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Jansen LJM, Nijssen R, Bolck YJC, et al. Systematic assessment of acquisition and data-processing parameters in the suspect screening of veterinary drugs in archive matrices using LC-HRMS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021;1-13doi: 10.1080/19440049.2021.1999507.
Jansen, L. J. M., Nijssen, R., Bolck, Y. J. C., Wegh, R. S., van de Schans, M. G. M., & Berendsen, B. J. A. (2021). Systematic assessment of acquisition and data-processing parameters in the suspect screening of veterinary drugs in archive matrices using LC-HRMS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 1-13. https://doi.org/10.1080/19440049.2021.1999507
Jansen, Larissa J M, et al. "Systematic assessment of acquisition and data-processing parameters in the suspect screening of veterinary drugs in archive matrices using LC-HRMS." Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment vol. (2021): 1-13. doi: https://doi.org/10.1080/19440049.2021.1999507
Jansen LJM, Nijssen R, Bolck YJC, Wegh RS, van de Schans MGM, Berendsen BJA. Systematic assessment of acquisition and data-processing parameters in the suspect screening of veterinary drugs in archive matrices using LC-HRMS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 Dec 02;1-13. doi: 10.1080/19440049.2021.1999507. Epub 2021 Dec 02. PMID: 34854800.
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Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 Dec 02;1-13. doi: 10.1080/19440049.2021.1999507. Epub 2021 Dec 02.

Systematic assessment of acquisition and data-processing parameters in the suspect screening of veterinary drugs in archive matrices using LC-HRMS.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Larissa J M Jansen, Rosalie Nijssen, Yvette J C Bolck, Robin S Wegh, Milou G M van de Schans, Bjorn J A Berendsen

Affiliations

  1. Authenticity & Veterinary Drugs, Wageningen Food Safety Research, Wageningen, The Netherlands.
  2. Contaminants & Toxicology, Wageningen Food Safety Research, Wageningen, The Netherlands.

PMID: 34854800 DOI: 10.1080/19440049.2021.1999507

Abstract

Monitoring strategies for veterinary drugs in products of animal origin are shifting towards a more risk-based approach. Such strategies not only target a limited number of predefined .substances but also facilitate detection of unexpected substances. By combining the use of archive matrices such as feather meal with suspect-screening methods, early detection of new hazards in the food and feed industry can be achieved. Effective application of such strategies is hampered by complex data interpretation and therefore, targeted data analysis is commonly applied. In this study, the performance of a suspect-screening data processing workflow using a suspect list or the online spectral database mzCloud

Keywords: LC-HRMS; Suspect screening; antibiotics; feather meal; mzCloud; risk-based monitoring

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