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Taheri M, Barth DA, Kargl J, et al. Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function. Front Immunol. 2021;12:756042doi: 10.3389/fimmu.2021.756042.
Taheri, M., Barth, D. A., Kargl, J., Rezaei, O., Ghafouri-Fard, S., & Pichler, M. (2021). Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function. Frontiers in immunology, 12756042. https://doi.org/10.3389/fimmu.2021.756042
Taheri, Mohammad, et al. "Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function." Frontiers in immunology vol. 12 (2021): 756042. doi: https://doi.org/10.3389/fimmu.2021.756042
Taheri M, Barth DA, Kargl J, Rezaei O, Ghafouri-Fard S, Pichler M. Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function. Front Immunol. 2021 Nov 04;12:756042. doi: 10.3389/fimmu.2021.756042. eCollection 2021. PMID: 34804042; PMCID: PMC8599985.
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Front Immunol. 2021 Nov 04;12:756042. doi: 10.3389/fimmu.2021.756042. eCollection 2021.

Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function.

Frontiers in immunology

Mohammad Taheri, Dominik A Barth, Julia Kargl, Omidvar Rezaei, Soudeh Ghafouri-Fard, Martin Pichler

Affiliations

  1. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  2. Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  3. Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria.
  4. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  5. Research Unit of Non-Coding RNAs and Genome Editing in Cancer, Division of Clinical Oncology, Department of Internal Medicine, Comprehensive Cancer Center Graz, Medical University of Graz, Graz, Austria.
  6. Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

PMID: 34804042 PMCID: PMC8599985 DOI: 10.3389/fimmu.2021.756042

Abstract

T-lymphocytes (T cells) play a major role in adaptive immunity and current immune checkpoint inhibitor-based cancer treatments. The regulation of their function is complex, and in addition to cytokines, receptors and transcription factors, several non-coding RNAs (ncRNAs) have been shown to affect differentiation and function of T cells. Among these non-coding RNAs, certain small microRNAs (miRNAs) including miR-15a/16-1, miR-125b-5p, miR-99a-5p, miR-128-3p, let-7 family, miR-210, miR-182-5p, miR-181, miR-155 and miR-10a have been well recognized. Meanwhile, IFNG-AS1, lnc-ITSN1-2, lncRNA-CD160, NEAT1, MEG3, GAS5, NKILA, lnc-EGFR and PVT1 are among long non-coding RNAs (lncRNAs) that efficiently influence the function of T cells. Recent studies have underscored the effects of a number of circular RNAs, namely circ_0001806, hsa_circ_0045272, hsa_circ_0012919, hsa_circ_0005519 and circHIPK3 in the modulation of T-cell apoptosis, differentiation and secretion of cytokines. This review summarizes the latest news and regulatory roles of these ncRNAs on the function of T cells, with widespread implications on the pathophysiology of autoimmune disorders and cancer.

Copyright © 2021 Taheri, Barth, Kargl, Rezaei, Ghafouri-Fard and Pichler.

