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Anvekar A, Athikarisamy S, Rao S, et al. Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?. BMC Pediatr. 2021;21(1):540doi: 10.1186/s12887-021-03027-x.
Anvekar, A., Athikarisamy, S., Rao, S., Gill, A., Nathan, E., Doherty, D., & Lam, G. (2021). Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?. BMC pediatrics, 21(1), 540. https://doi.org/10.1186/s12887-021-03027-x
Anvekar, Ajay, et al. "Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?." BMC pediatrics vol. 21,1 (2021): 540. doi: https://doi.org/10.1186/s12887-021-03027-x
Anvekar A, Athikarisamy S, Rao S, Gill A, Nathan E, Doherty D, Lam G. Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?. BMC Pediatr. 2021 Dec 02;21(1):540. doi: 10.1186/s12887-021-03027-x. PMID: 34856950; PMCID: PMC8638437.
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BMC Pediatr. 2021 Dec 02;21(1):540. doi: 10.1186/s12887-021-03027-x.

Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?.

BMC pediatrics

Ajay Anvekar, Sam Athikarisamy, Shripada Rao, Andy Gill, Elizabeth Nathan, Dorota Doherty, Geoffrey Lam

Affiliations

  1. Department of Neonatal Paediatrics, Fiona Stanley hospital, Perth, Australia. [email protected].
  2. Department of Neonatal Paediatrics, Perth Children's Hospital, Perth, Australia.
  3. Department of Neonatal Paediatrics, King Edward Memorial Hospital for Women, Perth, Australia.
  4. Department of Paediatrics, University of Western Australia, Perth, Australia.
  5. Women and Infants Research Foundation, King Edward Memorial Hospital for Women, Perth, Australia.
  6. Division of Obstetrics and Gynaecology, University of Western Australia, Perth, Australia.
  7. Department of Ophthalmology, Perth Children's Hospital, Perth, Australia.
  8. Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia.

PMID: 34856950 PMCID: PMC8638437 DOI: 10.1186/s12887-021-03027-x

Abstract

BACKGROUND: Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight (BW) be used as an additional marker to identify infants with type 1 ROP.

METHODS: In this retrospective study, preterm infants (< 27 weeks gestational age at birth) born during the period from 1/1/2010-31/12/2015 at a tertiary neonatal intensive care unit in Australia were included. Twenty-seven preterm infants with Type 1 ROP were identified. Controls (No ROP or ROP other than type 1) were matched with cases on gestational age at birth and BW (1:4 ratio). Data were collected from the database and medical records.

RESULTS: The median (IQR) gestational age for Type 1 ROP and control groups were 24 (24-26) and 25 (24-26) weeks respectively and median (IQR) BW for Type 1 ROP and control groups were 675 (635-810) and 773 (666-884) grams respectively. Preterm infants with Type 1 ROP were more likely to be small for gestational age (SGA) (18.5% vs 3.7%, p = 0.015) and had increased weeks on oxygen therapy (median 11.9 vs 9.1, p = 0.028). Time to regain BW was longer in preterm infants with type 1 ROP than controls but did not reach statistical significance (median 9 vs 7 days, OR 1.08, 95% CI 1.00-1.17, p = 0.059) adjusted for SGA and duration of oxygen therapy. The area under the curve from the time to regain BW model with adjustment for SGA and duration of oxygen therapy was 0.73 (95% CI 0.62-0.83).

CONCLUSION: We hypothesize that time to regain BW has potential to aid prediction of Type 1 ROP and this warrants further investigation in a larger prospective study.

© 2021. The Author(s).

Keywords: Birth weight; Preterm; Retinopathy of prematurity

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