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Han X, Hong X, Li X, et al. Optimization of Personalized Amlodipine Dosing Strategies for Children Based on Pharmacokinetic Data from Chinese Male Adults and PBPK Modeling. Children (Basel). 2021;8(11)doi: 10.3390/children8110950.
Han, X., Hong, X., Li, X., Wang, Y., Wang, Z., & Zheng, A. (2021). Optimization of Personalized Amlodipine Dosing Strategies for Children Based on Pharmacokinetic Data from Chinese Male Adults and PBPK Modeling. Children (Basel, Switzerland), 8(11), . https://doi.org/10.3390/children8110950
Han, Xiaolu, et al. "Optimization of Personalized Amlodipine Dosing Strategies for Children Based on Pharmacokinetic Data from Chinese Male Adults and PBPK Modeling." Children (Basel, Switzerland) vol. 8,11 (2021). doi: https://doi.org/10.3390/children8110950
Han X, Hong X, Li X, Wang Y, Wang Z, Zheng A. Optimization of Personalized Amlodipine Dosing Strategies for Children Based on Pharmacokinetic Data from Chinese Male Adults and PBPK Modeling. Children (Basel). 2021 Oct 22;8(11). doi: 10.3390/children8110950. PMID: 34828663; PMCID: PMC8618961.
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Children (Basel). 2021 Oct 22;8(11). doi: 10.3390/children8110950.

Optimization of Personalized Amlodipine Dosing Strategies for Children Based on Pharmacokinetic Data from Chinese Male Adults and PBPK Modeling.

Children (Basel, Switzerland)

Xiaolu Han, Xiaoxuan Hong, Xianfu Li, Yuxi Wang, Zengming Wang, Aiping Zheng

Affiliations

  1. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Haidian District, Beijing 100850, China.
  2. Troops 32104 of People's Liberation Army of China, Alashan League 735400, China.
  3. Shanghai PharmoGo Co., Ltd., 3F, Block B, Weitai Building, No. 58, Lane 91, Shanghai 200127, China.

PMID: 34828663 PMCID: PMC8618961 DOI: 10.3390/children8110950

Abstract

For children, a special population who are continuously developing, a reasonable dosing strategy is the key to clinical therapy. Accurate dose predictions can help maximize efficacy and minimize pain in pediatrics.

Keywords: PBPK model; amlodipine; dosage optimization; hypertension; model-informed drug development; pediatric preparations

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