792 - PubMed
  22. Obstet Gynecol. 2011 Jan;117(1):69-74 - PubMed
  23. Circulation. 1994 Jan;89(1):164-8 - PubMed
  24. Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:1929-32 - PubMed
  25. Eur Heart J. 2016 Oct 01;37(37):2823-2829 - PubMed
  26. Front Public Health. 2017 Sep 28;5:258 - PubMed
  27. J Obstet Gynaecol Res. 2014 Jun;40(6):1534-9 - PubMed
  28. J Perinat Med. 1985;13(1):3-13 - PubMed
  29. Cases J. 2008 Oct 08;1(1):227 - PubMed
  30. Curr Clin Pharmacol. 2011 Feb;6(1):1-11 - PubMed
  31. Anat Rec. 2000 Aug 1;259(4):353-82 - PubMed
  32. Cardiovasc Res. 2012 Sep 1;95(4):487-94 - PubMed
  33. Front Physiol. 2013 Feb 20;4:26 - PubMed
  34. Pharmacol Rev. 2020 Oct;72(4):829-861 - PubMed
  35. Biol Psychol. 2011 Mar;86(3):174-80 - PubMed
  36. Anesthesiology. 2003 Jan;98(1):34-40 - PubMed
  37. Am J Obstet Gynecol. 1982 Sep 15;144(2):149-53 - PubMed
  38. Arch Gynecol Obstet. 2011 Apr;283(4):687-94 - PubMed
  39. Front Psychol. 2014 Sep 30;5:1040 - PubMed

Publication Types