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Dussan Molinos L, Huchzermeyer C, Lämmer R, et al. Blue-Yellow VEP with Projector-Stimulation in Glaucoma. Graefes Arch Clin Exp Ophthalmol. 2021;doi: 10.1007/s00417-021-05473-w.
Dussan Molinos, L., Huchzermeyer, C., Lämmer, R., Kremers, J., & Horn, F. K. (2021). Blue-Yellow VEP with Projector-Stimulation in Glaucoma. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, . https://doi.org/10.1007/s00417-021-05473-w
Dussan Molinos, Laura, et al. "Blue-Yellow VEP with Projector-Stimulation in Glaucoma." Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie vol. (2021). doi: https://doi.org/10.1007/s00417-021-05473-w
Dussan Molinos L, Huchzermeyer C, Lämmer R, Kremers J, Horn FK. Blue-Yellow VEP with Projector-Stimulation in Glaucoma. Graefes Arch Clin Exp Ophthalmol. 2021 Nov 25; doi: 10.1007/s00417-021-05473-w. Epub 2021 Nov 25. PMID: 34821990.
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Graefes Arch Clin Exp Ophthalmol. 2021 Nov 25; doi: 10.1007/s00417-021-05473-w. Epub 2021 Nov 25.

Blue-Yellow VEP with Projector-Stimulation in Glaucoma.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Laura Dussan Molinos, Cord Huchzermeyer, Robert Lämmer, Jan Kremers, Folkert K Horn

Affiliations

  1. Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.
  2. Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany. [email protected].

PMID: 34821990 DOI: 10.1007/s00417-021-05473-w

Abstract

BACKGROUND AND AIM: In the past, increased latencies of the blue-on-yellow pattern visually evoked potentials (BY-VEP), which predominantly originate in the koniocellular pathway, have proven to be a sensitive biomarker for early glaucoma. However, a complex experimental setup based on an optical bench was necessary to obtain these measurements because computer screens lack sufficient temporal, spatial, spectral, and luminance resolution. Here, we evaluated the diagnostic value of a novel setup based on a commercially available video projector.

METHODS: BY-VEPs were recorded in 126 participants (42 healthy control participants, 12 patients with ocular hypertension, 17 with "preperimetric" glaucoma, and 55 with perimetric glaucoma). Stimuli were created with a video projector (DLP technology) by rear projection of a blue checkerboard pattern (460 nm) for 200 ms (onset) superimposed on a bright yellow background (574 nm), followed by an offset interval where only the background was active. Thus, predominantly S-cones were stimulated while L- and M-cone responses were suppressed by light adaptation. Times of stimulus onset to VEP onset-trough (N-peak time) and offset-peak (P-peak time) were analyzed after age-correction based on linear regression in the normal participants.

RESULTS: The resulting BY-VEPs were quite similar to those obtained in the past with the optical bench: pattern-onset generated a negative deflection of the VEP, whereas the offset-response was dominated by a positive component. N-peak times were significantly increased in glaucoma patients (preperimetric 136.1 ± 10 ms, p < 0.05; perimetric 153.1 ± 17.8 ms, p < 0.001) compared with normal participants (123.6 ± 7.7 ms). Furthermore, they were significantly correlated with disease severity as determined by visual field losses retinal nerve fiber thinning (Spearman R = -0.7, p < 0.001).

CONCLUSIONS: Video projectors can be used to create optical stimuli with high temporal and spatial resolution, thus potentially enabling sophisticated electrophysiological measurements in clinical practice. BY-VEPs based on such a projector had a high diagnostic value for detection of early glaucoma. Registration of study Registration site: www.clinicaltrials.gov Trial registration number: NCT00494923.

© 2021. The Author(s).

