Medicine (Baltimore). 2021 Nov 19;100(46):e27803. doi: 10.1097/MD.0000000000027803.
Glucose tolerance in fibromyalgia.
Medicine
Teemu Zetterman, Ritva Markkula, Eija Kalso
Affiliations
Affiliations
- Department of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University and Helsinki University Hospital, Uusimaa, Finland.
- Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; City of Vantaa Health Centre, Vantaa, Finland.
- Sleepwell Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
PMID: 34797307
PMCID: PMC8601335 DOI: 10.1097/MD.0000000000027803
Abstract
OBJECTIVES: Fibromyalgia (FM) patients have an increased risk for glucose metabolism disturbances, and impaired glucose tolerance may be associated with symptom severity. Elevated levels of plasma lactate have been detected in FM patients. Both pyruvate and lactate are produced in glucose metabolism and reflect oxidative metabolism. The objective of our study was to analyse disturbances in glucose, pyruvate, or lactate metabolism in FM patients.
METHODS: We measured plasma levels of glucose, pyruvate, and lactate during an oral glucose tolerance test in 40 non-diabetic, female FM patients and 30 age- and gender-matched healthy controls.
RESULTS: FM patients showed a higher glycaemic response to the glucose load at 1 hour (F [1,68] = 10.4, P = .006) and 2 hours (F [1,68] = 7.80, P = .02), and higher glucose area under the curve (13.8 [SD 2.92] vs 11.6 [SD 2.31], P < .01), than healthy controls. Group differences were explained by higher body mass index and percentage of smokers among the FM patients. Pyruvate and lactate levels were similar in both groups.
DISCUSSION: Impaired glucose regulation in FM patients is likely not due to FM itself, but to associated lifestyle factors. Our results highlight the importance of assessing the glucose regulation status and the lifestyle factors affecting glucose regulation in FM patients for prevention or early treatment of diabetes and associated complications.
TRIAL REGISTRATION: ClinicalTrials.gov (NCT03300635).
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Conflict of interest statement
The other authors have no conflicts of interest to disclose.
References
- J Rheumatol. 1991 May;18(5):728-33 - PubMed
- Rheumatol Int. 2011 Nov;31(11):1403-8 - PubMed
- BMC Musculoskelet Disord. 2014 Oct 28;15:357 - PubMed
- Mediators Inflamm. 2014;2014:627041 - PubMed
- Pain. 2006 Jan;120(1-2):161-169 - PubMed
- Nutrients. 2020 Aug 20;12(9): - PubMed
- Arthritis Care Res (Hoboken). 2010 May;62(5):611-7 - PubMed
- Int J Obes (Lond). 2007 Jan;31(1):114-20 - PubMed
- Diabetes Res Clin Pract. 2011 Aug;93(2):268-275 - PubMed
- J Rheumatol. 2003 Apr;30(4):809-14 - PubMed
- Pain Med. 2015 Jul;16(7):1433-42 - PubMed
- Reumatologia. 2018;56(5):275-278 - PubMed
- Rheumatol Int. 2009 Sep;29(11):1311-4 - PubMed
- Clin Exp Rheumatol. 2020 Jan-Feb;38 Suppl 123(1):47-52 - PubMed
- BMC Rheumatol. 2018 Dec 12;2:38 - PubMed
- Scand J Rheumatol. 2002;31(5):301-5 - PubMed
- BMJ. 2016 Nov 23;355:i5953 - PubMed
- PLoS One. 2016 Oct 3;11(10):e0162010 - PubMed
- Diabetologia. 2017 Aug;60(8):1370-1381 - PubMed
- Joint Bone Spine. 2011 May;78(3):259-65 - PubMed
- J Cereb Blood Flow Metab. 2009 Jun;29(6):1121-9 - PubMed
- BMC Musculoskelet Disord. 2016 Jan 15;17:29 - PubMed
- J Pain. 2017 Dec;18(12):1542-1550 - PubMed
- BMC Musculoskelet Disord. 2021 Feb 14;22(1):183 - PubMed
- Scand J Pain. 2017 Dec 29;3(1):15-20 - PubMed
- Arthritis Rheum. 1990 Feb;33(2):160-72 - PubMed
- Mitochondrion. 2014 Jul;17:76-100 - PubMed
- Eur J Transl Myol. 2019 May 09;29(2):8202 - PubMed
- Clin J Pain. 2014 May;30(5):409-20 - PubMed
- Rheumatol Int. 2003 Jul;23(4):171-3 - PubMed
- Diabetologia. 2020 Nov;63(11):2359-2371 - PubMed
- Am J Med. 1999 May;106(5):534-43 - PubMed
- Rheumatology (Oxford). 2008 Aug;47(8):1235-8 - PubMed
- Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):381-91 - PubMed
- Mayo Clin Proc Innov Qual Outcomes. 2019 Feb 26;3(1):78-85 - PubMed
- Diabetes Res Clin Pract. 2009 Jul;85(1):4-13 - PubMed
- Endocr Dev. 2010;17:11-21 - PubMed
- Trends Neurosci. 2013 Oct;36(10):587-97 - PubMed
- Pain Pract. 2016 Nov;16(8):1054-1063 - PubMed
- Eur J Epidemiol. 2015 Jul;30(7):529-42 - PubMed
- Metabolism. 2007 Jan;56(1):87-93 - PubMed
- Semin Arthritis Rheum. 2016 Dec;46(3):319-329 - PubMed
- Clin Endocrinol (Oxf). 2001 Oct;55(4):455-9 - PubMed
- Nicotine Tob Res. 2020 Jan 27;22(1):135-140 - PubMed
- J Pain Res. 2014 Jun 12;7:313-26 - PubMed
- Semin Arthritis Rheum. 2021 Apr;51(2):409-424 - PubMed
- Metab Brain Dis. 2013 Dec;28(4):619-27 - PubMed
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