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Liu H, Li X, Ji M, et al. Two-step fabricating micelle-like nanoparticles of cisplatin with the 'real' long circulation and high bioavailability for cancer therapy. Colloids Surf B Biointerfaces. 2021;210:112225doi: 10.1016/j.colsurfb.2021.112225.
Liu, H., Li, X., Ji, M., Wang, N., Xu, Y., Kong, Y., Gou, J., Yin, T., He, H., Zhang, Y., & Tang, X. (2021). Two-step fabricating micelle-like nanoparticles of cisplatin with the 'real' long circulation and high bioavailability for cancer therapy. Colloids and surfaces. B, Biointerfaces, 210112225. https://doi.org/10.1016/j.colsurfb.2021.112225
Liu, Hongbing, et al. "Two-step fabricating micelle-like nanoparticles of cisplatin with the 'real' long circulation and high bioavailability for cancer therapy." Colloids and surfaces. B, Biointerfaces vol. 210 (2021): 112225. doi: https://doi.org/10.1016/j.colsurfb.2021.112225
Liu H, Li X, Ji M, Wang N, Xu Y, Kong Y, Gou J, Yin T, He H, Zhang Y, Tang X. Two-step fabricating micelle-like nanoparticles of cisplatin with the 'real' long circulation and high bioavailability for cancer therapy. Colloids Surf B Biointerfaces. 2021 Nov 20;210:112225. doi: 10.1016/j.colsurfb.2021.112225. Epub 2021 Nov 20. PMID: 34861539.
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Colloids Surf B Biointerfaces. 2021 Nov 20;210:112225. doi: 10.1016/j.colsurfb.2021.112225. Epub 2021 Nov 20.

Two-step fabricating micelle-like nanoparticles of cisplatin with the 'real' long circulation and high bioavailability for cancer therapy.

Colloids and surfaces. B, Biointerfaces

Hongbing Liu, Xiaowen Li, Muse Ji, Na Wang, Ying Xu, Yihan Kong, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang

Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.
  2. School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.
  3. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. Electronic address: [email protected].

PMID: 34861539 DOI: 10.1016/j.colsurfb.2021.112225

Abstract

Cisplatin is a widely used anticancer drug for various solid tumors. However, the serious adverse effects caused by systemic distribution limit its wide use. In this study, we intend to use biocompatible materials polyethyleneimine (PEI) and poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) (PLG-g-PEG) to construct nanoparticles to enhance the efficacy of cisplatin and reduce its side effects. The micelle-like nanoparticles were fabricated by a simple two-step method, with a core consisting of PEI and cisplatin and a PLG-g-mPEG coating layer. The obtained nanoparticles have a small particle size (41.79 nm) and high drug loading (16.43%). The coated nanoparticles (NP-II) strengthened the structure of PEI and cisplatin complex (NP-I) and slowed the drug release for less than 20% at pH 7.4 PBS in 24 h. Therefore, it could effectively inhibit the binding of free drug and plasma proteins to achieve the long circulation, and the bioavailability could be increased to about 600% and 285% of cisplatin solution and NP-I respectively. Besides, the cellular uptake of NP-II was enhanced in the acidic tumor microenvironment due to the detachment of coating layer and the increase of positive zeta potential of nanoparticles, which was benefit to reduce the side effect of cisplatin to normal cells. In vivo pharmacodynamic experiments also showed that NP-II improved the efficacy and reduced side effects compared to the cisplatin solution. In conclusion, the two-step fabricating micelle-like nanoparticles with the improved therapeutic efficiency and reduced side effects show great potential for cancer chemotherapy.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Cancer chemotherapy; Cisplatin; High bioavailability; Long circulation; Micelle-like nanoparticle

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