Display options
Cite
Malekmohammadi S, Sedghi Aminabad N, Sabzi A, et al. Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications. Biomedicines. 2021;9(11)doi: 10.3390/biomedicines9111537.
Malekmohammadi, S., Sedghi Aminabad, N., Sabzi, A., Zarebkohan, A., Razavi, M., Vosough, M., Bodaghi, M., & Maleki, H. (2021). Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications. Biomedicines, 9(11), . https://doi.org/10.3390/biomedicines9111537
Malekmohammadi, Samira, et al. "Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications." Biomedicines vol. 9,11 (2021). doi: https://doi.org/10.3390/biomedicines9111537
Malekmohammadi S, Sedghi Aminabad N, Sabzi A, Zarebkohan A, Razavi M, Vosough M, Bodaghi M, Maleki H. Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications. Biomedicines. 2021 Oct 26;9(11). doi: 10.3390/biomedicines9111537. PMID: 34829766; PMCID: PMC8615087.
Copy Download .nbib Format: NLM
Share it on

Biomedicines. 2021 Oct 26;9(11). doi: 10.3390/biomedicines9111537.

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications.

Biomedicines

Samira Malekmohammadi, Negar Sedghi Aminabad, Amin Sabzi, Amir Zarebkohan, Mehdi Razavi, Massoud Vosough, Mahdi Bodaghi, Hajar Maleki

Affiliations

  1. Department of Engineering, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.
  2. Department of Regenerative Medicine, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 1665659911, Iran.
  3. Nanomedicine Research Association (NRA), Universal Scientific Education and Research Network (USERN), Tehran 1419733151, Iran.
  4. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 5166653431, Iran.
  5. Biionix Cluster, Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
  6. Department of Chemistry, Institute of Inorganic Chemistry, University of Cologne, 50939 Cologne, Germany.

PMID: 34829766 PMCID: PMC8615087 DOI: 10.3390/biomedicines9111537

Abstract

In recent years, smart/stimuli-responsive hydrogels have drawn tremendous attention for their varied applications, mainly in the biomedical field. These hydrogels are derived from different natural and synthetic polymers but are also composite with various organic and nano-organic fillers. The basic functions of smart hydrogels rely on their ability to change behavior; functions include mechanical, swelling, shaping, hydrophilicity, and bioactivity in response to external stimuli such as temperature, pH, magnetic field, electromagnetic radiation, and biological molecules. Depending on the final applications, smart hydrogels can be processed in different geometries and modalities to meet the complicated situations in biological media, namely, injectable hydrogels (following the sol-gel transition), colloidal nano and microgels, and three dimensional (3D) printed gel constructs. In recent decades smart hydrogels have opened a new horizon for scientists to fabricate biomimetic customized biomaterials for tissue engineering, cancer therapy, wound dressing, soft robotic actuators, and controlled release of bioactive substances/drugs. Remarkably, 4D bioprinting, a newly emerged technology/concept, aims to rationally design 3D patterned biological matrices from synthesized hydrogel-based inks with the ability to change structure under stimuli. This technology has enlarged the applicability of engineered smart hydrogels and hydrogel composites in biomedical fields. This paper aims to review stimuli-responsive hydrogels according to the kinds of external changes and t recent applications in biomedical and 4D bioprinting.

Keywords: 3D and 4D printing; drug delivery; nanoelectronics; stimuli-responsive hydrogels; tissue engineering; wound dressing

