Display options
Cite
Corbin S, Togawa K, Schüz J, et al. Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden. Int Arch Occup Environ Health. 2021;doi: 10.1007/s00420-021-01818-4.
Corbin, S., Togawa, K., Schüz, J., Le Cornet, C., Fervers, B., Feychting, M., Wiebert, P., Hansen, J., Dalton, S. O., Kjærheim, K., Nordby, K. C., Østrem, R. S., Skakkebæk, N. E., Uuksulainen, S., Pukkala, E., & Olsson, A. (2021). Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden. International archives of occupational and environmental health, . https://doi.org/10.1007/s00420-021-01818-4
Corbin, Sara, et al. "Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden." International archives of occupational and environmental health vol. (2021). doi: https://doi.org/10.1007/s00420-021-01818-4
Corbin S, Togawa K, Schüz J, Le Cornet C, Fervers B, Feychting M, Wiebert P, Hansen J, Dalton SO, Kjærheim K, Nordby KC, Østrem RS, Skakkebæk NE, Uuksulainen S, Pukkala E, Olsson A. Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden. Int Arch Occup Environ Health. 2021 Dec 01; doi: 10.1007/s00420-021-01818-4. Epub 2021 Dec 01. PMID: 34853884.
Copy Download .nbib Format: NLM
Share it on

Int Arch Occup Environ Health. 2021 Dec 01; doi: 10.1007/s00420-021-01818-4. Epub 2021 Dec 01.

Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden.

International archives of occupational and environmental health

Sara Corbin, Kayo Togawa, Joachim Schüz, Charlotte Le Cornet, Beatrice Fervers, Maria Feychting, Pernilla Wiebert, Johnni Hansen, Susanne Oksbjerg Dalton, Kristina Kjærheim, Karl-Christian Nordby, Ragnhild Strand Østrem, Niels E Skakkebæk, Sanni Uuksulainen, Eero Pukkala, Ann Olsson

Affiliations

  1. Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 150 cours Albert Thomas, 69372, Lyon Cedex 08, France.
  2. Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
  3. Prevention Cancer Environment Department, Centre Léon Bérard, University of Lyon, Lyon, France.
  4. Inserm UMR 1296 Radiations: Defence, Health, Environment, Lyon, France.
  5. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  6. Danish Cancer Society Research Center, Copenhagen, Denmark.
  7. Department of Research, Cancer Registry of Norway, Oslo, Norway.
  8. National Institute of Occupational Health, Oslo, Norway.
  9. Department of Growth and Reproduction and International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Copenhagen, Denmark.
  10. Finnish Institute of Occupational Health (FIOH), Helsinki, Finland.
  11. Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
  12. Finland School of Health Sciences, University of Tampere, Tampere, Finland.
  13. Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), 150 cours Albert Thomas, 69372, Lyon Cedex 08, France. [email protected].

PMID: 34853884 DOI: 10.1007/s00420-021-01818-4

Abstract

OBJECTIVE: We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring.

METHODS: NORD-TEST, a registry-based case-control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14-49 years between 1978 and 2012 with no history of prior cancer, and up to four controls matched to each case on year and country of birth. Parents of cases and controls were identified via linkages with the population registries and their occupational information was retrieved from censuses. The Nordic Occupational Cancer Study Job-Exposure Matrix was used to assign occupational exposures to each parent. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).

RESULTS: Maternal wood-related job was not associated with the risk of TGCT in offspring (OR 1.08, CI 0.55-2.14), while paternal wood-related job was associated with a decreased risk of TGCT in offspring (OR 0.85, CI 0.75-0.96). None of the specific wood-related jobs, such as upholsterers, sawyers, or construction carpenters, were significantly associated with a risk of TGCT. Only exception was observed in a sensitivity analysis which showed an increased risk in the small group of sons of fathers working as 'cabinetmakers and joiners' the year before conception (OR of 2.06, CI 1.00-4.25).

CONCLUSION: This large-scale NORD-TEST analysis provided no evidence of an association between parental prenatal exposures in wood-related jobs and TGCT in sons.

© 2021. The Author(s).

