Int J Mol Sci. 2021 Oct 24;22(21). doi: 10.3390/ijms222111465.
Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.
International journal of molecular sciences
Ewa Szczepanska-Sadowska, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, Tymoteusz Żera
Affiliations
Affiliations
- Laboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, Poland.
PMID: 34768894
PMCID: PMC8584236 DOI: 10.3390/ijms222111465
Abstract
The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases.
Keywords: hypertension; myocardial infarction; oxytocin; stress; vasopressin
References
- Cardiovasc Res. 2017 Sep 1;113(11):1318-1328 - PubMed
- J Physiol. 2017 Jun 1;595(11):3303-3318 - PubMed
- Neuron. 2012 Oct 4;76(1):142-59 - PubMed
- Curr Hypertens Rep. 2018 Feb 26;20(2):11 - PubMed
- Curr Drug Metab. 2017;18(4):306-345 - PubMed
- Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6783-7 - PubMed
- Horm Metab Res. 1982 Apr;14(4):175-9 - PubMed
- FASEB J. 2020 May;34(5):6129-6146 - PubMed
- Heart. 2013 Oct;99(20):1525-9 - PubMed
- BMC Med. 2012 Jan 20;10:7 - PubMed
- J Physiol. 2009 Oct 1;587(Pt 19):4725-36 - PubMed
- Proc Natl Acad Sci U S A. 2000 May 23;97(11):6207-11 - PubMed
- Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11704-9 - PubMed
- J Clin Invest. 1994 Apr;93(4):1439-50 - PubMed
- Semin Nephrol. 2008 May;28(3):289-96 - PubMed
- Am J Physiol. 1983 May;244(5):E453-8 - PubMed
- Neurosci Bull. 2017 Apr;33(2):238-246 - PubMed
- Acta Endocrinol (Copenh). 1989;121 Suppl 1:3-27 - PubMed
- Curr Pharm Des. 2010;16(28):3071-88 - PubMed
- Neuropsychopharmacology. 2004 Jan;29(1):1-14 - PubMed
- Ther Adv Cardiovasc Dis. 2021 Jan-Dec;15:1753944720977741 - PubMed
- J Neuroendocrinol. 2015 Nov;27(11):835-49 - PubMed
- J Clin Invest. 1993 Nov;92(5):2339-45 - PubMed
- Annu Rev Neurosci. 1994;17:219-46 - PubMed
- Curr Hypertens Rep. 2018 Mar 19;20(3):19 - PubMed
- Blood Press. 1994 Mar;3(1-2):137-41 - PubMed
- J Neuroendocrinol. 2012 Apr;24(4):539-53 - PubMed
- Mol Cell Endocrinol. 2015 Sep 5;412:170-81 - PubMed
- Exp Physiol. 2015 Apr 20;100(5):553-65 - PubMed
- BMC Endocr Disord. 2016 Jun 07;16(1):34 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2014 Apr 1;306(7):R447-56 - PubMed
- Endocrinology. 2015 Apr;156(4):1416-28 - PubMed
- J Biol Chem. 1985 Aug 25;260(18):10236-41 - PubMed
- Hum Mol Genet. 1993 Oct;2(10):1746 - PubMed
- Endocrinology. 1995 Mar;136(3):1285-95 - PubMed
- Neuroscience. 2006 Dec 28;143(4):1031-9 - PubMed
- Am J Med Genet. 1995 Jun 19;60(3):183-7 - PubMed
- PLoS One. 2018 Apr 2;13(4):e0195407 - PubMed
- N Engl J Med. 1981 Jul 30;305(5):263-6 - PubMed
- Curr Neuropharmacol. 2020;18(1):14-33 - PubMed
- Acta Physiol (Oxf). 2010 Oct;200(2):147-58 - PubMed
- Purinergic Signal. 2014 Mar;10(1):189-231 - PubMed
- JAMA. 2007 Mar 28;297(12):1332-43 - PubMed
- J Physiol (Paris). 1984;79(6):432-9 - PubMed
- J Neurosci. 1984 Feb;4(2):474-94 - PubMed
