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Liu X, Leopold DA, Yang Y, et al. Single-neuron firing cascades underlie global spontaneous brain events. Proc Natl Acad Sci U S A. 2021;118(47)doi: 10.1073/pnas.2105395118.
Liu, X., Leopold, D. A., Yang, Y., Skerritt, C., & Salokangas, M. (2021). Single-neuron firing cascades underlie global spontaneous brain events. Proceedings of the National Academy of Sciences of the United States of America, 118(47), . https://doi.org/10.1073/pnas.2105395118
Liu, Xiao, et al. "Single-neuron firing cascades underlie global spontaneous brain events." Proceedings of the National Academy of Sciences of the United States of America vol. 118,47 (2021). doi: https://doi.org/10.1073/pnas.2105395118
Liu X, Leopold DA, Yang Y, Skerritt C, Salokangas M. Single-neuron firing cascades underlie global spontaneous brain events. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47). doi: 10.1073/pnas.2105395118. PMID: 34795053; PMCID: PMC8617517.
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Proc Natl Acad Sci U S A. 2021 Nov 23;118(47). doi: 10.1073/pnas.2105395118.

Single-neuron firing cascades underlie global spontaneous brain events.

Proceedings of the National Academy of Sciences of the United States of America

Xiao Liu, David A Leopold, Yifan Yang, Skerritt, Salokangas

Affiliations

  1. Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802; [email protected].
  2. Institute for Computational and Data Sciences, The Pennsylvania State University, University Park, PA 16802.
  3. Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, and National Eye Institute, NIH, Bethesda, MD 20892.
  4. Section on Cognitive Neurophysiology and Imaging, Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892.
  5. Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.

PMID: 34795053 PMCID: PMC8617517 DOI: 10.1073/pnas.2105395118

Abstract

The resting brain consumes enormous energy and shows highly organized spontaneous activity. To investigate how this activity is manifest among single neurons, we analyzed spiking discharges of ∼10,000 isolated cells recorded from multiple cortical and subcortical regions of the mouse brain during immobile rest. We found that firing of a significant proportion (∼70%) of neurons conformed to a ubiquitous, temporally sequenced cascade of spiking that was synchronized with global events and elapsed over timescales of 5 to 10 s. Across the brain, two intermixed populations of neurons supported orthogonal cascades. The relative phases of these cascades determined, at each moment, the response magnitude evoked by an external visual stimulus. Furthermore, the spiking of individual neurons embedded in these cascades was time locked to physiological indicators of arousal, including local field potential power, pupil diameter, and hippocampal ripples. These findings demonstrate that the large-scale coordination of low-frequency spontaneous activity, which is commonly observed in brain imaging and linked to arousal, sensory processing, and memory, is underpinned by sequential, large-scale temporal cascades of neuronal spiking across the brain.

Keywords: global signal; hippocampal ripples; low-frequency resting-state activity; neuronal population dynamics; sequential activations

Conflict of interest statement

The authors declare no competing interest.

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