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Le Thieu MK, Homayouni A, Hæren LR, et al. Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model. Biomater Res. 2021;25(1):43doi: 10.1186/s40824-021-00245-3.
Le Thieu, M. K., Homayouni, A., Hæren, L. R., Tiainen, H., Verket, A., Ellingsen, J. E., Rønold, H. J., Wohlfahrt, J. C., Cantalapiedra, A. G., Muñoz, F. M. G., Mendaña, M. P., Lyngstadaas, S. P., & Haugen, H. J. (2021). Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model. Biomaterials research, 25(1), 43. https://doi.org/10.1186/s40824-021-00245-3
Le Thieu, Minh Khai, et al. "Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model." Biomaterials research vol. 25,1 (2021): 43. doi: https://doi.org/10.1186/s40824-021-00245-3
Le Thieu MK, Homayouni A, Hæren LR, Tiainen H, Verket A, Ellingsen JE, Rønold HJ, Wohlfahrt JC, Cantalapiedra AG, Muñoz FMG, Mendaña MP, Lyngstadaas SP, Haugen HJ. Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model. Biomater Res. 2021 Nov 25;25(1):43. doi: 10.1186/s40824-021-00245-3. PMID: 34823602; PMCID: PMC8620131.
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Biomater Res. 2021 Nov 25;25(1):43. doi: 10.1186/s40824-021-00245-3.

Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model.

Biomaterials research

Minh Khai Le Thieu, Amin Homayouni, Lena Ringsby Hæren, Hanna Tiainen, Anders Verket, Jan Eirik Ellingsen, Hans Jacob Rønold, Johan Caspar Wohlfahrt, Antonio Gonzalez Cantalapiedra, Fernando Maria Guzon Muñoz, Maria Permuy Mendaña, Ståle Petter Lyngstadaas, Håvard Jostein Haugen

Affiliations

  1. Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317, Oslo, Norway.
  2. Department of Periodontology, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
  3. Department of Prosthetic Dentistry and Oral Function, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
  4. Universidade de Santiago de Compostela, Facultad de Veterinaria, Campus Universitario, s/n, 27002, Lugo, Spain.
  5. Ibonelab S.L., Laboratory of Biomaterials, Avda. da Coruña, 500 (CEI-NODUS), 27003, Lugo, Spain.
  6. Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317, Oslo, Norway. [email protected].

PMID: 34823602 PMCID: PMC8620131 DOI: 10.1186/s40824-021-00245-3

Abstract

BACKGROUND: Insufficient bone volume around an implant is a common obstacle when dental implant treatment is considered. Limited vertical or horizontal bone dimensions may lead to exposed implant threads following placement or a gap between the bone and implant. This is often addressed by bone augmentation procedures prior to or at the time of implant placement. This study evaluated bone healing when a synthetic TiO

METHODS: The mandibular premolars were extracted and the alveolar bone left to heal for 4 weeks prior to implant placement in six minipigs. Two cylindrical defects were created in each hemi-mandible and were subsequent to implant placement allocated to treatment with either TiO

RESULTS: MicroCT analysis demonstrated no differences between the groups for defect fill. Three of twelve scaffolds were partly fractured. At the buccal sites, histomorphometric analysis demonstrated higher bone fraction, higher percentage bone to implant contact and shorter distance from implant top to bone 0.5 mm lateral to implant surface in sham group as compared to the TiO

CONCLUSIONS: This study demonstrated less bone formation with the use of TiO

© 2021. The Author(s).

Keywords: Animal experimentation; Bone ring technique; Bone substitute

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