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Mohammedi K, Abouleka Y, Carpentier C, et al. Association Between the . Diabetes Care. 2021;doi: 10.2337/dc21-0973.
Mohammedi, K., Abouleka, Y., Carpentier, C., Potier, L., Dubois, S., Foussard, N., Rigalleau, V., Gautier, J. F., Gourdy, P., Charpentier, G., Roussel, R., Scheen, A., Bauduceau, B., Hadjadj, S., Alhenc-Gelas, F., Marre, M., & Velho, G. (2021). Association Between the . Diabetes care, . https://doi.org/10.2337/dc21-0973
Mohammedi, Kamel, et al. "Association Between the ." Diabetes care vol. (2021). doi: https://doi.org/10.2337/dc21-0973
Mohammedi K, Abouleka Y, Carpentier C, Potier L, Dubois S, Foussard N, Rigalleau V, Gautier JF, Gourdy P, Charpentier G, Roussel R, Scheen A, Bauduceau B, Hadjadj S, Alhenc-Gelas F, Marre M, Velho G. Association Between the . Diabetes Care. 2021 Dec 01; doi: 10.2337/dc21-0973. Epub 2021 Dec 01. PMID: 34853028.
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Diabetes Care. 2021 Dec 01; doi: 10.2337/dc21-0973. Epub 2021 Dec 01.

Association Between the .

Diabetes care

Kamel Mohammedi, Yawa Abouleka, Charlyne Carpentier, Louis Potier, Severine Dubois, Ninon Foussard, Vincent Rigalleau, Jean-François Gautier, Pierre Gourdy, Guillaume Charpentier, Ronan Roussel, André Scheen, Bernard Bauduceau, Samy Hadjadj, François Alhenc-Gelas, Michel Marre, Gilberto Velho

Affiliations

  1. Department of Endocrinology, Diabetes and Nutrition, Bordeaux University Hospital, Hôpital Haut-Lévêque, Pessac, France [email protected].
  2. Faculty of Medicine, University of Bordeaux, Bordeaux, France.
  3. Biology of Cardiovascular Diseases, INSERM U1034, Pessac, France.
  4. Centre de Recherche des Cordeliers, INSERM, Université de Paris, Sorbonne Université, Paris, France.
  5. Service d'Endocrinologie Diabétologie Nutrition, Hôpital Bichat, AP-HP, Paris, France.
  6. Service d'Endocrinologie Diabétologie Nutrition, CHU d'Angers, Angers, France.
  7. Department of Endocrinology, Diabetes and Nutrition, Bordeaux University Hospital, Hôpital Haut-Lévêque, Pessac, France.
  8. Service de Diabétologie et d'Endocrinologie, Hôpital Lariboisière, AP-HP, Université de Paris, Paris, France.
  9. Service d'Endocrinologie Diabétologie Nutrition, CHU de Toulouse, Toulouse, France.
  10. Institut des Maladies Métaboliques et Cardiovasculaires, UMR1297 INSERM/UPS, Université Toulouse 3, Toulouse, France.
  11. Center for Study and Research for Improvement of the Treatment of Diabetes, Bioparc-Génopole Évry-Corbeil, Évry, France.
  12. CHU Liège, Liège Université, Liège, Belgium.
  13. Service d'Endocrinologie, Hôpital Bégin, Saint Mandé, France.
  14. Institut du Thorax, INSERM, CNRS, Université de Nantes, CHU Nantes, Nantes, France.
  15. Clinique Ambroise Paré, Neuilly-sur-Seine, France.

PMID: 34853028 DOI: 10.2337/dc21-0973

Abstract

RESULTS: Among 1,301 participants (male 54%, age 41 ± 13 years), 90 (6.9%) had a baseline history of LLA. Baseline LLA was more prevalent in XD (7.4%) than in II genotype (4.5%, odds ratio [OR] 2.17 [95%CI 1.03-4.60]). Incident LLA occurred in 53 individuals during the 14-year follow-up and was higher in XD versus II carriers (hazard ratio 3.26 [95% CI 1.16-13.67]). This association was driven by excess risk of minor, but not major, LLA. The D allele was associated with increased prevalent LLA at the end of follow-up (OR 2.48 [1.33-4.65]). LLA was associated with higher mean (95% CI) ACE levels in II (449 [360, 539] vs. 354 [286, 423] ng/mL), but not XD (512 [454, 570] vs. 537 [488, 586]), carriers.

CONCLUSIONS: This report is the first of an independent association between

© 2022 by the American Diabetes Association.

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