Keywords: Blue–yellow VEP; Glaucoma; Onset–offset VEP; Projector-stimulation

References

  1. Greenstein VC, Seliger S, Zemon V, Ritch R (1998) Visual evoked potential assessment of the effects of glaucoma on visual subsystems. Vision Res 38:1901–1911 - PubMed
  2. Hu CX, Zangalli C, Hsieh M, Gupta L, Williams AL, Richman J, Spaeth GL (2014) What do patients with glaucoma see? Visual symptoms reported by patients with glaucoma. Am J Med Sci 348:403–409. https://doi.org/10.1097/maj.0000000000000319 - PubMed
  3. Horn FK, Jonas JB, Budde WM, Jünemann AM, Mardin CY, Korth M (2002) Monitoring glaucoma progression with visual evoked potentials of the blue-sensitive pathway. Invest Ophthalmol Vis Sci 43:1828–1834 - PubMed
  4. Anderson RS (2006) The psychophysics of glaucoma: improving the structure/function relationship. Elsevier Ltd 25:79–97. https://doi.org/10.1016/j.preteyeres.2005.06.001 - PubMed
  5. Tai TYT (2018) Visual evoked potentials and glaucoma. Asia Pac J Ophthalmol (Phila) 7:352–355. https://doi.org/10.22608/APO.2017532 - PubMed
  6. Parisi V, Miglior S, Manni G, Centofanti M, Bucci MG (2006) Clinical ability of pattern electroretinograms and visual evoked potentials in detecting visual dysfunction in ocular hypertension and glaucoma. Ophthalmology 113:216–228. https://doi.org/10.1016/j.ophtha.2005.10.044 - PubMed
  7. Kothari R, Bokariya P, Singh S, Singh R (2016) A comprehensive review on methodologies employed for visual evoked potentials. Scientifica (Cairo) 2016:9852194. https://doi.org/10.1155/2016/9852194 - PubMed
  8. Hohberger B, Kremers J, Horn FK (2019) Steady-state visually evoked potentials elicited by multifrequency pattern-reversal stimulation. Transl Vis Sci Technol 8:24. https://doi.org/10.1167/tvst.8.1.24 - PubMed
  9. Arakawa K, Tobimatsu S, Tomoda H, Kira J, Kato M (1999) The effect of spatial frequency on chromatic and achromatic steady-state visual evoked potentials. Clin Neurophysiol 110(11):1959–1964.  https://doi.org/10.1016/s1388-2457(99)00139-x - PubMed
  10. Robson AG, Kulikowski JJ (2012) Objective assessment of chromatic and achromatic pattern adaptation reveals the temporal response properties of different visual pathways. Vis Neurosci 29:301–313. https://doi.org/10.1017/s0952523812000351 - PubMed
  11. Accornero N, Gregori B, Pro S, Scappini G, La Riccia M (2008) Chromatic modulation of luminance visual evoked potential latencies in healthy subjects and patients with mild vision disorders. Clin Neurophysiol 119:1683–1688. https://doi.org/10.1016/j.clinph.2008.03.011 - PubMed
  12. Korth M, Nguyen NX, Junemann A, Martus P, Jonas JB (1994) VEP test of the blue-sensitive pathway in glaucoma. Invest Ophthalmol Vis Sci 35:2599–2610 - PubMed
  13. Horn FK, Bergua A, Junemann A, Korth M (2000) Visual evoked potentials under luminance contrast and color contrast stimulation in glaucoma diagnosis. J Glaucoma 9:428–437 - PubMed
  14. Kremers J, Stepien MW, Scholl HPN, Saito C (2003) Cone selective adaptation influences L- and M-cone driven signals in electroretinography and psychophysics. J Vis 3:146–160 - PubMed
  15. Kremers J, McKeefry DJ, Murray IJ, Parry NRA (2020) Developments in non-invasive visual electrophysiology. Vision Res 174:50–56. https://doi.org/10.1016/j.visres.2020.05.003 - PubMed
  16. Horn FK, Michelson G, Sehnitzler E, Mardin CY, Korth M, Junemann AG (2006) Visual evoked potentials of the blue-sensitive pathway under cold provocation in normals and glaucomas. J Glaucoma 15:17–22. https://doi.org/10.1097/01.ijg.0000196656.23578.1b - PubMed
  17. Packer O, Diller LC, Verweij J, Lee BB, Williams DR, Dacey DM, Pokorny J, Brainard DH (2001) Characterization and use of a digital light projector for vision research. Vision Res 41:427–439 - PubMed
  18. Gause A (2014) Projektionsfolien. Produktion partner 7-8: 46-51 - PubMed
  19. Robson AG, Nilsson J, Li S, Jalali S, Fulton AB, Tormene AP, Holder GE, Brodie SE (2018) ISCEV guide to visual electrodiagnostic procedures. Doc Ophthalmol 136:1–26. https://doi.org/10.1007/s10633-017-9621-y - PubMed
  20. Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Mizota A, Tormene AP (2016) ISCEV standard for clinical visual evoked potentials: (2016 update). Doc Ophthalmol 133:1–9. https://doi.org/10.1007/s10633-016-9553-y - PubMed
  21. Lauterwald F, Neumann CP, Lenz R, Jünemann AG, Mardin CY, Meyer-Wegener K, Horn FK (2012) The Erlangen Glaucoma Registry: a scientific database for longitudinal analysis of glaucoma. Technical reports/Dep Informatik CS-2011, 2:1–9 - PubMed
  22. Jonas JB, Gusek GC, Naumann GO (1988) Optic disc morphometry in chronic primary open-angle glaucoma. I. Morphometric intrapapillary characteristics. Graefes Arch Clin Exp Ophthalmol 226:522–530 - PubMed
  23. Horn FK, Mardin CY, Laemmer R, Baleanu D, Juenemann AM, Kruse FE, Tornow RP (2009) Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with polarimetry and spectral domain OCT. Invest Ophthalmol Vis Sci 50:1971–1977. https://doi.org/10.1167/iovs.08-2405 - PubMed