References

  1. J Control Release. 2017 Oct 28;264:192-202 - PubMed
  2. J Am Chem Soc. 2004 Dec 15;126(49):15938-9 - PubMed
  3. Adv Mater. 2017 Jun;29(24): - PubMed
  4. J R Soc Interface. 2015 Sep 6;12(110):0598 - PubMed
  5. Sci Transl Med. 2012 Jul 4;4(141):141ra93 - PubMed
  6. J Biomed Mater Res A. 2016 Apr;104(4):1002-16 - PubMed
  7. Adv Drug Deliv Rev. 1998 May 4;31(3):197-221 - PubMed
  8. Biomacromolecules. 2017 Nov 13;18(11):3802-3811 - PubMed
  9. Sci Rep. 2021 Jan 12;11(1):650 - PubMed
  10. ACS Appl Mater Interfaces. 2019 Jul 10;11(27):24523-24532 - PubMed
  11. Angew Chem Int Ed Engl. 2009;48(20):3584-96 - PubMed
  12. Science. 2001 Nov 23;294(5547):1708-12 - PubMed
  13. Theranostics. 2019 Aug 14;9(21):6112-6128 - PubMed
  14. J Mater Chem B. 2021 Feb 15;9(5):1238-1258 - PubMed
  15. Int J Hyperthermia. 2002 Jul-Aug;18(4):267-84 - PubMed
  16. Chemistry. 2015 Jan 12;21(3):1302-11 - PubMed
  17. Acta Biomater. 2010 Mar;6(3):1039-46 - PubMed
  18. Int J Pharm. 2014 Sep 10;472(1-2):262-75 - PubMed
  19. Biomaterials. 2003 Nov;24(24):4337-51 - PubMed
  20. Chem Rev. 2017 Aug 9;117(15):10212-10290 - PubMed
  21. ACS Appl Mater Interfaces. 2017 Sep 13;9(36):30318-30328 - PubMed
  22. Macromol Biosci. 2007 Jan 5;7(1):23-39 - PubMed
  23. ACS Appl Mater Interfaces. 2019 Feb 27;11(8):8492-8498 - PubMed
  24. Biomaterials. 2009 Oct;30(30):5950-8 - PubMed
  25. ACS Nano. 2021 Jun 16;: - PubMed
  26. Mater Sci Eng C Mater Biol Appl. 2018 Mar 1;84:44-51 - PubMed
  27. Adv Mater. 2018 Aug;30(35):e1801541 - PubMed
  28. Nat Chem. 2018 Feb;10(2):132-138 - PubMed
  29. Appl Microbiol Biotechnol. 2010 Jul;87(4):1209-20 - PubMed
  30. Biomaterials. 2005 Sep;26(27):5474-91 - PubMed
  31. Int J Pharm. 2019 Mar 25;559:299-311 - PubMed
  32. Colloids Surf B Biointerfaces. 2014 Oct 1;122:674-683 - PubMed
  33. J Tissue Eng Regen Med. 2007 Jul-Aug;1(4):245-60 - PubMed
  34. Des Monomers Polym. 2017 Sep 13;20(1):485-495 - PubMed
  35. Nanoscale. 2020 Feb 27;12(8):5186-5195 - PubMed
  36. Invest Radiol. 2002 Oct;37(10):580-6 - PubMed
  37. Curr Opin Neurobiol. 2005 Feb;15(1):116-20 - PubMed
  38. ACS Appl Bio Mater. 2020 Jan 21;3(1):693-703 - PubMed
  39. Polymers (Basel). 2020 Jul 11;12(7): - PubMed
  40. Nat Commun. 2012 Jan 03;3:603 - PubMed
  41. Nature. 2010 Jan 21;463(7279):339-43 - PubMed
  42. Nature. 2003 May 22;423(6938):439-43 - PubMed
  43. Exp Biol Med (Maywood). 2016 May;241(9):972-9 - PubMed
  44. ACS Appl Mater Interfaces. 2020 Dec 9;12(49):55290-55298 - PubMed
  45. Biomacromolecules. 2001 Summer;2(2):442-9 - PubMed
  46. Biomaterials. 2015 Dec;73:254-71 - PubMed
