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Pankova OV, Tashireva LA, Rodionov EO, et al. Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients. Front Oncol. 2021;11:771802doi: 10.3389/fonc.2021.771802.
Pankova, O. V., Tashireva, L. A., Rodionov, E. O., Miller, S. V., Tuzikov, S. A., Pismenny, D. S., Gerashchenko, T. S., Zavyalova, M. V., Vtorushin, S. V., Denisov, E. V., & Perelmuter, V. M. (2021). Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients. Frontiers in oncology, 11771802. https://doi.org/10.3389/fonc.2021.771802
Pankova, Olga V, et al. "Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients." Frontiers in oncology vol. 11 (2021): 771802. doi: https://doi.org/10.3389/fonc.2021.771802
Pankova OV, Tashireva LA, Rodionov EO, Miller SV, Tuzikov SA, Pismenny DS, Gerashchenko TS, Zavyalova MV, Vtorushin SV, Denisov EV, Perelmuter VM. Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients. Front Oncol. 2021 Nov 10;11:771802. doi: 10.3389/fonc.2021.771802. eCollection 2021. PMID: 34858851; PMCID: PMC8631511.
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Front Oncol. 2021 Nov 10;11:771802. doi: 10.3389/fonc.2021.771802. eCollection 2021.

Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients.

Frontiers in oncology

Olga V Pankova, Liubov A Tashireva, Evgeny O Rodionov, Sergey V Miller, Sergey A Tuzikov, Dmitry S Pismenny, Tatiana S Gerashchenko, Marina V Zavyalova, Sergey V Vtorushin, Evgeny V Denisov, Vladimir M Perelmuter

Affiliations

  1. Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia.
  2. Department of Pathological Anatomy, Siberian State Medical University State Medical University, Tomsk, Russia.
  3. Department of Organic Chemistry, Tomsk State University, Tomsk, Russia.

PMID: 34858851 PMCID: PMC8631511 DOI: 10.3389/fonc.2021.771802

Abstract

BACKGROUND: The study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer.

METHODS: In 171 patients with non-small cell lung cancer (T

RESULTS: During the follow-up period, distant metastases were found in 35.1% (60/171) of patients. Most often, they were observed in patients of the high-risk group: BCH+SM-D- (51.6%, 40/95) and BCH-SM+D+ (54.4%, 6/11). Less often, distant metastases were observed in low-risk group patients: BCH+SM+D- (6.7%, 3/45) and BCH-SM-D- (10.0%, 2/20). Tumor size, grade, and stage were significant predictors of metastasis only in the high-risk group. The 5-year metastasis-free survival was better in the low-risk group of distant metastases.

CONCLUSIONS: Isolated BCH or dysplasia in small bronchi distant from foci of tumor is associated with a high-risk distant metastasis and less 5-year metastasis-free survival.

Copyright © 2021 Pankova, Tashireva, Rodionov, Miller, Tuzikov, Pismenny, Gerashchenko, Zavyalova, Vtorushin, Denisov and Perelmuter.

Keywords: basal cell hyperplasia; bronchial lesion; distant metastasis; metastasis-free survival; non-small cell lung cancer (NSCLC); squamous cell metaplasia

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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