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Yashin AI, Wu D, Arbeev K, et al. Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans. J Transl Genet Genom. 2021;5(4):357-379
Yashin, A. I., Wu, D., Arbeev, K., Yashkin, A. P., Akushevich, I., Bagley, O., Duan, M., & Ukraintseva, S. (2021). Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans. Journal of translational genetics and genomics, 5(4), 357-379.
Yashin, Anatoliy I, et al. "Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans." Journal of translational genetics and genomics vol. 5,4 (2021): 357-379.
Yashin AI, Wu D, Arbeev K, Yashkin AP, Akushevich I, Bagley O, Duan M, Ukraintseva S. Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans. J Transl Genet Genom. 2021;5(4):357-379. Epub 2021 Oct 19. PMID: 34825130; PMCID: PMC8612394.
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J Transl Genet Genom. 2021;5(4):357-379. Epub 2021 Oct 19.

Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.

Journal of translational genetics and genomics

Anatoliy I Yashin, Deqing Wu, Konstantin Arbeev, Arseniy P Yashkin, Igor Akushevich, Olivia Bagley, Matt Duan, Svetlana Ukraintseva

Affiliations

  1. Biodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.

PMID: 34825130 PMCID: PMC8612394

Abstract

AIM: Experimental studies provided numerous evidence that caloric/dietary restriction may improve health and increase the lifespan of laboratory animals, and that the interplay among molecules that sense cellular stress signals and those regulating cell survival can play a crucial role in cell response to nutritional stressors. However, it is unclear whether the interplay among corresponding genes also plays a role in human health and lifespan.

METHODS: Literature about roles of cellular stressors have been reviewed, such as amino acid deprivation, and the integrated stress response (ISR) pathway in health and aging. Single nucleotide polymorphisms (SNPs) in two candidate genes (

RESULTS: Significant interactions have been found between SNPs from

CONCLUSION: Identifying associations of the genetic interactions with human survival is an important step in translating the knowledge from experimental to human aging research. Significant associations of multiple SNPxSNP interactions in ISR genes with survival to the oldest old age that have been found in this study, can help uncover mechanisms of multifactorial regulation of human lifespan and its heterogeneity.

Keywords: GCN2/EIF2AK4 and CHOP/DDI3T genes; GxG interactions; Integrated stress response; amino acids starvation; health and lifespan

Conflict of interest statement

Conflicts of interest All authors declared that there are no conflicts of interest.

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