Keywords: Nordic countries; Occupational exposure; Prenatal exposure delayed effects; Testicular germ cell tumours; Testicular neoplasms; Wood-related jobs

References

  1. Archibong AE, Rideout ML, Harris KJ, Ramesh A (2018) Oxidative stress in reproductive toxicology. Curr Opin Toxicol 7:95–101. https://doi.org/10.1016/j.cotox.2017.10.004 - PubMed
  2. Baird DC, Meyers GJ, Hu JS (2018) Testicular cancer: diagnosis and treatment. Am Fam Physician 97(4):261–268 - PubMed
  3. Béranger R, Le Cornet C, Schüz J, Fervers B (2013) Occupational and environmental exposures associated with testicular germ cell tumours: systematic review of prenatal and life-long exposures. PLoS ONE 8(10):e77130. https://doi.org/10.1371/journal.pone.0077130 - PubMed
  4. Dement J, Pompeii L, Lipkus IM, Samsa GP (2003) Cancer incidence among union carpenters in New Jersey. J Occup Environ Med 45(10):1059–1067. https://doi.org/10.1097/01.jom.0000085892.01486.6a - PubMed
  5. Duong A, Steinmaus C, McHale CM, Vaughan CP, Zhang L (2011) Reproductive and developmental toxicity of formaldehyde: a systematic review. Mutat Res 728(3):118–138. https://doi.org/10.1016/j.mrrev.2011.07.003 - PubMed
  6. Dutta S, Sengupta P, Slama P, Roychoudhury S (2021) Oxidative stress, testicular inflammatory pathways, and male reproduction. Int J Mol Sci 22(18):10043. https://doi.org/10.3390/ijms221810043 - PubMed
  7. Ferlay J et al (2021) Cancer statistics for the year 2020: an overview. Int J Cancer. https://doi.org/10.1002/ijc.33588 - PubMed
  8. Feychting M, Plato N, Nise G, Ahlbom A (2001) Paternal occupational exposures and childhood cancer. Environ Health Perspect 109(2):193–196. https://doi.org/10.1289/ehp.01109193 - PubMed
  9. Ghelli F et al (2021) Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde. J Occup Med Toxicol 16(1):4. https://doi.org/10.1186/s12995-021-00293-4 - PubMed
  10. Gilligan T et al (2019) Testicular cancer, version 2. 2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 17(12):1529–1554. https://doi.org/10.6004/jnccn.2019.0058 - PubMed
  11. Guvenius DM, Aronsson A, Ekman-Ordeberg G, Bergman A, Norén K (2003) Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol. Environ Health Perspect 111(9):1235–1241. https://doi.org/10.1289/ehp.5946 - PubMed
  12. Hakulinen T, Andersen A, Malker B, Pukkala E, Schou G, Tulinius H (1986) Trends in cancer incidence in the Nordic countries. A collaborative study of the five Nordic Cancer Registries. Acta Pathol Microbiol Immunol Scand Suppl 288:1–151 - PubMed
  13. Huyghe E, Plante P, Thonneau PF (2007) Testicular cancer variations in time and space in Europe. Eur Urol 51(3):621–628. https://doi.org/10.1016/j.eururo.2006.08.024 - PubMed
  14. Kardaun JW, Hayes RB, Pottern LM, Brown LM, Hoover RN (1991) Testicular cancer in young men and parental occupational exposure. Am J Ind Med 20(2):219–227 - PubMed
  15. Kauppinen T et al (2009) Construction of job-exposure matrices for the Nordic Occupational Cancer Study (NOCCA). Acta Oncol 48(5):791–800. https://doi.org/10.1080/02841860902718747 - PubMed
  16. Knight JA, Marrett LD (1997) Parental occupational exposure and the risk of testicular cancer in Ontario. J Occup Environ Med 39(4):333–338 - PubMed
  17. Lacson JC, Carroll JD, Tuazon E, Castelao EJ, Bernstein L, Cortessis VK (2012) Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk. Cancer 118(21):5374–5383. https://doi.org/10.1002/cncr.27554 - PubMed
  18. Le Cornet C et al (2017) Parental occupational exposure to organic solvents and testicular germ cell tumors in their offspring: NORD-TEST study. Environ Health Perspect 125(6):067023. https://doi.org/10.1289/EHP864 - PubMed
  19. McGlynn KA, Trabert B (2012) Adolescent and adult risk factors for testicular cancer. Nat Rev Urol 9(6):339–349. https://doi.org/10.1038/nrurol.2012.61 - PubMed
  20. Meijer L et al (2012) Influence of prenatal organohalogen levels on infant male sexual development: sex hormone levels, testes volume and penile length. Hum Reprod 27(3):867–872. https://doi.org/10.1093/humrep/der426 - PubMed
