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Buonavoglia A, Leone P, Prete M, et al. Epstein-Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions. J Clin Med. 2021;10(21)doi: 10.3390/jcm10214995.
Buonavoglia, A., Leone, P., Prete, M., Solimando, A. G., Guastadisegno, C., Lanave, G., Camero, M., Martella, V., Lo Muzio, L., & Racanelli, V. (2021). Epstein-Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions. Journal of clinical medicine, 10(21), . https://doi.org/10.3390/jcm10214995
Buonavoglia, Alessio, et al. "Epstein-Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions." Journal of clinical medicine vol. 10,21 (2021). doi: https://doi.org/10.3390/jcm10214995
Buonavoglia A, Leone P, Prete M, Solimando AG, Guastadisegno C, Lanave G, Camero M, Martella V, Lo Muzio L, Racanelli V. Epstein-Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions. J Clin Med. 2021 Oct 27;10(21). doi: 10.3390/jcm10214995. PMID: 34768514; PMCID: PMC8584540.
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J Clin Med. 2021 Oct 27;10(21). doi: 10.3390/jcm10214995.

Epstein-Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions.

Journal of clinical medicine

Alessio Buonavoglia, Patrizia Leone, Marcella Prete, Antonio Giovanni Solimando, Chiara Guastadisegno, Gianvito Lanave, Michele Camero, Vito Martella, Lorenzo Lo Muzio, Vito Racanelli

Affiliations

  1. Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, 70124 Bari, Italy.
  2. IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
  3. Department of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy.
  4. Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.

PMID: 34768514 PMCID: PMC8584540 DOI: 10.3390/jcm10214995

Abstract

In order to investigate the possible role of Epstein-Barr virus (EBV) in systemic lupus erythematosus (SLE) and its associated oral lesions, a pilot case-control study was performed. A total of 31 patients (18 females and 13 males) were enrolled in the study and divided into two groups: group A included 16 patients with diagnosis of SLE and group B included 15 healthy individuals. Salivary swab samples were collected and subjected to molecular screening by real-time quantitative PCR (qPCR) for the detection of EBV DNA. EBV DNA was significantly detected in 8/16 (50%) SLE patients and in 5/7 (71.4%) subjects with SLE-associated oral lesions. Since EBV is one of the most common viruses in the human population, it is difficult to understand if it is the causative agent of SLE or, vice versa, if SLE is able to trigger the reactivation of EBV. This study highlights a significant association between the presence of EBV and both SLE and SLE-related oral lesions and provides rationale for further investigation into the role of EBV in SLE pathogenesis.

Keywords: Epstein–Barr virus; oral lesions; systemic lupus erythematosus

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