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Javaid S, Farooq T, Rehman Z, et al. Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities. Int J Mol Sci. 2021;22(21)doi: 10.3390/ijms222111313.
Javaid, S., Farooq, T., Rehman, Z., Afzal, A., Ashraf, W., Rasool, M. F., Alqahtani, F., Alsanea, S., Alasmari, F., Alanazi, M. M., Alharbi, M., & Imran, I. (2021). Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities. International journal of molecular sciences, 22(21), . https://doi.org/10.3390/ijms222111313
Javaid, Sana, et al. "Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities." International journal of molecular sciences vol. 22,21 (2021). doi: https://doi.org/10.3390/ijms222111313
Javaid S, Farooq T, Rehman Z, Afzal A, Ashraf W, Rasool MF, Alqahtani F, Alsanea S, Alasmari F, Alanazi MM, Alharbi M, Imran I. Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities. Int J Mol Sci. 2021 Oct 20;22(21). doi: 10.3390/ijms222111313. PMID: 34768742; PMCID: PMC8583393.
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Int J Mol Sci. 2021 Oct 20;22(21). doi: 10.3390/ijms222111313.

Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities.

International journal of molecular sciences

Sana Javaid, Talha Farooq, Zohabia Rehman, Ammara Afzal, Waseem Ashraf, Muhammad Fawad Rasool, Faleh Alqahtani, Sary Alsanea, Fawaz Alasmari, Mohammed Mufadhe Alanazi, Metab Alharbi, Imran Imran

Affiliations

  1. Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.
  2. Department of Pharmacy, The Women University, Multan 60000, Pakistan.
  3. Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.
  4. Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

PMID: 34768742 PMCID: PMC8583393 DOI: 10.3390/ijms222111313

Abstract

The incidences of traumatic brain injuries (TBIs) are increasing globally because of expanding population and increased dependencies on motorized vehicles and machines. This has resulted in increased socio-economic burden on the healthcare system, as TBIs are often associated with mental and physical morbidities with lifelong dependencies, and have severely limited therapeutic options. There is an emerging need to identify the molecular mechanisms orchestrating these injuries to life-long neurodegenerative disease and a therapeutic strategy to counter them. This review highlights the dynamics and role of choline-containing phospholipids during TBIs and how they can be used to evaluate the severity of injuries and later targeted to mitigate neuro-degradation, based on clinical and preclinical studies. Choline-based phospholipids are involved in maintaining the structural integrity of the neuronal/glial cell membranes and are simultaneously the essential component of various biochemical pathways, such as cholinergic neuronal transmission in the brain. Choline or its metabolite levels increase during acute and chronic phases of TBI because of excitotoxicity, ischemia and oxidative stress; this can serve as useful biomarker to predict the severity and prognosis of TBIs. Moreover, the effect of choline-replenishing agents as a post-TBI management strategy has been reviewed in clinical and preclinical studies. Overall, this review determines the theranostic potential of choline phospholipids and provides new insights in the management of TBI.

Keywords: brain phospholipids; choline; choline-targeted therapy; citicholine; phosphatidylcholine; traumatic brain injury

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