Display options
Cite
Mena G, Casas I, Casañ C, et al. Influenza vaccination coverage and factors associated with severe laboratory-confirmed influenza-related illness in patients receiving care at a tertiary hospital in Catalonia (Spain) during the 2018-2019 epidemic season. PLoS One. 2021;16(12):e0260397doi: 10.1371/journal.pone.0260397.
Mena, G., Casas, I., Casañ, C., Auñón, M., Matas, L., Mòdol, J. M., & Esteve, M. (2021). Influenza vaccination coverage and factors associated with severe laboratory-confirmed influenza-related illness in patients receiving care at a tertiary hospital in Catalonia (Spain) during the 2018-2019 epidemic season. PloS one, 16(12), e0260397. https://doi.org/10.1371/journal.pone.0260397
Mena, Guillermo, et al. "Influenza vaccination coverage and factors associated with severe laboratory-confirmed influenza-related illness in patients receiving care at a tertiary hospital in Catalonia (Spain) during the 2018-2019 epidemic season." PloS one vol. 16,12 (2021): e0260397. doi: https://doi.org/10.1371/journal.pone.0260397
Mena G, Casas I, Casañ C, Auñón M, Matas L, Mòdol JM, Esteve M. Influenza vaccination coverage and factors associated with severe laboratory-confirmed influenza-related illness in patients receiving care at a tertiary hospital in Catalonia (Spain) during the 2018-2019 epidemic season. PLoS One. 2021 Dec 02;16(12):e0260397. doi: 10.1371/journal.pone.0260397. eCollection 2021. PMID: 34855801; PMCID: PMC8638936.
Copy Download .nbib Format: NLM
Share it on

PLoS One. 2021 Dec 02;16(12):e0260397. doi: 10.1371/journal.pone.0260397. eCollection 2021.

Influenza vaccination coverage and factors associated with severe laboratory-confirmed influenza-related illness in patients receiving care at a tertiary hospital in Catalonia (Spain) during the 2018-2019 epidemic season.

PloS one

Guillermo Mena, Irma Casas, Cristina Casañ, Mario Auñón, Lurdes Matas, Josep-Maria Mòdol, María Esteve

Affiliations

  1. Servicio de Medicina Preventiva, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  2. Universitat Autònoma de Barcelona, Barcelona, Spain.
  3. Servicio de Microbiologia, Laboratori Clínic Metropolitana Nord, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  4. CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
  5. Dirección Médica, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

PMID: 34855801 PMCID: PMC8638936 DOI: 10.1371/journal.pone.0260397

Abstract

INTRODUCTION: Influenza vaccination rates in risk groups remain suboptimal. Evidence supporting a significant association between influenza vaccination and severe illness is limited.

METHODS: We retrospectively analyzed the epidemiological characteristics of out- and inpatients with laboratory-confirmed influenza infection attended during the 2018-19 epidemic season. Influenza vaccination coverage by indication was analyzed. Logistic regression was used to compare the odds of vaccination between severe and non-severe influenza-positive patients. Severe cases were defined as presenting pneumonia, admission to critical care units and/or death.

RESULTS: The overall vaccination coverage among influenza-positive patients was 30.4%. In subjects with ≥ 1 indication for vaccination, the vaccination coverage was 42.4%. By indication, coverage rates were: 52.5% in patients aged ≥ 59 years, 42.2% in obese patients, 29.2% in immunosuppressed subjects and 6.5% in pregnant women. In patients with underlying chronic diseases, a higher coverage was found in patients with cognitive impairment (77%), muscular dystrophy (63.6%) and renal disease (60.4%). The multivariate logistic regression model showed severe influenza-related illness was associated with a lack of influenza vaccination before seeking care during the 2018-2019 season [0.59 (95%CI 0.36-0.97); p = 0.038], older age [1.01 (95%CI 1.00-1.02); p = 0.009] and current or former smoking status [1.63 (95%CI 0.84-3.18) and 2.03 (95%CI 1.16-3.57); p = 0.031], adjusted by underlying disease.

CONCLUSION: Adjusting by age, smoking status and underlying disease, a moderate association between the influenza vaccine and severe laboratory-confirmed influenza-related illness was found in an epidemic season in which there was matching between the vaccine and circulating strains. Protection against complications, especially in older subjects and in those with underlying disease is postulated as one of the strengths of annual influenza vaccination. However, influenza vaccination is a pending issue in these groups, especially in pregnant women and obese people. To avoid suboptimal vaccination coverages, health professionals should recommend the seasonal influenza vaccination according to the annual instructions of the health authorities.

Conflict of interest statement

The authors have declared that no competing interests exist.

References

  1. Sci Rep. 2019 Sep 6;9(1):12853 - PubMed
  2. J Infect Dis. 2019 Sep 13;220(8):1265-1275 - PubMed
  3. Emerg Infect Dis. 2020 Feb;26(2):220-228 - PubMed
  4. Lancet. 2018 Mar 31;391(10127):1285-1300 - PubMed
  5. Euro Surveill. 2018 Oct;23(43): - PubMed
  6. Influenza Other Respir Viruses. 2017 Sep;11(5):372-393 - PubMed
  7. J Intern Med. 2011 Mar;269(3):258-69 - PubMed
  8. JAMA. 2013 Nov 27;310(20):2191-4 - PubMed
  9. PLoS Med. 2016 Mar 24;13(3):e1001977 - PubMed
  10. Rev Esp Salud Publica. 2019 Apr 29;93: - PubMed
  11. Eur J Public Health. 2018 Feb 1;28(1):150-155 - PubMed
  12. Med Clin (Barc). 2020 Aug 14;155(3):112-118 - PubMed
  13. Vaccine. 2020 Feb 18;38(8):1925-1932 - PubMed
  14. BMC Public Health. 2019 Aug 13;19(1):1089 - PubMed

Publication Types