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Gligorijevic N, Radomirovic M, Nedic O, et al. Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention. Int J Mol Sci. 2021;22(22)doi: 10.3390/ijms222212385.
Gligorijevic, N., Radomirovic, M., Nedic, O., Stojadinovic, M., Khulal, U., Stanic-Vucinic, D., & Cirkovic Velickovic, T. (2021). Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention. International journal of molecular sciences, 22(22), . https://doi.org/10.3390/ijms222212385
Gligorijevic, Nikola, et al. "Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention." International journal of molecular sciences vol. 22,22 (2021). doi: https://doi.org/10.3390/ijms222212385
Gligorijevic N, Radomirovic M, Nedic O, Stojadinovic M, Khulal U, Stanic-Vucinic D, Cirkovic Velickovic T. Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention. Int J Mol Sci. 2021 Nov 17;22(22). doi: 10.3390/ijms222212385. PMID: 34830267; PMCID: PMC8625847.
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Int J Mol Sci. 2021 Nov 17;22(22). doi: 10.3390/ijms222212385.

Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention.

International journal of molecular sciences

Nikola Gligorijevic, Mirjana Radomirovic, Olgica Nedic, Marija Stojadinovic, Urmila Khulal, Dragana Stanic-Vucinic, Tanja Cirkovic Velickovic

Affiliations

  1. Institute for the Application of Nuclear Energy, Department for Metabolism, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
  2. Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.
  3. Faculty of Bioscience Engineering, Ghent University, 9000 Ghent, Belgium.
  4. Global Campus, Ghent University, Yeonsu-gu, Incheon 21985, Korea.
  5. Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia.

PMID: 34830267 PMCID: PMC8625847 DOI: 10.3390/ijms222212385

Abstract

The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19.

Keywords: SARS-CoV-2; antiviral effects; antiviral targets; polyphenols

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