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Alekseeva L, Mironova N. Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression. Int J Mol Sci. 2021;22(22)doi: 10.3390/ijms222212246.
Alekseeva, L., & Mironova, N. (2021). Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression. International journal of molecular sciences, 22(22), . https://doi.org/10.3390/ijms222212246
Alekseeva, Ludmila, and Mironova, Nadezhda. "Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression." International journal of molecular sciences vol. 22,22 (2021). doi: https://doi.org/10.3390/ijms222212246
Alekseeva L, Mironova N. Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression. Int J Mol Sci. 2021 Nov 12;22(22). doi: 10.3390/ijms222212246. PMID: 34830126; PMCID: PMC8625144.
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Int J Mol Sci. 2021 Nov 12;22(22). doi: 10.3390/ijms222212246.

Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression.

International journal of molecular sciences

Ludmila Alekseeva, Nadezhda Mironova

Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrentiev Ave., 8, 630090 Novosibirsk, Russia.

PMID: 34830126 PMCID: PMC8625144 DOI: 10.3390/ijms222212246

Abstract

Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile. Moreover, tumor-derived cfDNA can act like oncoviruses, entering the cells of vulnerable organs, transforming them and forming metastatic nodes. Another source of cfDNA is immune cells, including neutrophils that generate neutrophil extracellular traps (NETs). Despite the potential eliminative effect of NETs on tumors, in some cases, their excessive generation provokes tumor growth as well as invasion. Considering both possible pathological contributions of cfDNA, as an agent of oncotransformation and the main component of NETs, the study of deoxyribonucleases (DNases) as anticancer and antimetastatic agents is important and promising. This review considers the pathological role of cfDNA in cancer development and the role of DNases as agents to prevent and/or prohibit tumor progression and the development of metastases.

Keywords: DNases; circulating cell-free DNA; neutrophil extracellular traps (NETs); tumor and metastasis development

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