  47. Molecules. 2008 Nov 06;13(11):2758-85 - PubMed
  48. Curr Med Chem Anticancer Agents. 2002 Mar;2(2):267-310 - PubMed
  49. Biotechnol Adv. 2016 Jul-Aug;34(4):422-434 - PubMed
  50. Adv Mater. 2021 May;33(19):e2003387 - PubMed
  51. Biomaterials. 2006 Feb;27(6):905-16 - PubMed
  52. J Pharm Sci. 1994 Apr;83(4):601-6 - PubMed
  53. ACS Omega. 2017 Jul 31;2(7):3399-3405 - PubMed
  54. Tissue Eng. 2004 Mar-Apr;10(3-4):515-22 - PubMed
  55. Front Bioeng Biotechnol. 2019 Jul 09;7:164 - PubMed
  56. Front Chem. 2020 Jan 31;8:19 - PubMed
  57. Biomaterials. 1998 May;19(10):953-60 - PubMed
  58. Int J Biochem Cell Biol. 2016 Aug;77(Pt A):91-101 - PubMed
  59. Stem Cells. 2010 Apr;28(4):775-87 - PubMed
  60. Int J Biol Macromol. 2018 Apr 15;110:17-29 - PubMed
  61. Nature. 2016 Dec 14;540(7633):371-378 - PubMed
  62. Nat Rev Mater. 2016;1: - PubMed
  63. Adv Mater. 2016 Dec;28(45):9993-9999 - PubMed
  64. Adv Healthc Mater. 2017 Oct;6(19): - PubMed
  65. iScience. 2021 Jan 20;24(2):102085 - PubMed
  66. Angew Chem Int Ed Engl. 2011 Jun 6;50(24):5438-66 - PubMed
  67. Biomacromolecules. 2013 Aug 12;14(8):2733-8 - PubMed
  68. Commun Biol. 2020 Jun 17;3(1):313 - PubMed
  69. Adv Mater. 2017 Dec;29(46): - PubMed
  70. Nat Mater. 2016 Feb;15(2):190-6 - PubMed
  71. Macromol Rapid Commun. 2011 Aug 17;32(16):1253-8 - PubMed
  72. Materials (Basel). 2021 Jul 14;14(14): - PubMed
  73. Small. 2018 Jul 6;:e1703509 - PubMed
  74. Tissue Eng Part C Methods. 2016 Apr;22(4):398-407 - PubMed
  75. Matrix Biol. 2019 May;78-79:337-345 - PubMed
  76. Adv Healthc Mater. 2013 Jun;2(6):895-907 - PubMed
  77. Polymers (Basel). 2020 Aug 10;12(8): - PubMed
  78. Nanoscale. 2020 Jan 23;12(3):1224-1246 - PubMed
  79. Chem Soc Rev. 2012 Apr 7;41(7):2943-70 - PubMed
  80. Adv Mater. 2017 Jul;29(26): - PubMed
  81. Mater Today (Kidlington). 2017 Dec;20(10):577-591 - PubMed
  82. Biomaterials. 2010 Aug;31(24):6121-30 - PubMed
  83. Chem Soc Rev. 2018 Aug 28;47(17):6486-6504 - PubMed
  84. Acta Biomater. 2016 Feb;31:17-32 - PubMed
  85. Gels. 2016 Oct 14;2(4): - PubMed
  86. Biomater Res. 2016 Apr 25;20:12 - PubMed
  87. Nat Commun. 2019 Mar 29;10(1):1439 - PubMed
  88. J Control Release. 2017 May 10;253:46-63 - PubMed
  89. ACS Appl Mater Interfaces. 2017 Jan 11;9(1):876-883 - PubMed
  90. Int J Nanomedicine. 2020 Jun 25;15:4541-4572 - PubMed
  91. Macromol Rapid Commun. 2017 Jul;38(13): - PubMed
  92. Annu Rev Biochem. 2009;78:929-58 - PubMed
  93. J Biomed Mater Res A. 2018 Apr;106(4):1104-1110 - PubMed
  94. Expert Opin Drug Deliv. 2016 Sep;13(9):1257-75 - PubMed
