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Scaglione A, Panzarino C, Modica M, et al. Short- and long-term effects of a cardiac rehabilitation program in patients implanted with a left ventricular assist device. PLoS One. 2021;16(12):e0259927doi: 10.1371/journal.pone.0259927.
Scaglione, A., Panzarino, C., Modica, M., Tavanelli, M., Pezzano, A., Grati, P., Racca, V., Toccafondi, A., Bordoni, B., Verde, A., Cartella, I., & Castiglioni, P. (2021). Short- and long-term effects of a cardiac rehabilitation program in patients implanted with a left ventricular assist device. PloS one, 16(12), e0259927. https://doi.org/10.1371/journal.pone.0259927
Scaglione, Anna, et al. "Short- and long-term effects of a cardiac rehabilitation program in patients implanted with a left ventricular assist device." PloS one vol. 16,12 (2021): e0259927. doi: https://doi.org/10.1371/journal.pone.0259927
Scaglione A, Panzarino C, Modica M, Tavanelli M, Pezzano A, Grati P, Racca V, Toccafondi A, Bordoni B, Verde A, Cartella I, Castiglioni P. Short- and long-term effects of a cardiac rehabilitation program in patients implanted with a left ventricular assist device. PLoS One. 2021 Dec 01;16(12):e0259927. doi: 10.1371/journal.pone.0259927. eCollection 2021. PMID: 34851984; PMCID: PMC8635401.
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PLoS One. 2021 Dec 01;16(12):e0259927. doi: 10.1371/journal.pone.0259927. eCollection 2021.

Short- and long-term effects of a cardiac rehabilitation program in patients implanted with a left ventricular assist device.

PloS one

Anna Scaglione, Claudia Panzarino, Maddalena Modica, Monica Tavanelli, Antonio Pezzano, Paola Grati, Vittorio Racca, Anastasia Toccafondi, Bruno Bordoni, Alessandro Verde, Iside Cartella, Paolo Castiglioni

Affiliations

  1. Cardiology Rehabilitation Center, Santa Maria Nascente Institute, IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
  2. Heart Failure and Heart Transplant Program, CardioThoracic and Vascular Department, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  3. IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.

PMID: 34851984 PMCID: PMC8635401 DOI: 10.1371/journal.pone.0259927

Abstract

The efficacy of cardiac rehabilitation in heart-failure patients who received a left-ventricular assist device (LVAD) instead of heart transplantation (HTx) is still unclear. This study aims to evaluate whether cardiac rehabilitation is beneficial in LVAD as HTx patients in the short term and whether its effects in LVAD patients persist over time. Twenty-five LVAD patients were evaluated by functional and psychological tests at admission (T0) and discharge (T1) of a 4-week inpatient structured rehabilitation program, and follow-ups 3 (T2), 6 (T3), and 12 months (T4) after discharge. Twenty-five matched HTx patients were also studied from T0 to T1 to compare the improvements in the six-minute walk test (6MWT). The quality-of-life scores substantially improved in LVAD patients and the 6MWT showed the same functional recovery as in HTx patients from T0 to T1. After T1, numerous LVAD patients withdrew from the study. However, the 6MWT outcome increased further from T1 to T3, with a positive trend during the follow-ups. Hemoglobin and the ventilatory performance increased, and the psychological perception of heart-failure symptoms and pain further improved at T2. In conclusion, exercise-based rehabilitation programs provide similar beneficial effects in LVAD and HTx patients, without deterioration in LVAD patients up to 12 months after discharge.

Conflict of interest statement

The authors have declared that no competing interests exist.

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