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Vasilenko DA, Sadovnikov KS, Sedenkova KN, et al. A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor. Molecules. 2021;26(21)doi: 10.3390/molecules26216411.
Vasilenko, D. A., Sadovnikov, K. S., Sedenkova, K. N., Karlov, D. S., Radchenko, E. V., Grishin, Y. K., Rybakov, V. B., Kuznetsova, T. S., Zamoyski, V. L., Grigoriev, V. V., Palyulin, V. A., & Averina, E. B. (2021). A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor. Molecules (Basel, Switzerland), 26(21), . https://doi.org/10.3390/molecules26216411
Vasilenko, Dmitry A, et al. "A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor." Molecules (Basel, Switzerland) vol. 26,21 (2021). doi: https://doi.org/10.3390/molecules26216411
Vasilenko DA, Sadovnikov KS, Sedenkova KN, Karlov DS, Radchenko EV, Grishin YK, Rybakov VB, Kuznetsova TS, Zamoyski VL, Grigoriev VV, Palyulin VA, Averina EB. A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor. Molecules. 2021 Oct 23;26(21). doi: 10.3390/molecules26216411. PMID: 34770819; PMCID: PMC8588558.
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Molecules. 2021 Oct 23;26(21). doi: 10.3390/molecules26216411.

A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor.

Molecules (Basel, Switzerland)

Dmitry A Vasilenko, Kirill S Sadovnikov, Kseniya N Sedenkova, Dmitry S Karlov, Eugene V Radchenko, Yuri K Grishin, Victor B Rybakov, Tamara S Kuznetsova, Vladimir L Zamoyski, Vladimir V Grigoriev, Vladimir A Palyulin, Elena B Averina

Affiliations

  1. Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
  2. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, 142432 Moscow, Russia.

PMID: 34770819 PMCID: PMC8588558 DOI: 10.3390/molecules26216411

Abstract

A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated. It was based on the heterocyclization reactions of readily available electrophilic alkenes with the tetranitromethane-triethylamine complex. The structural diversity of the synthesized compounds was demonstrated. In the electrophysiological experiments using the patch clamp technique on Purkinje neurons, the compound 1,4-phenylenedi(methylene)bis(5-aminoisoxazole-3-carboxylate) was shown to be highly potent positive modulator of the AMPA receptor, potentiating kainate-induced currents up to 70% at 10

Keywords: AMPA receptor; PAM; bivalent ligand; heterocycles; heterocyclization; isoxazole; medicinal chemistry; tetranitromethane

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