Keywords: T cell; autoimmune; cancer; circRNA; lncRNA; miRNA

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Cell Rep. 2019 Aug 20;28(8):2169-2181.e4 - PubMed
  2. Cancer Biol Ther. 2019;20(5):653-665 - PubMed
  3. Atherosclerosis. 2019 Dec;291:78-86 - PubMed
  4. Curr Genomics. 2010 Nov;11(7):537-61 - PubMed
  5. J Cell Physiol. 2019 Jul;234(7):12029-12041 - PubMed
  6. J Biol Chem. 2012 Jan 20;287(4):2608-17 - PubMed
  7. J Immunol. 2018 Oct 1;201(7):2165-2175 - PubMed
  8. Clin Exp Immunol. 2018 Feb;191(2):166-179 - PubMed
  9. Int Rev Immunol. 2019;38(5):232-245 - PubMed
  10. Immunol Cell Biol. 2021 Mar;99(3):323-332 - PubMed
  11. RNA Biol. 2015;12(4):381-8 - PubMed
  12. Exp Ther Med. 2018 Nov;16(5):4246-4252 - PubMed
  13. Biochem Pharmacol. 2020 Apr;174:113822 - PubMed
  14. Cell Signal. 2019 Jul;59:182-190 - PubMed
  15. J Leukoc Biol. 2018 May;103(5):855-866 - PubMed
  16. Cell. 2014 Aug 14;158(4):749-763 - PubMed
  17. Clin Immunol. 2017 Oct;183:121-131 - PubMed
  18. Mucosal Immunol. 2020 Mar;13(2):303-312 - PubMed
  19. Nat Commun. 2019 Dec 13;10(1):5697 - PubMed
  20. Chemistry. 2010 Jan 25;16(4):1186-92 - PubMed
  21. J Immunol. 2018 Mar 1;200(5):1618-1626 - PubMed
  22. Clin Exp Allergy. 2019 Aug;49(8):1116-1127 - PubMed
  23. Biosci Rep. 2019 Sep 20;39(9): - PubMed
  24. Oncol Lett. 2020 Jul;20(1):235-247 - PubMed
  25. Int J Mol Med. 2020 Aug;46(2):859-868 - PubMed
  26. Life Sci. 2020 Oct 15;259:118218 - PubMed
  27. Nat Immunol. 2013 Apr;14(4):404-12 - PubMed
  28. Biomed Pharmacother. 2019 Mar;111:386-394 - PubMed
  29. Biosci Rep. 2018 Jul 31;38(4): - PubMed
  30. Clin Cancer Res. 2017 Mar 1;23(5):1323-1333 - PubMed
  31. Biochem Biophys Res Commun. 2020 Aug 27;529(3):784-792 - PubMed
  32. Lupus. 2020 Jun;29(7):727-734 - PubMed
  33. Cell Biosci. 2020 Feb 12;10:15 - PubMed
  34. Cancers (Basel). 2019 Dec 12;11(12): - PubMed
  35. FASEB J. 2018 Nov;32(11):5967-5975 - PubMed
  36. Hepatology. 2018 Mar;67(3):1027-1040 - PubMed
  37. Int J Mol Sci. 2019 Feb 01;20(3): - PubMed
  38. Biomed Pharmacother. 2019 Mar;111:51-59 - PubMed
  39. Nat Commun. 2017 May 25;8:15129 - PubMed
  40. Cell Mol Immunol. 2019 Feb;16(2):112-125 - PubMed
  41. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11916-11925 - PubMed
  42. J Autoimmun. 2020 Feb;107:102358 - PubMed
  43. Arch Biochem Biophys. 2020 Nov 30;695:108611 - PubMed
  44. Aging (Albany NY). 2019 Jul 15;11(13):4463-4477 - PubMed
  45. J Mol Med (Berl). 2020 Feb;98(2):309-320 - PubMed
  46. Int Immunopharmacol. 2019 Oct;75:105778 - PubMed
  47. Br J Cancer. 2015 Aug 11;113(4):569-73 - PubMed
  48. Cell Death Dis. 2019 Jan 18;10(2):46 - PubMed
  49. Cell Mol Neurobiol. 2021 May;41(4):619-649 - PubMed
  50. Cell Physiol Biochem. 2018;49(2):828-836 - PubMed
  51. Mol Cell Biochem. 2019 Apr;454(1-2):67-76 - PubMed
  52. Front Immunol. 2020 May 28;11:852 - PubMed
  53. Biochem J. 2012 Jan 1;441(1):1-21 - PubMed
  54. Sci Immunol. 2018 May 4;3(23): - PubMed
  55. Cell Death Dis. 2020 Apr 2;11(4):216 - PubMed
  56. FEBS J. 2017 Jul;284(13):1952-1966 - PubMed
  57. Front Immunol. 2018 Oct 29;9:2512 - PubMed
  58. Oncogene. 2015 Sep 24;34(39):5003-11 - PubMed
  59. Onco Targets Ther. 2019 Nov 07;12:9407-9419 - PubMed
  60. World J Pediatr. 2020 Feb;16(1):99-110 - PubMed
  61. Cytokine. 2015 Jul;74(1):5-17 - PubMed