- J Neuroendocrinol. 1999 Apr;11(4):291-7 - PubMed
- Future Med Chem. 2012 Sep;4(14):1791-8 - PubMed
- Physiology (Bethesda). 2019 Jul 1;34(4):264-282 - PubMed
- Neuroscience. 2019 May 15;406:50-61 - PubMed
- J Neuroendocrinol. 2010 May;22(5):430-7 - PubMed
- Exp Physiol. 2006 Jul;91(4):791-7 - PubMed
- Am J Hypertens. 1999 Mar;12(3):311-4 - PubMed
- Endocrinology. 1998 Apr;139(4):1481-6 - PubMed
- Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E273-85 - PubMed
- Stress. 2014 Jan;17(1):117-25 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2013 Nov 15;305(10):R1112-23 - PubMed
- J Neurosci. 2003 Apr 1;23(7):2726-34 - PubMed
- Exp Physiol. 2009 Nov;94(11):1103-13 - PubMed
- Ann N Y Acad Sci. 1995 Dec 29;771:192-203 - PubMed
- J Neuroendocrinol. 2008 Jun;20(6):880-4 - PubMed
- Neuroscience. 2013 Dec 3;253:155-64 - PubMed
- PLoS One. 2014 Nov 07;9(11):e112138 - PubMed
- Anesthesiology. 2013 Sep;119(3):541-51 - PubMed
- Trends Endocrinol Metab. 2005 Apr;16(3):81-3 - PubMed
- Front Psychol. 2020 Aug 25;11:2139 - PubMed
- Mol Cell Endocrinol. 2017 Jul 5;449:56-63 - PubMed
- Physiol Rev. 2001 Apr;81(2):629-83 - PubMed
- Br J Anaesth. 2008 May;100(5):683-9 - PubMed
- J Endocrinol. 2015 Aug;226(2):T173-85 - PubMed
- Mol Cell Biol. 2004 Sep;24(18):8048-54 - PubMed
- J Neurosci. 2009 Oct 21;29(42):13182-9 - PubMed
- Biol Psychiatry. 2016 Feb 1;79(3):174-84 - PubMed
- Front Neurosci. 2018 Dec 10;12:919 - PubMed
- Eur J Endocrinol. 2002 Dec;147(6):815-24 - PubMed
- Eur J Neurosci. 2006 Sep;24(6):1711-20 - PubMed
- Exp Physiol. 2014 Jan;99(1):55-61 - PubMed
- Cell Rep. 2017 Nov 7;21(6):1681-1691 - PubMed
- J Am Soc Hypertens. 2008 Sep-Oct;2(5):318-25 - PubMed
- Proc Natl Acad Sci U S A. 1986 Jul;83(14):5335-9 - PubMed
- Peptides. 2018 Feb;100:260-268 - PubMed
- Neuroscience. 2018 Sep 1;387:149-161 - PubMed
- Peptides. 2012 Oct;37(2):314-9 - PubMed
- J Card Fail. 2021 Feb;27(2):233-241 - PubMed
- Front Neurosci. 2017 Oct 16;11:567 - PubMed
- Brain Res Mol Brain Res. 2003 Jun 10;114(2):115-22 - PubMed
- Rev Reprod. 1996 Jan;1(1):13-8 - PubMed
- Circulation. 2007 Apr 24;115(16):2103-10 - PubMed
- Endocrinology. 1992 Jul;131(1):533-5 - PubMed
- Exp Neurol. 2001 Oct;171(2):200-9 - PubMed
- Auton Neurosci. 2007 Oct 30;136(1-2):58-62 - PubMed
- Soc Neurosci. 2017 Apr;12(2):113-123 - PubMed
- Neuroendocrinology. 2004;80(2):100-10 - PubMed
- Am J Physiol Renal Physiol. 2007 May;292(5):F1418-26 - PubMed
- J Auton Nerv Syst. 1997 Sep 10;66(1-2):15-8 - PubMed
- Endocrinology. 2007 Sep;148(9):4136-46 - PubMed
- Neuron. 2011 Jan 27;69(2):332-44 - PubMed
- Clin Sci (Lond). 1985 Jan;68(1):35-43 - PubMed
- J Neurophysiol. 1996 Aug;76(2):977-83 - PubMed
- J Neuroendocrinol. 2003 Aug;15(8):787-93 - PubMed
- Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9550-5 - PubMed
- J Neuroendocrinol. 2004 Apr;16(4):372-7 - PubMed
- Neurourol Urodyn. 2019 Jan;38(1):393-397 - PubMed
