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Wu CH, Huang WC, Chen CH, et al. Outcomes of Hepatitis B Immunoglobulin and Hepatitis B Vaccination in High-Risk Newborns Born to HBeAg-positive Mothers. Biomed J. 2021;doi: 10.1016/j.bj.2021.11.007.
Wu, C. H., Huang, W. C., Chen, C. H., & Lu, S. N. (2021). Outcomes of Hepatitis B Immunoglobulin and Hepatitis B Vaccination in High-Risk Newborns Born to HBeAg-positive Mothers. Biomedical journal, . https://doi.org/10.1016/j.bj.2021.11.007
Wu, Chen-Hsuan, et al. "Outcomes of Hepatitis B Immunoglobulin and Hepatitis B Vaccination in High-Risk Newborns Born to HBeAg-positive Mothers." Biomedical journal vol. (2021). doi: https://doi.org/10.1016/j.bj.2021.11.007
Wu CH, Huang WC, Chen CH, Lu SN. Outcomes of Hepatitis B Immunoglobulin and Hepatitis B Vaccination in High-Risk Newborns Born to HBeAg-positive Mothers. Biomed J. 2021 Nov 18; doi: 10.1016/j.bj.2021.11.007. Epub 2021 Nov 18. PMID: 34801765.
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Biomed J. 2021 Nov 18; doi: 10.1016/j.bj.2021.11.007. Epub 2021 Nov 18.

Outcomes of Hepatitis B Immunoglobulin and Hepatitis B Vaccination in High-Risk Newborns Born to HBeAg-positive Mothers.

Biomedical journal

Chen-Hsuan Wu, Wei-Cheng Huang, Chien-Hung Chen, Sheng-Nan Lu

Affiliations

  1. Graduate Institute of Clinical Medical Sciences, Chang Gung University, College of Medicine, Kaohsiung, Taiwan; Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  2. Department of Geriatrics, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan.
  3. Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  4. Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: [email protected].

PMID: 34801765 DOI: 10.1016/j.bj.2021.11.007

Abstract

BACKGROUND: To evaluate the protective efficacy of a hepatitis B (HB) vaccination program in Taiwan among high-risk children.

MATERIAL AND METHODS: Children born to HBeAg-positive mothers from 2001 to 2010 were invited back. Blood samples for hepatitis B virus (HBV) seromarkers were taken and the children underwent hepatobiliary ultrasonography. Perinatal factors including delivery mode and vaccination history were collected from their medical records. According to the results of HBV serological markers, the children were initially classified into five groups: HBV naïve, HB vaccine responder, HBsAg carrier, recovered from HBV infection, and anti-HBc-positive alone. Children in the HBV naïve and anti-HBc-positive alone groups who presented with an anamnestic response after a booster HB vaccine were re-assigned to the vaccine responder and recovered from infection groups, respectively.

RESULTS: All of the 196 enrolled children received postnatal hepatitis B immunoglobulin (HBIG) and HB vaccinations, of whom one was HBV naïve (0.5%), 109 were vaccine responders (55.6%), 21 were carriers (10.7%), and 65 recovered from infection (33.2%). Among the 21 carriers, 14 (66.7%) presented in the immunotolerant phase. Cesarean section was the only significant perinatal factor between the carriers (5.3%) and those who recovered from infection (37.7%) (p=0.007).

CONCLUSIONS: In this study, there was a 43.9% HBV infection rate and 10.7% HBsAg carrier rate in high-risk Taiwanese children even after receiving HBIG and HB vaccinations. Cesarean section may protect newborns from becoming HBsAg carriers, while HBV genotype and time of HBIG injection did not contribute to the HBV carrier rate.

Copyright © 2021 Chang Gung University. Published by Elsevier B.V. All rights reserved.

Keywords: Hepatitis B Antibodies; Hepatitis B e Antigens; Mass Vaccination

Conflict of interest statement

Declaration of Competing Interest All authors have no conflicts of interest that could be perceived to bias their work, making known all financial support and any other personal connections.

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