Display options
Cite
Murray GL, Colombo J. Sudden Cardiac Death in the General Population: Can We Improve Risk Stratification and Prevention?. Int J Angiol. 2021;30(4):271-276doi: 10.1055/s-0041-1729629.
Murray, G. L., & Colombo, J. (2021). Sudden Cardiac Death in the General Population: Can We Improve Risk Stratification and Prevention?. The International journal of angiology : official publication of the International College of Angiology, Inc, 30(4), 271-276. https://doi.org/10.1055/s-0041-1729629
Murray, Gary L, and Colombo, Joseph. "Sudden Cardiac Death in the General Population: Can We Improve Risk Stratification and Prevention?." The International journal of angiology : official publication of the International College of Angiology, Inc vol. 30,4 (2021): 271-276. doi: https://doi.org/10.1055/s-0041-1729629
Murray GL, Colombo J. Sudden Cardiac Death in the General Population: Can We Improve Risk Stratification and Prevention?. Int J Angiol. 2021 Jul 19;30(4):271-276. doi: 10.1055/s-0041-1729629. eCollection 2021 Dec. PMID: 34853574; PMCID: PMC8608466.
Copy Download .nbib Format: NLM
Share it on

Int J Angiol. 2021 Jul 19;30(4):271-276. doi: 10.1055/s-0041-1729629. eCollection 2021 Dec.

Sudden Cardiac Death in the General Population: Can We Improve Risk Stratification and Prevention?.

The International journal of angiology : official publication of the International College of Angiology, Inc

Gary L Murray, Joseph Colombo

Affiliations

  1. Department of Cardiology, The Heart and Vascular Institute, Germantown, Tennessee.
  2. Department of Cardiology, Physio PS, INC, Atlanta, Georgia.
  3. Department of Cardiology, Autonomic Dysfunction and POTS Center, Sicklersville, New Jersey.

PMID: 34853574 PMCID: PMC8608466 DOI: 10.1055/s-0041-1729629

Abstract

A total of 15 to 20% of deaths worldwide are sudden (within 1 hour of symptom onset). Our ability to predict and prevent sudden cardiac death (SCD) in the general population, in which 85% have no known organic heart disease (OHD) or stable OHD with left ventricular ejection fraction >40%, is limited to poor. The purpose of this commentary is to suggest a new approach to SCD in this population. Oxidative stress is a common thread in development and progression of the major cardiac diseases associated with SCD. It has a profound adverse effect upon heart rate variability (HRV), sympathetic tone (S), and parasympathetic tone (P). Recently, developed technology finally has allowed accurate measures of S and P. Using this technique, the general population can be screened, those at risk for SCD can be identified with a higher degree of success, and preventative measures instituted. For example, in 133 geriatric type 2 diabetics with S and/or P abnormalities upon screening, the potent and natural antioxidant (r)α lipoic acid reduced SCD (relative risk reduction) 43% (

International College of Angiology. This article is published by Thieme.

Keywords: acute myocardial infarction; diabetes; oxidative stress; prevention; sudden cardiac death; ventricular fibrillation; α lipoic acid

Conflict of interest statement

Conflict of Interest None declared.

References

  1. Science. 1981 Jul 10;213(4504):220-2 - PubMed
  2. Int J Angiol. 2019 Sep;28(3):188-193 - PubMed
  3. Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:5047-50 - PubMed
  4. J Cardiovasc Electrophysiol. 2001 Nov;12(11):1295-301 - PubMed
  5. Am J Physiol. 1985 Oct;249(4 Pt 2):H867-75 - PubMed
  6. Acta Diabetol. 2010 Dec;47 Suppl 1:161-8 - PubMed
  7. Eur Heart J. 2014 Jul 1;35(25):1642-51 - PubMed
  8. Curr Diabetes Rev. 2017;13(5):488-497 - PubMed
  9. Int J Angiol. 2016 Sep;25(3):159-64 - PubMed
  10. Heart Int. 2014 Dec 22;9(2):66-73 - PubMed
  11. Mayo Clin Proc. 2002 Jan;77(1):45-54 - PubMed
  12. Am J Physiol. 1987 Jul;253(1 Pt 2):H176-83 - PubMed
  13. Circulation. 1996 Dec 1;94(11):2850-5 - PubMed
  14. Diabetes Metab Res Rev. 2011 Oct;27(7):639-53 - PubMed
  15. Free Radic Res. 2003 May;37(5):471-80 - PubMed
  16. Trends Pharmacol Sci. 1988 Jan;9(1):6-9 - PubMed
  17. Jpn Circ J. 1999 Jul;63(7):503-8 - PubMed
  18. Nutr Metab Cardiovasc Dis. 2018 Jun;28(6):543-556 - PubMed
  19. Toxicol Appl Pharmacol. 2006 Apr 15;212(2):167-78 - PubMed
  20. Hum Mol Genet. 2009 Jan 15;18(2):347-57 - PubMed
  21. Diabetol Metab Syndr. 2014 Jul 28;6(1):80 - PubMed
  22. Cardiovasc Drugs Ther. 2004 Jan;18(1):13-22 - PubMed
  23. Auton Neurosci. 2016 Aug;199:29-37 - PubMed
  24. Auton Neurosci. 2003 Oct 31;108(1-2):32-44 - PubMed
  25. J Trauma. 2008 Dec;65(6):1364-73 - PubMed
  26. Q J Med. 1980 Winter;49(193):95-108 - PubMed
  27. Aging (Albany NY). 2018 Feb 23;10(2):166-177 - PubMed

Publication Types