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Fava VAR, Sarin LM, Lucchese AC, et al. The probability of response after each subcutaneous injection of esketamine in treatment-resistant depression. Rev Psiquiatr Salud Ment (Engl Ed). 2021;14(4):212-217doi: 10.1016/j.rpsmen.2021.11.003.
Fava, V. A. R., Sarin, L. M., Lucchese, A. C., Del Sant, L., Magalhães, E., Delfino, R. S., Tuena, M. A., Nakahira, C., Jackowski, A. P., Abdo, G., Surjan, J., Steiglich, M., Barbosa, M. G., Porto, J. A. D., Lacerda, A. L. T., & Cogo-Moreira, H. (2021). The probability of response after each subcutaneous injection of esketamine in treatment-resistant depression. Revista de psiquiatria y salud mental, 14(4), 212-217. https://doi.org/10.1016/j.rpsmen.2021.11.003
Fava, Victor Augusto Rodovalho, et al. "The probability of response after each subcutaneous injection of esketamine in treatment-resistant depression." Revista de psiquiatria y salud mental vol. 14,4 (2021): 212-217. doi: https://doi.org/10.1016/j.rpsmen.2021.11.003
Fava VAR, Sarin LM, Lucchese AC, Del Sant L, Magalhães E, Delfino RS, Tuena MA, Nakahira C, Jackowski AP, Abdo G, Surjan J, Steiglich M, Barbosa MG, Porto JAD, Lacerda ALT, Cogo-Moreira H. The probability of response after each subcutaneous injection of esketamine in treatment-resistant depression. Rev Psiquiatr Salud Ment (Engl Ed). 2021 Oct-Dec;14(4):212-217. doi: 10.1016/j.rpsmen.2021.11.003. PMID: 34861929.
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Rev Psiquiatr Salud Ment (Engl Ed). 2021 Oct-Dec;14(4):212-217. doi: 10.1016/j.rpsmen.2021.11.003.

The probability of response after each subcutaneous injection of esketamine in treatment-resistant depression.

Revista de psiquiatria y salud mental

Victor Augusto Rodovalho Fava, Luciana Maria Sarin, Ana Cecília Lucchese, Lorena Del Sant, Eduardo Magalhães, Rodrigo Simonini Delfino, Marco Aurélio Tuena, Carolina Nakahira, Andrea Parolin Jackowski, Guilherme Abdo, Juliana Surjan, Matheus Steiglich, Matheus Ghossain Barbosa, José Alberto Del Porto, Acioly Luiz Tavares Lacerda, Hugo Cogo-Moreira

Affiliations

  1. Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil.
  2. Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil; Centro Alfa de Humanização, Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, Brazil.
  3. Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil; PRODAF - Programa de Transtornos Afetivos, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil.
  4. LiNC - Laboratory of Integrative Neuroscience, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil.
  5. Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil; PRODAF - Programa de Transtornos Afetivos, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil; LiNC - Laboratory of Integrative Neuroscience, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil.
  6. Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil; School of Public Health, University of Hong Kong, Hong Kong, SAR, China. Electronic address: [email protected].

PMID: 34861929 DOI: 10.1016/j.rpsmen.2021.11.003

Abstract

INTRODUCTION: The administration of multiple esketamine doses has shown efficacy for unipolar and bipolar treatment-resistant depression (TRD). Nevertheless, the probability of responding or not after each dose in the real-world remains unknown. This study aimed to estimate it throughout four doses of esketamine, administrated via subcutaneous (SC).

MATERIAL AND METHODS: We conducted a retrospective analysis of a case series of 70 patients with TRD who received treatment from the esketamine assistance program at Federal University of Sao Paulo, between April 2017 and December 2018. The SC injections were administrated weekly at a dose of 0.5-1.0mg/kg, in conjunction with patients' psychotropic drugs. Response was defined as a decrease of at least 50% in the Montgomery-Åsberg Depression Rating Scale between baseline and 24h after dose. We used hidden Markov modeling in order to estimate de probability of response after each esketamine injection.

RESULTS: The probability of a patient that was a "non-responder" to become a "responder" following a SC injection of esketamine was 17.30% and the probability that this patient remains a "non-responder" was 82.70%. The probability of a patient that was a "responder" to remain as a "responder" was 95%.

CONCLUSIONS: Patients with TRD who had not responded after the first dose of esketamine, still had a chance of responding after the subsequent dose administrated via SC.

Copyright © 2021. Published by Elsevier España, S.L.U.

Keywords: Análisis de transición latente; Bipolar depression; Depresión bipolar; Depresión resistente al tratamiento; Esketamina; Esketamine; Latent transition analysis; Respuesta al tratamiento; Treatment response; Treatment-resistant depression

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