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Snarski P, Sukhanov S, Yoshida T, et al. Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice. Arterioscler Thromb Vasc Biol. 2021;ATVBAHA121316090doi: 10.1161/ATVBAHA.121.316090.
Snarski, P., Sukhanov, S., Yoshida, T., Higashi, Y., Danchuk, S., Chandrasekar, B., Tian, D., Rivera-Lopez, V., & Delafontaine, P. (2021). Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice. Arteriosclerosis, thrombosis, and vascular biology, ATVBAHA121316090. https://doi.org/10.1161/ATVBAHA.121.316090
Snarski, Patricia, et al. "Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice." Arteriosclerosis, thrombosis, and vascular biology vol. (2021): ATVBAHA121316090. doi: https://doi.org/10.1161/ATVBAHA.121.316090
Snarski P, Sukhanov S, Yoshida T, Higashi Y, Danchuk S, Chandrasekar B, Tian D, Rivera-Lopez V, Delafontaine P. Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice. Arterioscler Thromb Vasc Biol. 2021 Dec 02;ATVBAHA121316090. doi: 10.1161/ATVBAHA.121.316090. Epub 2021 Dec 02. PMID: 34852642.
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Arterioscler Thromb Vasc Biol. 2021 Dec 02;ATVBAHA121316090. doi: 10.1161/ATVBAHA.121.316090. Epub 2021 Dec 02.

Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.

Arteriosclerosis, thrombosis, and vascular biology

Patricia Snarski, Sergiy Sukhanov, Tadashi Yoshida, Yusuke Higashi, Svitlana Danchuk, Bysani Chandrasekar, Di Tian, Vikara Rivera-Lopez, Patrick Delafontaine

Affiliations

  1. Section of Cardiology, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA. (P.S., S.S., T.Y., Y.H., S.D., P.D.).
  2. Department of Physiology, Tulane University School of Medicine, New Orleans, LA. (P.S., S.S., T.Y., Y.H., S.D., P.D.).
  3. Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (B.C.).
  4. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia (B.C.).
  5. Department of Pathology, Tulane University School of Medicine, New Orleans, LA. (D.T.).
  6. Loyola University, New Orleans, LA (V.R.-L.).
  7. Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA. (P.D.).

PMID: 34852642 DOI: 10.1161/ATVBAHA.121.316090

Abstract

OBJECTIVE: IGF-1 (insulin-like growth factor 1) exerts pleiotropic effects including promotion of cellular growth, differentiation, survival, and anabolism. We have shown that systemic IGF-1 administration reduced atherosclerosis in Apoe

CONCLUSIONS: Macrophage IGF-1 overexpression reduced atherosclerotic burden and increased features of plaque stability, likely via a reduction in CXCL12-mediated monocyte recruitment and an increase in ABCA1-dependent macrophage lipid efflux.

Keywords: atherosclerosis; cell differentiation; cytokines; inflammation; intercellular signaling peptides and proteins

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