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Baillieul S, Bailly S, Detante O, et al. Sleep-disordered breathing and ventilatory chemosensitivity in first ischaemic stroke patients: a prospective cohort study. Thorax. 2021;doi: 10.1136/thoraxjnl-2021-218003.
Baillieul, S., Bailly, S., Detante, O., Alexandre, S., Destors, M., Clin, R., Dole, M., Pépin, J. L., & Tamisier, R. (2021). Sleep-disordered breathing and ventilatory chemosensitivity in first ischaemic stroke patients: a prospective cohort study. Thorax, . https://doi.org/10.1136/thoraxjnl-2021-218003
Baillieul, Sébastien, et al. "Sleep-disordered breathing and ventilatory chemosensitivity in first ischaemic stroke patients: a prospective cohort study." Thorax vol. (2021). doi: https://doi.org/10.1136/thoraxjnl-2021-218003
Baillieul S, Bailly S, Detante O, Alexandre S, Destors M, Clin R, Dole M, Pépin JL, Tamisier R. Sleep-disordered breathing and ventilatory chemosensitivity in first ischaemic stroke patients: a prospective cohort study. Thorax. 2021 Nov 12; doi: 10.1136/thoraxjnl-2021-218003. Epub 2021 Nov 12. PMID: 34772798.
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Thorax. 2021 Nov 12; doi: 10.1136/thoraxjnl-2021-218003. Epub 2021 Nov 12.

Sleep-disordered breathing and ventilatory chemosensitivity in first ischaemic stroke patients: a prospective cohort study.

Thorax

Sébastien Baillieul, Sébastien Bailly, Olivier Detante, Sarah Alexandre, Marie Destors, Rita Clin, Marjorie Dole, Jean-Louis Pépin, Renaud Tamisier

Affiliations

  1. Univ. Grenoble Alpes, Inserm, U1300, CHU Grenoble Alpes, Service Universitaire de Pneumologie Physiologie, 38000 Grenoble, France [email protected].
  2. Univ. Grenoble Alpes, Inserm, U1300, CHU Grenoble Alpes, Service Universitaire de Pneumologie Physiologie, 38000 Grenoble, France.
  3. Stroke Unit, Neurology Department, Grenoble Alpes University Hospital, Grenoble, France.
  4. Grenoble Institute of Neurosciences, Inserm U1216, Université Grenoble Alpes, Grenoble, France.

PMID: 34772798 DOI: 10.1136/thoraxjnl-2021-218003

Abstract

RATIONALE: Sleep-disordered breathing (SDB) is highly prevalent after stroke. The clinical and ventilatory chemosensitivity characteristics of SDB, namely obstructive, central and coexisting obstructive and central sleep apnoea (coexisting sleep apnoea) following stroke are poorly described.

OBJECTIVE: To determine the respective clinical and ventilatory chemosensitivity characteristics of SDB at least 3 months after a first ischaemic stroke.

METHODS: Cross-sectional analysis of a prospective, monocentric cohort conducted in a university hospital. 380 consecutive stroke or transient ischaemic attack patients were screened between December 2016 and December 2019.

MEASUREMENTS AND MAIN RESULTS: Full-night polysomnography, and hypercapnic ventilatory response were performed at a median (Q1; Q3) time from stroke onset of 134.5 (97.0; 227.3) days. 185 first-time stroke patients were included in the analysis. 94 (50.8%) patients presented no or mild SDB (Apnoea-Hypopnoea Index <15 events/hour of sleep) and 91 (49.2%) moderate to severe SDB, of which 52 (57.1%) presented obstructive sleep apnoea and 39 (42.9%) coexisting or central sleep apnoea. Obstructive sleep apnoea patients significantly differed regarding their clinical presentation from patients with no or mild SDB, whereas there was no difference with coexisting and central sleep apnoea patients. The latter presented a higher frequency of cerebellar lesions along with a heightened hypercapnic ventilatory response compared with no or mild SDB patients.

CONCLUSION: SDB in first-time stroke patients differ in their presentation by their respective clinical traits and ventilatory chemosensitivity characteristics. The heightened hypercapnic ventilatory response in coexisting and central sleep apnoea stroke patients may orientate them to specific ventilatory support.

© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: respiratory measurement; sleep apnoea

Conflict of interest statement

Competing interests: None declared.

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