  21. Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (2016) The 2016 WHO classification of tumours of the urinary system and male genital organs-part A: renal, penile, and testicular tumours. Eur Urol 70(1):93–105. https://doi.org/10.1016/j.eururo.2016.02.029 - PubMed
  22. Olsson A et al (2018) Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark). Scand J Work Environ Health. https://doi.org/10.5271/sjweh.3732 - PubMed
  23. Parekh NV, Lundy SD, Vij SC (2020) Fertility considerations in men with testicular cancer. Transl Androl Urol 9(Suppl 1):S14-s23. https://doi.org/10.21037/tau.2019.08.08 - PubMed
  24. Pereira SC, Oliveira PF, Oliveira SR, Pereira ML, Alves MG (2021) Impact of environmental and lifestyle use of chromium on male fertility: focus on antioxidant activity and oxidative stress. Antioxidants (basel) 10(9):1365. https://doi.org/10.3390/antiox10091365 - PubMed
  25. Pleskacova J et al (2010) Tumor risk in disorders of sex development. Sex Dev 4(4–5):259–269. https://doi.org/10.1159/000314536 - PubMed
  26. Pukkala E et al (2009) Occupation and cancer—follow-up of 15 million people in five Nordic countries. Acta Oncol 48(5):646–790. https://doi.org/10.1080/02841860902913546 - PubMed
  27. Pukkala E et al (2018) Nordic cancer registries—an overview of their procedures and data comparability. Acta Oncol 57(4):440–455. https://doi.org/10.1080/0284186x.2017.1407039 - PubMed
  28. Rana SV (2014) Perspectives in endocrine toxicity of heavy metals—a review. Biol Trace Elem Res 160(1):1–14. https://doi.org/10.1007/s12011-014-0023-7 - PubMed
  29. Schaffar R, Pant S, Bouchardy C, Schubert H, Rapiti E (2019) Testicular cancer in Geneva, Switzerland, 1970–2012: incidence trends, survival and risk of second cancer. BMC Urol 19(1):64. https://doi.org/10.1186/s12894-019-0494-0 - PubMed
  30. Schmiedel S, Schüz J, Skakkebaek NE, Johansen C (2010) Testicular germ cell cancer incidence in an immigration perspective, Denmark, 1978 to 2003. J Urol 183(4):1378–1382. https://doi.org/10.1016/j.juro.2009.12.058 - PubMed
  31. Sharpe RM, Skakkebaek NE (1993) Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341(8857):1392–1395. https://doi.org/10.1016/0140-6736(93)90953-e - PubMed
  32. Skakkebaek NE, Berthelsen JG, Giwercman A, Müller J (1987) Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 10(1):19–28. https://doi.org/10.1111/j.1365-2605.1987.tb00161.x - PubMed
  33. Skakkebaek NE, Rajpert-De Meyts E, Main KM (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16(5):972–978 - PubMed
  34. Sonne SB et al (2009) Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Res 69(12):5241–5250. https://doi.org/10.1158/0008-5472.Can-08-4554 - PubMed
  35. Stang A, Ahrens W, Baumgardt-Elms C, Bromen K, Stegmaier C, Jöckel KH (2005) Carpenters, cabinetmakers, and risk of testicular germ cell cancer. J Occup Environ Med 47(3):299–305. https://doi.org/10.1097/01.jom.0000155716.63919.0a - PubMed
  36. Sujatha R, Chitra KC, Latchoumycandane C, Mathur PP (2001) Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats. Asian J Androl 3(2):135–138 - PubMed
  37. Togawa K et al (2016) Parental occupational exposure to heavy metals and welding fumes and risk of testicular germ cell tumors in offspring: a registry-based case-control study. Cancer Epidemiol Biomarkers Prev 25(10):1426–1434. https://doi.org/10.1158/1055-9965.epi-16-0328 - PubMed
  38. Vallières E, Pintos J, Parent ME, Siemiatycki J (2015) Occupational exposure to wood dust and risk of lung cancer in two population-based case–control studies in Montreal, Canada. Environ Health 14:1. https://doi.org/10.1186/1476-069x-14-1 - PubMed
  39. Znaor A, Lortet-Tieulent J, Jemal A, Bray F (2014) International variations and trends in testicular cancer incidence and mortality. Eur Urol 65(6):1095–1106. https://doi.org/10.1016/j.eururo.2013.11.004 - PubMed

Publication Types