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Brzozowska M, Mokrzycka N, Porebski G. Alpha-gal syndrome: the first report in Poland. Cent Eur J Immunol. 2021;46(3):398-400doi: 10.5114/ceji.2021.108766.
Brzozowska, M., Mokrzycka, N., & Porebski, G. (2021). Alpha-gal syndrome: the first report in Poland. Central-European journal of immunology, 46(3), 398-400. https://doi.org/10.5114/ceji.2021.108766
Brzozowska, Mirella, et al. "Alpha-gal syndrome: the first report in Poland." Central-European journal of immunology vol. 46,3 (2021): 398-400. doi: https://doi.org/10.5114/ceji.2021.108766
Brzozowska M, Mokrzycka N, Porebski G. Alpha-gal syndrome: the first report in Poland. Cent Eur J Immunol. 2021;46(3):398-400. doi: 10.5114/ceji.2021.108766. Epub 2021 Aug 28. PMID: 34764814; PMCID: PMC8574113.
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Cent Eur J Immunol. 2021;46(3):398-400. doi: 10.5114/ceji.2021.108766. Epub 2021 Aug 28.

Alpha-gal syndrome: the first report in Poland.

Central-European journal of immunology

Mirella Brzozowska, Natalia Mokrzycka, Grzegorz Porebski

Affiliations

  1. Department of Skin and Venereal Diseases, Clinical Hospital of the Pomeranian Medical University, Police, Poland.
  2. Jagiellonian University Medical College, Krakow, Poland.
  3. Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland.

PMID: 34764814 PMCID: PMC8574113 DOI: 10.5114/ceji.2021.108766

Abstract

Alpha-gal syndrome is an immunoglobulin E (IgE)-dependent allergy to galactose-α-1,3-galactose, resulting in a delayed anaphylactic reaction to red meat. The syndrome is causally linked to bites from ticks and associated with cross-reactivity to some drugs, e.g. cetuximab. Although cases of alpha-gal allergy have already been reported in a few European countries, to our best knowledge, no cases have been reported so far in Central-Eastern Europe. In the current report, we describe a case of alpha-gal syndrome diagnosed in Poland, to highlight the fact that it may occur in new geographic areas. Within three months, the described patient underwent five anaphylactic reactions with typical clinical manifestations. They developed a few hours after ingestion of red meat (pork, beef or mutton) and were preceded by tick bites. The level of specific IgE antibodies to alpha-gal reached 72.6 kAU/l, whereas the levels of specific IgE antibodies to other food allergens were within the reference range. As the onset of symptoms in this syndrome is usually delayed, numerous cases may be identified as idiopathic anaphylaxis, while early diagnosis is indispensable to avoid potentially life-threatening complications.

Copyright © 2021 Termedia.

Keywords: allergy; alpha-gal syndrome; anaphylaxis

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