  24. Porciatti V, Burr DC, Morrone MC, Fiorentini A (1992) The effects of aging on the pattern electroretinogram and visual evoked potential in humans. Vision Res 32:1199–1209. https://doi.org/10.1016/0042-6989(92)90214-4 - PubMed
  25. Fuest M, Kieckhoefel J, Mazinani B, Kuerten D, Koutsonas A, Koch E, Walter P, Plange N (2015) Blue-yellow and standard pattern visual evoked potentials in phakic and pseudophakic glaucoma patients and controls. Graefes Arch Clin Exp Ophthalmol 253:2255–2261. https://doi.org/10.1007/s00417-015-3152-6 - PubMed
  26. Klistorner A, Graham SL, Martins A, Grigg JR, Arvind H, Kumar RS, James AC, Billson FA (2007) Multifocal blue-on-yellow visual evoked potentials in early glaucoma. Ophthalmology 114:1613–1621. https://doi.org/10.1016/j.ophtha.2006.11.037 - PubMed
  27. Porciatti V, Sartucci F (1999) Normative data for onset VEPs to red-green and blue-yellow chromatic contrast. Clin Neurophysiol 110(4):772–781. https://doi.org/10.1016/s1388-2457(99)00007-3 - PubMed
  28. Korth M, Horn FK, Storck B, Jonas J (1989) The pattern-evoked electroretinogram (PERG) Age-related alterations and changes in glaucoma. Graefes Arch Clin Exp Ophthalmol 227(2):123–130 - PubMed
  29. Rodarte C, Hood DC, Yang EB, Grippo T, Greenstein VC, Liebmann JM, Ritch R (2006) The effects of glaucoma on the latency of the multifocal visual evoked potential. Br J Ophthalmol 90:1132–1136. https://doi.org/10.1136/bjo.2006.095158 - PubMed
  30. Korth M, Nguyen NX (1997) The effect of stimulus size on human cortical potentials evoked by chromatic patterns. Vision Res 37: 649–657 S0042–6989(96)00189–7 [pii] - PubMed
  31. Accornero N, Gregori B, Galie E, Feo AD, Agnesi R (2000) A new color vep procedure discloses asymptomatic visual impairments in optic neuritis and glaucoma suspects. Acta Neurologica Scandinavica 102:258–263 - PubMed
  32. Martin PR, White AJ, Goodchild AK, Wilder HD, Sefton AE (1997) Evidence that blue-on cells are part of the third geniculocortical pathway in primates. Eur J Neurosci 9:1536–1541 - PubMed
  33. Fuest M, Plange N, Jamali S, Schwarzer H, Roessler G, Walter P, Mazinani B (2014) The effect of cataract surgery on blue-yellow and standard-pattern visual-evoked potentials. Graefes Arch Clin Exp Ophthalmol 252:1831–1837. https://doi.org/10.1007/s00417-014-2728-x - PubMed
  34. Fox M, Barber C, Perkins A, Keating D (2014) Comparison of cathode ray tube and liquid crystal display stimulators for use in multifocal VEP. Doc Ophthalmol 129:115–122. https://doi.org/10.1007/s10633-014-9451-0 - PubMed
  35. Matsumoto CS, Shinoda K, Matsumoto H, Funada H, Minoda H, Mizota A (2013) Liquid crystal display screens as stimulators for visually evoked potentials: flash effect due to delay in luminance changes. Doc Ophthalmol 127:103–112. https://doi.org/10.1007/s10633-013-9387-9 - PubMed
  36. Kaltwasser C, Horn FK, Kremers J, Juenemann A (2008) A comparison of the suitability of cathode ray tube (CRT) and liquid crystal display (LCD) monitors as visual stimulators in mfERG diagnostics. Doc Ophthalmol 118:179–189. https://doi.org/10.1007/s10633-008-9152-7 - PubMed
  37. Elze T (2010) Misspecifications of stimulus presentation durations in experimental psychology: a systematic review of the psychophysics literature. PLoS One 5:e12792. https://doi.org/10.1371/journal.pone.0012792 - PubMed
  38. Matsumoto CS, Shinoda K, Matsumoto H, Seki K, Nagasaka E, Iwata T, Mizota A (2014) What monitor can replace the cathode-ray tube for visual stimulation to elicit multifocal electroretinograms? J Vis 14:1–14. https://doi.org/10.1167/14.9.2 - PubMed
  39. Kwak Y, MacDonald L (2000) Characterisation of a desktop LCD projector. Elsevier Science BV 21:179–194 - PubMed
  40. Liu H, Bhushan B (2004) Nanotribological characterization of digital micromirror devices using an atomic force microscope. Ultramicroscopy 100:391–412. https://doi.org/10.1016/j.ultramic.2003.11.016 - PubMed
  41. Toadere F, Mastorakis N (2009) A comparison between a CRT and a LCD monitors colors rendering. https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.938.8429&rep=rep1&type=pdf - PubMed
  42. Bauer B (2015) A timely reminder about stimulus display times and other presentation parameters on CRTs and newer technologies. Can J Exp Psychol 69:264–273. https://doi.org/10.1037/cep0000043 - PubMed
  43. Brigell M, Chair MB, Barber C, Moskowitz A, Robson J (2003) Guidelines for calibration of stimulus and recording parameters used in clinical electrophysiology of vision. Doc Ophthalmol 107:185–193 - PubMed
  44. Garaizar P, Vadillo MA, López-de-Ipina D, Matute H (2014) Measuring software timing errors in the presentation of visual stimuli in cognitive neuroscience experiments. PLoS ONE 9:e85108. https://doi.org/10.1371/journal.pone.0085108 - PubMed

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