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Pasrija D, Assioun J, Sallam M, et al. Inhalational Anesthesia for Near-fatal Pediatric Asthma Complicated by Malignant Hyperthermia. Cureus. 2021;13(10):e19032doi: 10.7759/cureus.19032.
Pasrija, D., Assioun, J., Sallam, M., & Prout, A. (2021). Inhalational Anesthesia for Near-fatal Pediatric Asthma Complicated by Malignant Hyperthermia. Cureus, 13(10), e19032. https://doi.org/10.7759/cureus.19032
Pasrija, Davij, et al. "Inhalational Anesthesia for Near-fatal Pediatric Asthma Complicated by Malignant Hyperthermia." Cureus vol. 13,10 (2021): e19032. doi: https://doi.org/10.7759/cureus.19032
Pasrija D, Assioun J, Sallam M, Prout A. Inhalational Anesthesia for Near-fatal Pediatric Asthma Complicated by Malignant Hyperthermia. Cureus. 2021 Oct 25;13(10):e19032. doi: 10.7759/cureus.19032. eCollection 2021 Oct. PMID: 34824940; PMCID: PMC8612104.
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Cureus. 2021 Oct 25;13(10):e19032. doi: 10.7759/cureus.19032. eCollection 2021 Oct.

Inhalational Anesthesia for Near-fatal Pediatric Asthma Complicated by Malignant Hyperthermia.

Cureus

Davij Pasrija, Justin Assioun, Mohammad Sallam, Andrew Prout

Affiliations

  1. Department of Pediatric Critical Care, University at Buffalo, Buffalo, USA.
  2. Department of Pediatrics, University at Buffalo, Buffalo, USA.

PMID: 34824940 PMCID: PMC8612104 DOI: 10.7759/cureus.19032

Abstract

Acute severe asthma is a commonly encountered condition in the pediatric emergency room and the pediatric intensive care unit (PICU). Its treatment involves the use of bronchodilatory agents acting on different receptors, steroids to reduce ongoing inflammation, and non-invasive or invasive mechanical ventilation to offload the increased work of breathing from the respiratory muscles. Patients refractory to these therapies may require the use of inhaled anesthetic agents and extracorporeal gas exchange (ECMO) for life-threatening asthma exacerbations. Depending on institutional protocols, the use of these therapies may vary. The use of inhaled anesthetic agents for asthma management in the PICU is infrequent and is limited to centers with specialized equipment. Commonly encountered side effects include hypotension, arrhythmias, and delirium. Malignant hyperthermia (MH) is a well-known but infrequent side effect of inhaled anesthetic use, depolarizing muscle agents, and has not been described in the PICU following the use of anesthetics for pediatric asthma.

Copyright © 2021, Pasrija et al.

Keywords: asthma; extracorporeal gas exchange; inhaled anesthetic agents; isoflurane; malignant hyperthermia

Conflict of interest statement

The authors have declared that no competing interests exist.

References

  1. Respir Care. 2012 Nov;57(11):1857-64 - PubMed
  2. Pediatr Crit Care Med. 2013 Nov;14(9):851-61 - PubMed
  3. Paediatr Anaesth. 2009 Nov;19(11):1113-8 - PubMed
  4. Chest. 1990 Mar;97(3):698-701 - PubMed
  5. Anesthesiology. 1994 Apr;80(4):771-9 - PubMed
  6. Respir Care. 2017 Jun;62(6):849-865 - PubMed
  7. Orphanet J Rare Dis. 2015 Aug 04;10:93 - PubMed
  8. J Intensive Care Med. 2009 Nov-Dec;24(6):361-71 - PubMed
  9. Anesthesiology. 2008 Feb;108(2):216-24 - PubMed

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