  95. ACS Appl Mater Interfaces. 2017 Aug 9;9(31):26429-26437 - PubMed
  96. Small. 2018 Feb;14(7): - PubMed
  97. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Oct;25(5):1121-5 - PubMed
  98. Nature. 2012 Sep 6;489(7414):133-6 - PubMed
  99. Adv Mater. 2016 Jun;28(24):4884-90 - PubMed
  100. Biochem J. 1993 Aug 1;293 ( Pt 3):849-58 - PubMed
  101. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6419-23 - PubMed
  102. Mater Sci Eng R Rep. 2015 Jul;93:1-49 - PubMed
  103. Adv Healthc Mater. 2021 May;10(9):e2001876 - PubMed
  104. Carbohydr Polym. 2020 Oct 1;245:116496 - PubMed
  105. Drug Discov Today. 2005 Nov 1;10(21):1451-8 - PubMed
  106. Mater Horiz. 2017 Nov 1;4(6):1064-1069 - PubMed
  107. Science. 2019 Feb 1;363(6426):504-508 - PubMed
  108. Biomacromolecules. 2010 May 10;11(5):1387-97 - PubMed
  109. J Control Release. 1998 Dec 4;56(1-3):117-26 - PubMed
  110. Cell Stem Cell. 2009 Jul 2;5(1):17-26 - PubMed
  111. Adv Mater. 2016 Oct;28(38):8419-8424 - PubMed
  112. Nat Nanotechnol. 2018 Feb;13(2):165-172 - PubMed
  113. Biochim Biophys Acta. 2014 Aug;1840(8):2506-19 - PubMed
  114. J Biomed Mater Res A. 2015 Mar;103(3):1276-90 - PubMed
  115. Prog Biomater. 2016 Dec;5(3-4):193-198 - PubMed
  116. Sci Rep. 2015 Mar 11;5:8936 - PubMed
  117. Science. 2010 Jul 30;329(5991):528-31 - PubMed
  118. Nat Chem. 2011 Jan;3(1):34-7 - PubMed
  119. Trends Biotechnol. 2016 Sep;34(9):746-756 - PubMed
  120. Nat Commun. 2012;3:1269 - PubMed
  121. Biotechnol Bioeng. 2014 Mar;111(3):441-53 - PubMed
  122. Semin Cancer Biol. 2009 Oct;19(5):329-37 - PubMed
  123. PLoS One. 2014 Nov 12;9(11):e112888 - PubMed
  124. Biomaterials. 2001 May;22(10):1077-84 - PubMed
  125. Nat Commun. 2012 Apr 24;3:792 - PubMed
  126. Burns Trauma. 2018 Jan 23;6:5 - PubMed
  127. Acta Biomater. 2014 Apr;10(4):1612-26 - PubMed
  128. Prog Biomater. 2018 Sep;7(3):175-205 - PubMed
  129. Acta Biomater. 2015 Mar;14:11-21 - PubMed
  130. Biofabrication. 2020 Mar 23;12(2):025030 - PubMed
  131. Polymers (Basel). 2020 Apr 09;12(4): - PubMed
  132. Nat Protoc. 2016 May;11(5):920-36 - PubMed
  133. Carbohydr Polym. 2018 May 1;187:66-84 - PubMed
  134. Sci Transl Med. 2017 Dec 6;9(419): - PubMed
  135. Nat Commun. 2020 Feb 14;11(1):893 - PubMed
  136. J Mater Chem B. 2019 Mar 14;7(10):1597-1624 - PubMed
  137. ACS Nano. 2019 Sep 24;13(9):10074-10084 - PubMed
  138. Biodes Manuf. 2021 Jan 4;:1-35 - PubMed
  139. ACS Biomater Sci Eng. 2016 Jun 13;2(6):1030-1038 - PubMed
  140. Biomater Sci. 2019 Mar 26;7(4):1276-1280 - PubMed
  141. Biomaterials. 2018 Jun;168:38-53 - PubMed
  142. Acta Biomater. 2009 Nov;5(9):3358-70 - PubMed
