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Pinto C, Malik P, Desai R, et al. Post-Hemorrhagic Hydrocephalus and Outcomes Amongst Neonates With Intraventricular Hemorrhage: A Systematic Review and Pooled Analysis. Cureus. 2021;13(10):e18877doi: 10.7759/cureus.18877.
Pinto, C., Malik, P., Desai, R., Shelar, V., Bekina-Sreenivasan, D., Satnarine, T. A., Lavado, L. K., Singla, R., Chavda, D., Kaul, S., Datta, S., Shah, S., & Patel, U. K. (2021). Post-Hemorrhagic Hydrocephalus and Outcomes Amongst Neonates With Intraventricular Hemorrhage: A Systematic Review and Pooled Analysis. Cureus, 13(10), e18877. https://doi.org/10.7759/cureus.18877
Pinto, Candida, et al. "Post-Hemorrhagic Hydrocephalus and Outcomes Amongst Neonates With Intraventricular Hemorrhage: A Systematic Review and Pooled Analysis." Cureus vol. 13,10 (2021): e18877. doi: https://doi.org/10.7759/cureus.18877
Pinto C, Malik P, Desai R, Shelar V, Bekina-Sreenivasan D, Satnarine TA, Lavado LK, Singla R, Chavda D, Kaul S, Datta S, Shah S, Patel UK. Post-Hemorrhagic Hydrocephalus and Outcomes Amongst Neonates With Intraventricular Hemorrhage: A Systematic Review and Pooled Analysis. Cureus. 2021 Oct 18;13(10):e18877. doi: 10.7759/cureus.18877. eCollection 2021 Oct. PMID: 34804726; PMCID: PMC8599435.
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Cureus. 2021 Oct 18;13(10):e18877. doi: 10.7759/cureus.18877. eCollection 2021 Oct.

Post-Hemorrhagic Hydrocephalus and Outcomes Amongst Neonates With Intraventricular Hemorrhage: A Systematic Review and Pooled Analysis.

Cureus

Candida Pinto, Preeti Malik, Rutikbhai Desai, Vrushali Shelar, Daria Bekina-Sreenivasan, Travis A Satnarine, Liseth K Lavado, Ramit Singla, Devraj Chavda, Surabhi Kaul, Shae Datta, Shamik Shah, Urvish K Patel

Affiliations

  1. Public Health, Icahn School of Medicine at Mount Sinai, New York, USA.
  2. Pathology, Montefiore Medical Center, Wakefield Campus, Bronx, USA.
  3. Internal Medicine, University of North Carolina Cardiology at Nash, Rocky Mount, USA.
  4. Internal Medicine, Saratov State Medical University, Saratov, RUS.
  5. Pediatric Medicine, Tyumen State Medical University, Tyumen, RUS.
  6. Neonatal Intensive Care Unit, Port of Spain General Hospital, Port of Spain, TTO.
  7. Nursing, Rutgers School of Nursing, Newark, USA.
  8. Pediatric Neurology, Children's Hospital of Michigan, Detroit, USA.
  9. Pediatric Neurology, State University of New York Downstate Medical Center, Brooklyn, USA.
  10. Pediatric Neurology, Mercyone North Iowa, Mason City, USA.
  11. Neurology, NYU Langone Health, New York, USA.
  12. Neurology, Stormont Vail Health, Topeka, USA.
  13. Neurology and Public Health, Icahn School of Medicine at Mount Sinai, New York, USA.

PMID: 34804726 PMCID: PMC8599435 DOI: 10.7759/cureus.18877

Abstract

Introduction Intraventricular hemorrhage (IVH) is a common cause of morbidity and mortality in preterm neonates. IVH leads to complications such as posthemorrhagic hydrocephalus (PHH), which commonly occurs in neonates with a more severe degree of IVH. Hence, we aimed to evaluate the characteristics and outcomes of PHH in neonates with IVH. Methods We performed a systematic review of cases reported from January 1978 to December 2020 through the PubMed database, using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the keywords 'intraventricular hemorrhage,' 'cerebral intraventricular hemorrhage,' and 'newborn.' A total of 79 articles were considered for analysis, and data on neonatal and maternal characteristics and outcomes were collected. The analysis was performed by using the χ2 test, Wilcoxon rank-sum test, and multivariate logistic regression model. Results We analyzed a total of 101 IVH cases, 54.5% were male and 62.4% preterm. Thirteen point nine percent (13.9%) presented with grade I, 35.6% grade II, and grade III respectively, and 8% grade IV IVH. Among the 59 (58.4%) neonates with PHH, 33.6% had resolved PHH and 24.8% had unresolved. In adjusted regression analysis, we found that neonates with resolved PHH have lower odds of having neurodevelopmental delay (OR:0.15, 95%CI:0.03-0.74; p=0.02) and death (OR:0.9;95%CI:0.01-0.99; p=0.049) as compared to unresolved PHH. Conclusion Our study showed that neonates with resolved PHH have a statistically significant lower risk of neurodevelopmental delay (NDD) and mortality. Future studies should be planned to evaluate the role of treatment and its effect on outcomes in IVH neonates with PHH as a complication.

Copyright © 2021, Pinto et al.

Keywords: hydrocephalus; intraventricular hemorrhage; neonates; newborn; preterm

Conflict of interest statement

The authors have declared that no competing interests exist.

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