- Mol Endocrinol. 2003 Apr;17(4):677-91 - PubMed
- J Neurosci. 2014 Mar 12;34(11):3810-20 - PubMed
- Fundam Clin Pharmacol. 1995;9(1):17-24 - PubMed
- J Dairy Res. 2017 May;84(2):165-169 - PubMed
- Brain Res Bull. 2003 Jan 30;59(5):399-403 - PubMed
- Horm Behav. 2012 Mar;61(3):359-79 - PubMed
- Int J Clin Exp Pathol. 2018 Feb 01;11(2):739-747 - PubMed
- Peptides. 2019 Jan;111:142-151 - PubMed
- Exp Physiol. 2000 Mar;85 Spec No:19S-26S - PubMed
- Handb Clin Neurol. 2021;180:25-44 - PubMed
- J Pharmacol Exp Ther. 2000 Jun;293(3):852-60 - PubMed
- Recent Prog Horm Res. 1976;33:333-85 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R59-67 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1167-R1182 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2020 Jan 1;318(1):R160-R172 - PubMed
- J Am Coll Cardiol. 2014 Feb 4;63(4):375-6 - PubMed
- Prog Neurobiol. 1999 Apr;57(6):625-55 - PubMed
- J Neuroendocrinol. 2010 May;22(5):330-42 - PubMed
- J Am Coll Cardiol. 2007 Jun 5;49(22):2151-9 - PubMed
- Exp Physiol. 2000 Mar;85 Spec No:223S-231S - PubMed
- Eur J Pharmacol. 2000 Aug 11;401(3):289-96 - PubMed
- Brain Res. 1988 Jul 5;455(1):18-23 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2002 Apr;282(4):R979-84 - PubMed
- J Mol Cell Cardiol. 2000 Apr;32(4):557-64 - PubMed
- Horm Metab Res. 2010 Jan;42(1):56-60 - PubMed
- J Neuroendocrinol. 2013 Dec;25(12):1241-1254 - PubMed
- Nephrology (Carlton). 2018 Oct;23 Suppl 4:44-49 - PubMed
- Endocr Rev. 2010 Feb;31(1):98-132 - PubMed
- Am J Obstet Gynecol. 1994 Aug;171(2):470-7 - PubMed
- Endocrinology. 1998 Dec;139(12):5015-33 - PubMed
- Prog Brain Res. 2008;170:193-204 - PubMed
- Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1549-57 - PubMed
- Am J Physiol. 1979 Apr;236(4):F321-32 - PubMed
- Circ Res. 1990 Mar;66(3):710-21 - PubMed
- Neuropeptides. 2014 Oct;48(5):257-66 - PubMed
- J Endocrinol Invest. 2003;26(7 Suppl):15-24 - PubMed
- Gen Physiol Biophys. 2012 Sep;31(3):261-70 - PubMed
- J Physiol Pharmacol. 2002 Sep;53(3):349-57 - PubMed
- J Biol Chem. 1996 Apr 12;271(15):8772-8 - PubMed
- Neuroreport. 1998 Mar 30;9(5):933-6 - PubMed
- Am J Med. 1988 Mar 11;84(3A):61-6 - PubMed
- Physiol Behav. 1996 Nov;60(5):1311-5 - PubMed
- Prog Brain Res. 2008;170:129-36 - PubMed
- Brain Res. 2014 Sep 11;1580:199-218 - PubMed
- Clin Exp Hypertens. 1997 Oct;19(7):1117-34 - PubMed
- Regul Pept. 1993 Apr 29;45(1-2):253-6 - PubMed
- J Neuroendocrinol. 2020 Jun;32(6):e12856 - PubMed
- Exp Physiol. 2007 Sep;92(5):903-11 - PubMed
- Stress. 2009 Nov;12(6):517-25 - PubMed
- J Physiol Pharmacol. 2004 Dec;55(4):725-37 - PubMed
- Br J Pharmacol. 2014 Jun;171(12):3065-76 - PubMed
- J Neuroendocrinol. 2016 Apr;28(4): - PubMed
- Neuropeptides. 2020 Jun;81:102046 - PubMed
- Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H265-74 - PubMed
- J Am Soc Nephrol. 2011 Apr;22(4):673-80 - PubMed
- Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1223-8 - PubMed
- Hum Mol Genet. 2019 May 15;28(10):1682-1693 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R982-R995 - PubMed
- Trends Neurosci. 1992 Sep;15(9):351-5 - PubMed
- Braz J Med Biol Res. 2000 Oct;33(10):1121-31 - PubMed
- Basic Res Cardiol. 2010 Mar;105(2):205-18 - PubMed
- J Comp Neurol. 1994 Mar 22;341(4):476-91 - PubMed
- Ann Nutr Metab. 2016;68 Suppl 2:19-23 - PubMed
- Kidney Int. 2009 Nov;76(10):1035-9 - PubMed
- Physiol Rep. 2017 Apr;5(8): - PubMed
- Am J Physiol Renal Physiol. 2006 Feb;290(2):F438-49 - PubMed
- Peptides. 2018 Apr;102:68-74 - PubMed
- Front Neuroendocrinol. 2002 Jan;23(1):101-35 - PubMed
- J Biol Chem. 2007 Apr 13;282(15):11255-65 - PubMed
- Pathophysiology. 2016 Jun;23(2):111-21 - PubMed
- Biochimie. 1988 Sep;70(9):1197-207 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R452-8 - PubMed
- J Auton Nerv Syst. 1999 Oct 8;78(1):49-56 - PubMed
- Brain Res. 1982 Nov 18;251(2):283-90 - PubMed
- Handb Clin Neurol. 2021;181:239-248 - PubMed
- Eur Heart J. 2021 Sep 21;42(36):3599-3726 - PubMed
- J Clin Med. 2015 May 08;4(5):933-47 - PubMed
- Am J Physiol. 1989 Aug;257(2 Pt 2):H415-22 - PubMed
- Mol Endocrinol. 2012 Mar;26(3):502-20 - PubMed
- Neurosci Lett. 2007 Jan 29;412(2):154-8 - PubMed
- Brain Res. 1985 Jul 22;339(1):126-9 - PubMed
- Can J Physiol Pharmacol. 1987 Oct;65(10):2071-5 - PubMed
- Am J Physiol Renal Physiol. 2016 Feb 15;310(4):F284-93 - PubMed
- Neurosci Lett. 2008 Aug 1;440(2):166-9 - PubMed
- Cell Tissue Res. 2019 Jan;375(1):41-48 - PubMed
- Am J Physiol Renal Physiol. 2013 Dec 1;305(11):F1547-54 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1787-97 - PubMed
- Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2262-70 - PubMed
- Am J Physiol Renal Physiol. 2021 Sep 1;321(3):F305-F321 - PubMed
- J Cereb Blood Flow Metab. 2014 May;34(5):852-60 - PubMed
- Neuro Endocrinol Lett. 2012;33(2):124-32 - PubMed
- Integr Zool. 2021 Mar;16(2):149-159 - PubMed
- Genomics. 1996 Feb 1;31(3):327-34 - PubMed
- J Cardiovasc Pharmacol. 2000 Jul;36(1):38-44 - PubMed
- J Neuroendocrinol. 2012 Apr;24(4):629-41 - PubMed
- Mol Vis. 2011;17:3254-61 - PubMed
- J Thorac Cardiovasc Surg. 2018 Dec;156(6):2098-2107 - PubMed
- Psych J. 2015 Sep;4(3):160-5 - PubMed
- Chem Sci. 2021 Feb 4;12(11):4057-4062 - PubMed
- Endocrinology. 1999 Mar;140(3):1301-9 - PubMed
- Exp Gerontol. 2011 Feb-Mar;46(2-3):90-5 - PubMed
- Clin Kidney J. 2014 Jun;7(3):242-7 - PubMed
- Front Psychiatry. 2019 May 31;10:380 - PubMed
- Prog Brain Res. 2002;139:275-9 - PubMed
- Trends Neurosci. 1996 Oct;19(10):440-4 - PubMed
- Eur J Pharmacol. 2001 Jul 6;423(2-3):195-202 - PubMed
- Neuro Endocrinol Lett. 2011;32(6):805-10 - PubMed
- Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H639-H651 - PubMed
- Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):959-65 - PubMed
- J Pharmacol Exp Ther. 1984 Feb;228(2):348-53 - PubMed