  143. Small. 2012 Jun 11;8(11):1633-42 - PubMed
  144. Biomaterials. 2002 Nov;23(22):4325-32 - PubMed
  145. ACS Cent Sci. 2019 Mar 27;5(3):440-450 - PubMed
  146. News Physiol Sci. 2002 Feb;17:1-5 - PubMed
  147. Cell. 2006 Aug 25;126(4):677-89 - PubMed
  148. Drug Discov Today. 2018 Aug;23(8):1547-1555 - PubMed
  149. Adv Mater. 2013 Aug 14;25(30):4171-6 - PubMed
  150. Appl Phys Rev. 2018 Dec;5(4): - PubMed
  151. J Pharm Sci. 1994 Oct;83(10):1495-9 - PubMed
  152. ACS Appl Mater Interfaces. 2021 May 5;13(17):20581-20588 - PubMed
  153. Int J Nanomedicine. 2020 Jun 02;15:3887-3901 - PubMed
  154. Adv Healthc Mater. 2018 Sep;7(17):e1800412 - PubMed
  155. Sci Rep. 2016 Feb 29;6:22431 - PubMed
  156. Sci Adv. 2017 Apr 12;3(4):e1602890 - PubMed
  157. J Tissue Eng Regen Med. 2017 May;11(5):1574-1587 - PubMed
  158. Eur J Pharm Biopharm. 2018 Oct;131:189-202 - PubMed
  159. Mater Sci Eng C Mater Biol Appl. 2021 Mar;122:111914 - PubMed
  160. Adv Exp Med Biol. 2018;1077:421-449 - PubMed
  161. Science. 2018 Dec 14;362(6420):1281-1285 - PubMed
  162. Biomater Res. 2019 Dec 18;23:26 - PubMed
  163. Nature. 1999 Jun 24;399(6738):766-9 - PubMed
  164. Nat Prod Rep. 2002 Jun;19(3):312-31 - PubMed
  165. Front Cell Dev Biol. 2021 Aug 06;9:701525 - PubMed
  166. NMR Biomed. 2016 Mar;29(3):309-19 - PubMed
  167. Adv Sci (Weinh). 2020 Jun 29;7(16):2001000 - PubMed
  168. Adv Mater. 2016 Aug;28(31):6740-5 - PubMed
  169. Sci Adv. 2021 Jan 6;7(2): - PubMed
  170. Polym Adv Technol. 2008 Apr 28;19(6):647-657 - PubMed
  171. Expert Opin Drug Deliv. 2018 Jan;15(1):77-91 - PubMed
  172. Dent Mater. 2016 Jan;32(1):54-64 - PubMed
  173. Adv Healthc Mater. 2021 Jun;10(11):e2100036 - PubMed
  174. Anal Chem. 2010 May 1;82(9):3803-11 - PubMed
  175. Expert Rev Med Devices. 2007 Mar;4(2):147-64 - PubMed
  176. Int J Pharm. 2009 Oct 20;381(1):1-18 - PubMed
  177. Sci Rep. 2016 Aug 08;6:31110 - PubMed
  178. ACS Appl Mater Interfaces. 2018 Feb 28;10(8):7381-7388 - PubMed
  179. Adv Exp Med Biol. 2018;1059:353-371 - PubMed
  180. Adv Funct Mater. 2018 Dec 27;28(52): - PubMed
  181. Adv Mater. 2020 Feb;32(6):e1905901 - PubMed
  182. Biomaterials. 2014 Jan;35(1):49-62 - PubMed
  183. Small. 2021 Feb;17(5):e2005743 - PubMed
  184. Biomaterials. 2013 Nov;34(33):8042-8 - PubMed
  185. Bioengineering (Basel). 2021 Jun 08;8(6): - PubMed
  186. Nat Commun. 2011 Oct 25;2:511 - PubMed
  187. Science. 2009 Nov 27;326(5957):1216-9 - PubMed
  188. Biomacromolecules. 2011 May 9;12(5):1831-8 - PubMed
  189. Biomaterials. 2015 Aug;61:203-15 - PubMed
  190. Nat Mater. 2016 Apr;15(4):413-8 - PubMed
