Display options
Cite
Fan L, Choy JS, Raissi F, et al. Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model. Comput Biol Med. 2021;105050doi: 10.1016/j.compbiomed.2021.105050.
Fan, L., Choy, J. S., Raissi, F., Kassab, G. S., & Lee, L. C. (2021). Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model. Computers in biology and medicine, 105050. https://doi.org/10.1016/j.compbiomed.2021.105050
Fan, Lei, et al. "Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model." Computers in biology and medicine vol. (2021): 105050. doi: https://doi.org/10.1016/j.compbiomed.2021.105050
Fan L, Choy JS, Raissi F, Kassab GS, Lee LC. Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model. Comput Biol Med. 2021 Nov 19;105050. doi: 10.1016/j.compbiomed.2021.105050. Epub 2021 Nov 19. PMID: 34823858.
Copy Download .nbib Format: NLM
Share it on

Comput Biol Med. 2021 Nov 19;105050. doi: 10.1016/j.compbiomed.2021.105050. Epub 2021 Nov 19.

Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model.

Computers in biology and medicine

Lei Fan, Jenny S Choy, Farshad Raissi, Ghassan S Kassab, Lik Chuan Lee

Affiliations

  1. Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA. Electronic address: [email protected].
  2. California Medical Innovations Institute, San Diego, CA, USA.
  3. Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
  4. Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA.

PMID: 34823858 DOI: 10.1016/j.compbiomed.2021.105050

Abstract

Cardiac resynchronization therapy (CRT) is an established treatment for left bundle branch block (LBBB) resulting in mechanical dyssynchrony. Approximately 1/3 of patients with CRT, however, are non-responders. To understand factors affecting CRT response, an electromechanics-perfusion computational model based on animal-specific left ventricular (LV) geometry and coronary vascular networks located in the septum and LV free wall is developed. The model considers contractility-flow and preload-activation time relationships, and is calibrated to simultaneously match the experimental measurements in terms of the LV pressure, volume waveforms and total coronary flow in the left anterior descending and left circumflex territories from 2 swine models under right atrium and right ventricular pacing. The model is then applied to investigate the responses of CRT indexed by peak LV pressure and (dP/dt)

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Cardiac resynchronization therapy; Computational modeling; Coronary perfusion; Left ventricular mechanics; Mechanical dyssynchrony

Publication Types