- Vitam Horm. 2005;71:27-58 - PubMed
- Peptides. 2016 Dec;86:55-62 - PubMed
- Regul Pept. 2007 Jul 5;142(1-2):29-36 - PubMed
- PLoS One. 2012;7(8):e44014 - PubMed
- Cell Tissue Res. 1978 Sep 26;192(3):423-35 - PubMed
- Braz J Med Biol Res. 2013 Apr;46(4):327-38 - PubMed
- Neuropeptides. 2016 Aug;58:61-5 - PubMed
- Kidney Int. 2010 Nov;78(9):849-56 - PubMed
- Crit Care. 2009;13(3):R98 - PubMed
- Braz J Med Biol Res. 2002 Sep;35(9):1101-9 - PubMed
- Am J Primatol. 2018 Oct;80(10):e22875 - PubMed
- Endocrinology. 2012 May;153(5):2353-61 - PubMed
- J Am Coll Cardiol. 1983 Jun;1(6):1385-90 - PubMed
- Mol Pharmacol. 2004 Mar;65(3):623-9 - PubMed
- Front Neurosci. 2016 Jan 28;9:510 - PubMed
- J Card Fail. 2018 Jul;24(7):470-478 - PubMed
- Brain Res. 1988 Dec;464(4):303-11 - PubMed
- J Intern Med. 2017 Oct;282(4):284-297 - PubMed
- Brain Res. 1998 Jan 19;781(1-2):57-61 - PubMed
- Nature. 2017 Aug 24;548(7668):420-425 - PubMed
- Physiol Rev. 2018 Jul 1;98(3):1805-1908 - PubMed
- Brain Res. 1992 Apr 3;576(2):231-4 - PubMed
- J Neuroendocrinol. 2019 Feb;31(2):e12686 - PubMed
- Neuron. 2008 Apr 24;58(2):179-85 - PubMed
- Kidney Int. 2008 Apr;73(7):811-5 - PubMed
- Hypertension. 1981 May-Jun;3(3 Pt 2):I93-100 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2021 Mar 1;320(3):R213-R225 - PubMed
- Dis Markers. 2015;2015:614145 - PubMed
- J Neuroendocrinol. 1998 Jun;10(6):453-9 - PubMed
- Front Neuroendocrinol. 2008 Jan;29(1):114-27 - PubMed
- Physiol Rev. 2004 Jan;84(1):169-208 - PubMed
- Neuropeptides. 2009 Aug;43(4):259-65 - PubMed
- Eur Surg Res. 2008;40(1):34-40 - PubMed
- Endocr Metab Immune Disord Drug Targets. 2013 Sep;13(3):250-5 - PubMed
- Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):84-94 - PubMed
- J Neuroendocrinol. 2012 Apr;24(4):554-65 - PubMed
- Respir Physiol Neurobiol. 2002 Oct 23;133(1-2):75-88 - PubMed
- Hypertension. 2005 Oct;46(4):1004-9 - PubMed
- Am J Physiol Renal Physiol. 2014 May 1;306(9):F931-40 - PubMed
- Auton Neurosci. 2002 Aug 30;99(2):85-90 - PubMed
- Biomed Res Int. 2016;2016:3652068 - PubMed
- Am J Physiol. 1994 Sep;267(3 Pt 2):R786-91 - PubMed
- Exp Brain Res. 1999 May;126(1):68-76 - PubMed
- Ann N Y Acad Sci. 1995 Dec 29;771:273-92 - PubMed
- Clin Chem. 2006 Jan;52(1):112-9 - PubMed
- Am J Physiol. 1974 Jan;226(1):155-61 - PubMed
- Brain Res. 2000 Jul 28;872(1-2):87-92 - PubMed
- J Pharmacol Sci. 2009 Jan;109(1):50-2 - PubMed
- Pflugers Arch. 1984 Mar;400(3):294-9 - PubMed
- Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14558-63 - PubMed
- Am J Physiol. 1994 Nov;267(5 Pt 2):R1217-25 - PubMed
- J Neuroendocrinol. 2020 Apr;32(4):e12826 - PubMed
- Am J Physiol. 1994 Aug;267(2 Pt 2):H751-6 - PubMed
- Neuroscience. 1989;32(2):435-9 - PubMed
- Crit Rev Neurobiol. 1996;10(1):119-54 - PubMed
- J Neuroendocrinol. 2021 May;33(5):e12972 - PubMed
- Brain Res Bull. 1985 Dec;15(6):595-601 - PubMed
Publication Types