  191. Nat Rev Mol Cell Biol. 2010 Jan;11(1):50-61 - PubMed
  192. Eur J Pharm Biopharm. 2016 Nov;108:196-213 - PubMed
  193. Biomaterials. 2004 Jul;25(16):3187-99 - PubMed
  194. Nat Commun. 2016 Jun 27;7:12028 - PubMed
  195. J Cell Sci. 2010 Dec 15;123(Pt 24):4195-200 - PubMed
  196. ACS Appl Mater Interfaces. 2019 Nov 20;11(46):43641-43648 - PubMed
  197. J Mol Biol. 1974 Dec 5;90(2):269-84 - PubMed
  198. Nanomedicine. 2009 Sep;5(3):345-51 - PubMed
  199. Biofabrication. 2019 May 07;11(3):035018 - PubMed
  200. Int J Biochem Cell Biol. 2009 Feb;41(2):341-8 - PubMed
  201. EMBO J. 1984 Jul;3(7):1463-8 - PubMed
  202. ACS Appl Mater Interfaces. 2020 Sep 30;12(39):43911-43920 - PubMed
  203. J Med Chem. 2020 Aug 13;63(15):8003-8024 - PubMed
  204. J Control Release. 2006 Aug 10;114(1):1-14 - PubMed
  205. Trends Biotechnol. 2015 Jun;33(6):362-9 - PubMed
  206. J Control Release. 2005 Dec 5;109(1-3):256-74 - PubMed
  207. Nat Commun. 2020 Jul 31;11(1):3859 - PubMed
  208. Bioact Mater. 2020 Jun 22;5(4):808-818 - PubMed
  209. Tissue Eng Part A. 2012 Jun;18(11-12):1304-12 - PubMed
  210. Sci Adv. 2019 Aug 02;5(8):eaax6946 - PubMed
  211. ACS Biomater Sci Eng. 2020 Jul 13;6(7):3745-3761 - PubMed
  212. Macromol Biosci. 2019 May;19(5):e1800441 - PubMed
  213. Biofabrication. 2012 Sep;4(3):035005 - PubMed
  214. J Biomater Sci Polym Ed. 2021 Apr;32(6):714-734 - PubMed
  215. Chem Sci. 2016 Nov 1;7(11):6715-6720 - PubMed
  216. Biomaterials. 2017 Jan;112:133-140 - PubMed
  217. Adv Wound Care (New Rochelle). 2018 May 1;7(5):145-155 - PubMed
  218. Science. 2020 Oct 9;370(6513): - PubMed
  219. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5133-8 - PubMed
  220. Soft Matter. 2019 Jun 5;15(22):4508-4517 - PubMed
  221. Adv Colloid Interface Sci. 2017 Nov;249:192-212 - PubMed
  222. Int J Pharm. 2017 Aug 30;529(1-2):285-293 - PubMed
  223. Adv Healthc Mater. 2019 Jan;8(1):e1800465 - PubMed
  224. Biomaterials. 2002 Nov;23(22):4307-14 - PubMed
  225. Trends Pharmacol Sci. 2018 May;39(5):440-451 - PubMed
  226. Adv Healthc Mater. 2013 Jun;2(6):777-83 - PubMed
  227. ACS Nano. 2021 Mar 23;15(3):5545-5559 - PubMed
  228. Materials (Basel). 2020 Sep 08;13(18): - PubMed
  229. Nat Biotechnol. 2013 Aug;31(8):686-8 - PubMed
  230. Glycobiology. 1994 Aug;4(4):451-8 - PubMed
  231. J Funct Biomater. 2018 Feb 07;9(1): - PubMed
  232. Biofabrication. 2016 Dec 02;9(1):012001 - PubMed
  233. ACS Nano. 2019 Mar 26;13(3):3353-3362 - PubMed
  234. Chem Soc Rev. 2005 Mar;34(3):276-85 - PubMed
  235. Mater Sci Eng R Rep. 2017 Sep;119:1-35 - PubMed

Publication Types

Grant support