  62. Mol Med Rep. 2019 Oct;20(4):3617-3624 - PubMed
  63. Biochem Biophys Res Commun. 2018 Feb 5;496(2):352-358 - PubMed
  64. J Cell Physiol. 2019 Dec;234(12):22477-22484 - PubMed
  65. Mol Immunol. 2020 Sep;125:32-42 - PubMed
  66. J Clin Invest. 2018 Jun 1;128(6):2551-2568 - PubMed
  67. Front Immunol. 2018 Nov 27;9:2754 - PubMed
  68. Pediatr Allergy Immunol. 2019 Jun;30(4):434-442 - PubMed
  69. Clin Immunol. 2014 Jul;153(1):73-8 - PubMed
  70. Transpl Immunol. 2020 Oct;62:101320 - PubMed
  71. Immunology. 2018 Sep;155(1):137-149 - PubMed
  72. Arch Oral Biol. 2019 Mar;99:126-133 - PubMed
  73. Development. 2016 Sep 1;143(17):3050-60 - PubMed
  74. FASEB J. 2017 Feb;31(2):519-525 - PubMed
  75. Trends Cell Biol. 2012 Nov;22(11):557-66 - PubMed
  76. Nat Rev Immunol. 2009 Feb;9(2):125-35 - PubMed
  77. Biomed Pharmacother. 2019 Oct;118:109129 - PubMed
  78. Front Immunol. 2019 Jun 13;10:1367 - PubMed
  79. Int J Mol Sci. 2016 Apr 15;17(4):573 - PubMed
  80. J Immunol. 2018 Jun 15;200(12):4170-4179 - PubMed
  81. Clin Epigenetics. 2021 Jan 6;13(1):1 - PubMed
  82. Cell. 2011 Aug 5;146(3):353-8 - PubMed
  83. Int Immunopharmacol. 2020 Nov;88:106992 - PubMed
  84. J Autoimmun. 2019 Jan;96:94-103 - PubMed
  85. Cancer Lett. 2015 Jun 28;362(1):45-60 - PubMed
  86. Blood. 2018 Apr 26;131(17):1974-1986 - PubMed
  87. Front Immunol. 2021 Mar 12;12:601298 - PubMed
  88. Nature. 1998 Jan 22;391(6665):410-3 - PubMed
  89. Nat Rev Immunol. 2003 Nov;3(11):900-11 - PubMed
  90. Nat Immunol. 2014 Apr;15(4):393-401 - PubMed
  91. Mol Immunol. 2021 Jun;134:202-209 - PubMed
  92. Int Immunopharmacol. 2019 Oct;75:105761 - PubMed
  93. Nat Immunol. 2018 Oct;19(10):1112-1125 - PubMed
  94. Parasit Vectors. 2021 Jun 3;14(1):295 - PubMed
  95. In Vitro Cell Dev Biol Anim. 2020 Jan;56(1):67-74 - PubMed
  96. Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83 - PubMed
  97. Neuroimmunomodulation. 2019;26(1):7-18 - PubMed
  98. Immunol Rev. 2011 May;241(1):260-8 - PubMed
  99. Mol Med Rep. 2021 Jan;23(1): - PubMed
  100. FASEB J. 2019 Dec;33(12):13951-13965 - PubMed
  101. Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034 - PubMed
  102. Cell Death Dis. 2018 Feb 19;9(3):290 - PubMed
  103. Eur J Immunol. 2020 Jul;50(7):944-948 - PubMed
  104. Eur Rev Med Pharmacol Sci. 2019 Mar;23(6):2486-2496 - PubMed
  105. Clin Sci (Lond). 2018 Nov 2;132(21):2285-2298 - PubMed
  106. Genomics Proteomics Bioinformatics. 2016 Feb;14(1):42-54 - PubMed
  107. Int J Mol Med. 2017 Jun;39(6):1338-1346 - PubMed
  108. J Immunol. 2015 Jan 1;194(1):21-7 - PubMed
  109. J Neuroimmune Pharmacol. 2014 Dec;9(5):629-41 - PubMed
  110. Front Microbiol. 2020 Nov 13;11:596440 - PubMed
  111. Biosci Rep. 2020 Feb 28;40(2): - PubMed
  112. Cancers (Basel). 2016 Mar 15;8(3): - PubMed
  113. Am J Cancer Res. 2016 Jun 01;6(6):1167-76 - PubMed
  114. Am J Physiol Gastrointest Liver Physiol. 2020 Jan 1;318(1):G34-G40 - PubMed
  115. Mol Oncol. 2019 Jan;13(1):46-60 - PubMed
  116. IUBMB Life. 2019 Jul;71(7):956-968 - PubMed
  117. Int J Biol Macromol. 2020 Mar 15;147:1248-1254 - PubMed
  118. FEBS Open Bio. 2018 Feb 21;8(4):544-555 - PubMed
  119. Int Immunopharmacol. 2020 Nov;88:106891 - PubMed
  120. Biomed Pharmacother. 2018 May;101:195-200 - PubMed
  121. Neoplasma. 2019 Jun 29;66(6):939-945 - PubMed

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