Display options
Cite
Krętowski R, Jabłońska-Trypuć A, Cechowska-Pasko M. The Preliminary Study on the Proapoptotic Effect of Reduced Graphene Oxide in Breast Cancer Cell Lines. Int J Mol Sci. 2021;22(22)doi: 10.3390/ijms222212593.
Krętowski, R., Jabłońska-Trypuć, A., & Cechowska-Pasko, M. (2021). The Preliminary Study on the Proapoptotic Effect of Reduced Graphene Oxide in Breast Cancer Cell Lines. International journal of molecular sciences, 22(22), . https://doi.org/10.3390/ijms222212593
Krętowski, Rafał, et al. "The Preliminary Study on the Proapoptotic Effect of Reduced Graphene Oxide in Breast Cancer Cell Lines." International journal of molecular sciences vol. 22,22 (2021). doi: https://doi.org/10.3390/ijms222212593
Krętowski R, Jabłońska-Trypuć A, Cechowska-Pasko M. The Preliminary Study on the Proapoptotic Effect of Reduced Graphene Oxide in Breast Cancer Cell Lines. Int J Mol Sci. 2021 Nov 22;22(22). doi: 10.3390/ijms222212593. PMID: 34830472; PMCID: PMC8620501.
Copy Download .nbib Format: NLM
Share it on

Int J Mol Sci. 2021 Nov 22;22(22). doi: 10.3390/ijms222212593.

The Preliminary Study on the Proapoptotic Effect of Reduced Graphene Oxide in Breast Cancer Cell Lines.

International journal of molecular sciences

Rafał Krętowski, Agata Jabłońska-Trypuć, Marzanna Cechowska-Pasko

Affiliations

  1. Department of Pharmaceutical Biochemistry, Medical University of Bialystok, 15-089 Bialystok, Poland.
  2. Division of Chemistry, Biology and Biotechnology, Bialystok University of Technology, 15-351 Bialystok, Poland.

PMID: 34830472 PMCID: PMC8620501 DOI: 10.3390/ijms222212593

Abstract

Breast cancer is the most common cancer diagnosed in women, however traditional therapies have several side effects. This has led to an urgent need to explore novel drug approaches to treatment strategies such as graphene-based nanomaterials such as reduced graphene oxide (rGO). It was noticed as a potential drug due to its target selectivity, easy functionalisation, chemisensitisation, and high drug-loading capacity. rGO is widely used in many fields, including biological and biomedical, due to its unique physicochemical properties. However, the possible mechanisms of rGO toxicity remain unclear. In this paper, we present findings on the cytotoxic and antiproliferative effects of rGO and its ability to induce oxidative stress and apoptosis of breast cancer cell lines. We indicate that rGO induced time- and dose-dependent cytotoxicity in MDA-MB-231 and ZR-75-1 cell lines, but not in T-47D, MCF-7, Hs 578T cell lines. In rGO-treated MDA-MB-231 and ZR-75-1 cell lines, we noticed increased induction of apoptosis and necrosis. In addition, rGO has been found to cause oxidative stress, reduce proliferation, and induce structural changes in breast cancer cells. Taken together, these studies provide new insight into the mechanism of oxidative stress and apoptosis in breast cancer cells.

Keywords: apoptosis; breast cancer; oxidative stress; proliferation; rGO

References

  1. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Nov-Dec;7(6):779-96 - PubMed
  2. J Mater Chem B. 2016 May 21;4(19):3169-3190 - PubMed
  3. Part Fibre Toxicol. 2013 Jul 12;10:27 - PubMed
  4. Int J Mol Sci. 2018 Mar 01;19(3): - PubMed
  5. Mol Cell Biochem. 2016 Jun;417(1-2):35-47 - PubMed
  6. J Transl Med. 2020 May 14;18(1):200 - PubMed
  7. J Cancer. 2017 Sep 12;8(16):3131-3141 - PubMed
  8. J Appl Toxicol. 2018 Apr;38(4):504-513 - PubMed
  9. Oxid Med Cell Longev. 2016;2016:5851035 - PubMed
  10. J Nanobiotechnology. 2021 Jul 15;19(1):211 - PubMed
  11. Cancers (Basel). 2021 Aug 18;13(16): - PubMed
  12. Cells. 2021 Mar 19;10(3): - PubMed
  13. Mol Endocrinol. 1994 Nov;8(11):1474-83 - PubMed
  14. Drug Dev Ind Pharm. 2020 Mar;46(3):462-470 - PubMed
  15. Nano Converg. 2020 Mar 17;7(1):10 - PubMed
  16. Toxicol Lett. 2007 Jan 10;168(1):58-74 - PubMed
  17. Front Plant Sci. 2019 Jun 25;10:800 - PubMed
  18. ACS Nano. 2014 Mar 25;8(3):2100-10 - PubMed
  19. Int J Nanomedicine. 2015 Oct 05;10:6257-76 - PubMed
  20. Adv Mater. 2020 Feb;32(5):e1901979 - PubMed
  21. Lipids. 2016 Sep;51(9):1021-35 - PubMed
  22. Int J Mol Sci. 2019 Feb 02;20(3): - PubMed
  23. Int J Nanomedicine. 2015 Feb 25;10:1585-96 - PubMed
  24. Part Fibre Toxicol. 2016 Oct 31;13(1):57 - PubMed
  25. Oxid Med Cell Longev. 2019 Oct 13;2019:5080843 - PubMed
  26. Mater Sci Eng C Mater Biol Appl. 2015 Oct;55:482-9 - PubMed
  27. Nat Rev Mol Cell Biol. 2019 Mar;20(3):175-193 - PubMed
  28. Front Cell Dev Biol. 2021 Mar 18;9:616888 - PubMed
  29. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed

Publication Types