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Kulczyńska-Przybik A, Dulewicz M, Słowik A, et al. The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases. J Clin Med. 2021;10(22)doi: 10.3390/jcm10225281.
Kulczyńska-Przybik, A., Dulewicz, M., Słowik, A., Borawska, R., Kułakowska, A., Kochanowicz, J., & Mroczko, B. (2021). The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases. Journal of clinical medicine, 10(22), . https://doi.org/10.3390/jcm10225281
Kulczyńska-Przybik, Agnieszka, et al. "The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases." Journal of clinical medicine vol. 10,22 (2021). doi: https://doi.org/10.3390/jcm10225281
Kulczyńska-Przybik A, Dulewicz M, Słowik A, Borawska R, Kułakowska A, Kochanowicz J, Mroczko B. The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases. J Clin Med. 2021 Nov 13;10(22). doi: 10.3390/jcm10225281. PMID: 34830564; PMCID: PMC8622503.
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J Clin Med. 2021 Nov 13;10(22). doi: 10.3390/jcm10225281.

The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases.

Journal of clinical medicine

Agnieszka Kulczyńska-Przybik, Maciej Dulewicz, Agnieszka Słowik, Renata Borawska, Alina Kułakowska, Jan Kochanowicz, Barbara Mroczko

Affiliations

  1. Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
  2. Department of Neurology, Jagiellonian University, 30-688 Kraków, Poland.
  3. Department of Neurology, Medical University of Bialystok, 15-269 Bialystok, Poland.
  4. Department of Biochemical Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.

PMID: 34830564 PMCID: PMC8622503 DOI: 10.3390/jcm10225281

Abstract

Neurodegenerative diseases (NDs) belong to the top global causes of mortality. Diagnostic approaches to improve early diagnosis and differentiation of these diseases are constantly being sought. Therefore, we aimed to assess the cerebrospinal fluid (CSF) concentrations of Reticulon 4 (RTN4) in patients with neurodegenerative diseases and evaluate the potential clinical usefulness of this protein. RTNs are transmembrane proteins mediating neuroanatomical plasticity and functional recovery after central nervous system injury or diseases. According to our best knowledge, this is the first investigation providing the data concerning the dynamic of CSF RTN4 protein levels in patients with different NDs.

METHODS: Overall, 77 newly diagnosed patients with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), as well as 21 controls, were enrolled in the study. The CSF concentrations of tested proteins were assessed using immunological assays.

RESULTS: We revealed significantly higher CSF RTN4A levels in patients with AD, PD, and MS in comparison to the controls. Moreover, the comparative analysis of RTN4 concentration between different neurodegenerative diseases revealed the highest concentration of RTN4A in AD patients and a statistically significant difference between AD vs. PD, and AD vs. MS groups. The increased CSF level of the protein correlated with Tau, and pTau181 proteins in AD as well as in PD patients.

CONCLUSIONS: Our study presents a previously not identified clinical utility of RTN4 in the differential diagnosis of neurodegenerative diseases.

Keywords: Alzheimer’s disease; Parkinson’s disease; RTN-4A; biomarkers; multiple sclerosis; neurodegenerative diseases; reticulons

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