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Dołowy M, Jampilek J, Bober-Majnusz K. A Comparative Study of the Lipophilicity of Metformin and Phenformin. Molecules. 2021;26(21)doi: 10.3390/molecules26216613.
Dołowy, M., Jampilek, J., & Bober-Majnusz, K. (2021). A Comparative Study of the Lipophilicity of Metformin and Phenformin. Molecules (Basel, Switzerland), 26(21), . https://doi.org/10.3390/molecules26216613
Dołowy, Małgorzata, et al. "A Comparative Study of the Lipophilicity of Metformin and Phenformin." Molecules (Basel, Switzerland) vol. 26,21 (2021). doi: https://doi.org/10.3390/molecules26216613
Dołowy M, Jampilek J, Bober-Majnusz K. A Comparative Study of the Lipophilicity of Metformin and Phenformin. Molecules. 2021 Oct 31;26(21). doi: 10.3390/molecules26216613. PMID: 34771022; PMCID: PMC8588420.
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Molecules. 2021 Oct 31;26(21). doi: 10.3390/molecules26216613.

A Comparative Study of the Lipophilicity of Metformin and Phenformin.

Molecules (Basel, Switzerland)

Małgorzata Dołowy, Josef Jampilek, Katarzyna Bober-Majnusz

Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellonska 4, 41-200 Sosnowiec, Poland.
  2. Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia.

PMID: 34771022 PMCID: PMC8588420 DOI: 10.3390/molecules26216613

Abstract

The results presented in this paper confirm the beneficial role of an easy-to-use and low-cost thin-layer chromatography (TLC) technique for describing the retention behavior and the experimental lipophilicity parameter of two biguanide derivatives, metformin and phenformin, in both normal-phase (NP) and reversed-phase (RP) TLC systems. The retention parameters (R

Keywords: lipophilicity; logP; metformin; phenformin; topological indices

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